Role of circRNA in E3 Modification under Human Disease
Circular RNA (circRNA) is often regarded as a special kind of non-coding RNA, involved in the regulation mechanism of various diseases, such as tumors, neurological diseases, and inflammation. In a broad spectrum of biological processes, the modification of the 76-amino acid ubiquitin protein genera...
| Published in: | Biomolecules |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/12/9/1320 |
| _version_ | 1850101662438391808 |
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| author | Zishuo Chen Minkai Song Ting Wang Jiawen Gao Fei Lin Hui Dai Chao Zhang |
| author_facet | Zishuo Chen Minkai Song Ting Wang Jiawen Gao Fei Lin Hui Dai Chao Zhang |
| author_sort | Zishuo Chen |
| collection | DOAJ |
| container_title | Biomolecules |
| description | Circular RNA (circRNA) is often regarded as a special kind of non-coding RNA, involved in the regulation mechanism of various diseases, such as tumors, neurological diseases, and inflammation. In a broad spectrum of biological processes, the modification of the 76-amino acid ubiquitin protein generates a large number of signals with different cellular results. Each modification may change the result of signal transduction and participate in the occurrence and development of diseases. Studies have found that circRNA-mediated ubiquitination plays an important role in a variety of diseases. This review first introduces the characteristics of circRNA and ubiquitination and summarizes the mechanism of circRNA in the regulation of ubiquitination in various diseases. It is hoped that the emergence of circRNA-mediated ubiquitination can broaden the diagnosis and prognosis of the disease. |
| format | Article |
| id | doaj-art-6a331c9f38d6447db6cb07e7eea6a5a3 |
| institution | Directory of Open Access Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-6a331c9f38d6447db6cb07e7eea6a5a32025-08-20T00:04:22ZengMDPI AGBiomolecules2218-273X2022-09-01129132010.3390/biom12091320Role of circRNA in E3 Modification under Human DiseaseZishuo Chen0Minkai Song1Ting Wang2Jiawen Gao3Fei Lin4Hui Dai5Chao Zhang6Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, ChinaDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaGuangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, ChinaDivision of Spinal Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, ChinaGuangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, ChinaHospital Office, Ganzhou People’s Hospital, Ganzhou 341000, ChinaGuangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University, Guangzhou 510515, ChinaCircular RNA (circRNA) is often regarded as a special kind of non-coding RNA, involved in the regulation mechanism of various diseases, such as tumors, neurological diseases, and inflammation. In a broad spectrum of biological processes, the modification of the 76-amino acid ubiquitin protein generates a large number of signals with different cellular results. Each modification may change the result of signal transduction and participate in the occurrence and development of diseases. Studies have found that circRNA-mediated ubiquitination plays an important role in a variety of diseases. This review first introduces the characteristics of circRNA and ubiquitination and summarizes the mechanism of circRNA in the regulation of ubiquitination in various diseases. It is hoped that the emergence of circRNA-mediated ubiquitination can broaden the diagnosis and prognosis of the disease.https://www.mdpi.com/2218-273X/12/9/1320circRNAubiquitination machinerycell signal transductionubiquitin systemmiRNA |
| spellingShingle | Zishuo Chen Minkai Song Ting Wang Jiawen Gao Fei Lin Hui Dai Chao Zhang Role of circRNA in E3 Modification under Human Disease circRNA ubiquitination machinery cell signal transduction ubiquitin system miRNA |
| title | Role of circRNA in E3 Modification under Human Disease |
| title_full | Role of circRNA in E3 Modification under Human Disease |
| title_fullStr | Role of circRNA in E3 Modification under Human Disease |
| title_full_unstemmed | Role of circRNA in E3 Modification under Human Disease |
| title_short | Role of circRNA in E3 Modification under Human Disease |
| title_sort | role of circrna in e3 modification under human disease |
| topic | circRNA ubiquitination machinery cell signal transduction ubiquitin system miRNA |
| url | https://www.mdpi.com/2218-273X/12/9/1320 |
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