Targeted therapies in bladder cancer: signaling pathways, applications, and challenges
Abstract Bladder cancer (BC) is one of the most prevalent malignancies in men. Understanding molecular characteristics via studying signaling pathways has made tremendous breakthroughs in BC therapies. Thus, targeted therapies including immune checkpoint inhibitors (ICIs), antibody–drug conjugates (...
| Published in: | MedComm |
|---|---|
| Main Authors: | Mei Peng, Xuetong Chu, Yan Peng, Duo Li, Zhirong Zhang, Weifan Wang, Xiaochen Zhou, Di Xiao, Xiaoping Yang |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-12-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.455 |
Similar Items
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer
by: Macus Hao-Ran Bao, et al.
Published: (2021-07-01)
by: Macus Hao-Ran Bao, et al.
Published: (2021-07-01)
Editorial: Hepatocellular carcinoma: novel treatment strategies, volume III
by: Fan Feng, et al.
Published: (2025-09-01)
by: Fan Feng, et al.
Published: (2025-09-01)
Recent Advancements of Monotherapy, Combination, and Sequential Treatment of EGFR/ALK-TKIs and ICIs in Non–Small Cell Lung Cancer
by: Dehua Liao, et al.
Published: (2022-06-01)
by: Dehua Liao, et al.
Published: (2022-06-01)
HBV reactivation and its effect on survival in HBV-related hepatocarcinoma patients undergoing transarterial chemoembolization combined with tyrosine kinase inhibitors plus immune checkpoint inhibitors
by: Jiaming Shen, et al.
Published: (2023-05-01)
by: Jiaming Shen, et al.
Published: (2023-05-01)
Combination therapy of TKIs and ICIs for the treatment of anaplastic thyroid carcinoma
by: Xi Zhang, et al.
Published: (2025-05-01)
by: Xi Zhang, et al.
Published: (2025-05-01)
Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids
by: Amira Abugomaa, et al.
Published: (2023-04-01)
by: Amira Abugomaa, et al.
Published: (2023-04-01)
Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer
by: Zhen Zeng, et al.
Published: (2023-10-01)
by: Zhen Zeng, et al.
Published: (2023-10-01)
ADCs and TCE in SCLC Therapy: The Beginning of a New Era?
by: Paola Muscolino, et al.
Published: (2025-04-01)
by: Paola Muscolino, et al.
Published: (2025-04-01)
Immunotherapy and radiotherapy for older patients with invasive bladder cancer unfit for surgery or chemotherapy: practical proposal by the international geriatric radiotherapy group
by: Nam Phong Nguyen, et al.
Published: (2024-07-01)
by: Nam Phong Nguyen, et al.
Published: (2024-07-01)
Transcriptomic insights into UTUC: role of inflammatory fibrosis and potential for personalized treatment
by: Keqiang Li, et al.
Published: (2024-01-01)
by: Keqiang Li, et al.
Published: (2024-01-01)
The cuproptosis-associated 11 gene signature as a predictor for outcomes and response to Bacillus Calmette-Guerin and immune checkpoint inhibitor therapies in bladder carcinoma
by: Huiyang Yuan, et al.
Published: (2023-05-01)
by: Huiyang Yuan, et al.
Published: (2023-05-01)
The Antiasthma Medication Ciclesonide Suppresses Breast Cancer Stem Cells through Inhibition of the Glucocorticoid Receptor Signaling-Dependent YAP Pathway
by: Su-Lim Kim, et al.
Published: (2020-12-01)
by: Su-Lim Kim, et al.
Published: (2020-12-01)
Cholesterol and Mevalonate: Two Metabolites Involved in Breast Cancer Progression and Drug Resistance through the ERRα Pathway
by: Matteo Brindisi, et al.
Published: (2020-07-01)
by: Matteo Brindisi, et al.
Published: (2020-07-01)
Microvascular rarefaction caused by the NOTCH signaling pathway is a key cause of TKI-apatinib-induced hypertension and cardiac damage
by: WenJuan Wang, et al.
Published: (2024-02-01)
by: WenJuan Wang, et al.
Published: (2024-02-01)
Impact of HER2 Expression on the Prognosis of Muscle-Invasive Bladder Cancer Patients Treated with Bladder-Preservation Comprehensive Therapy
by: Yatong Chen, et al.
Published: (2025-01-01)
by: Yatong Chen, et al.
Published: (2025-01-01)
Stearoyl CoA desaturase inhibition can effectively induce apoptosis in bladder cancer stem cells
by: Yuchen Li, et al.
Published: (2024-10-01)
by: Yuchen Li, et al.
Published: (2024-10-01)
Combination immunotherapy in hepatocellular carcinoma: synergies among immune checkpoints, TKIs, and chemotherapy
by: Suoyi Dai, et al.
Published: (2025-09-01)
by: Suoyi Dai, et al.
Published: (2025-09-01)
Antibody-drug conjugates in urinary tumors: clinical application, challenge, and perspectives
by: Keqiang Li, et al.
Published: (2023-12-01)
by: Keqiang Li, et al.
Published: (2023-12-01)
Update on immune‐based therapy strategies targeting cancer stem cells
by: Amirhossein Izadpanah, et al.
Published: (2023-09-01)
by: Amirhossein Izadpanah, et al.
Published: (2023-09-01)
Identification of a novel combination treatment strategy in clear cell renal cell carcinoma stem cells with shikonin and ipilimumab
by: Chen Lyu, et al.
Published: (2023-08-01)
by: Chen Lyu, et al.
Published: (2023-08-01)
Immune-Checkpoint Inhibitors in Advanced Bladder Cancer: Seize the Day
by: Brigida Anna Maiorano, et al.
Published: (2022-02-01)
by: Brigida Anna Maiorano, et al.
Published: (2022-02-01)
EGFR-TKIs resistance via EGFR-independent signaling pathways
by: Qian Liu, et al.
Published: (2018-02-01)
by: Qian Liu, et al.
Published: (2018-02-01)
Profiling and targeting cancer stem cell signaling pathways for cancer therapeutics
by: Mia C. Borlongan, et al.
Published: (2023-05-01)
by: Mia C. Borlongan, et al.
Published: (2023-05-01)
Nephrotoxicity of targeted therapy used to treat lung cancer
by: Qiuling Li, et al.
Published: (2024-07-01)
by: Qiuling Li, et al.
Published: (2024-07-01)
Significance of CD133 Expression in Invasive Ductal Carcinoma of the Breast
by: Nagwa Abd El-Sadek Ahmed, et al.
Published: (2022-02-01)
by: Nagwa Abd El-Sadek Ahmed, et al.
Published: (2022-02-01)
Evaluation of EGFR-TKIs and ICIs treatment stratification in non-small cell lung cancer using an encrypted multidimensional radiomics approach
by: Xingping Zhang, et al.
Published: (2025-01-01)
by: Xingping Zhang, et al.
Published: (2025-01-01)
IFIT3 accelerates the progression of head and neck squamous cell carcinoma by targeting PD-L1 to activate PI3K/AKT signaling pathway
by: Peng Liu, et al.
Published: (2024-01-01)
by: Peng Liu, et al.
Published: (2024-01-01)
Development a hyaluronic acid ion-pairing liposomal nanoparticle for enhancing anti-glioma efficacy by modulating glioma microenvironment
by: Liuqing Yang, et al.
Published: (2018-01-01)
by: Liuqing Yang, et al.
Published: (2018-01-01)
Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma
by: Yanlong Zhang, et al.
Published: (2023-02-01)
by: Yanlong Zhang, et al.
Published: (2023-02-01)
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma: Current Progresses and Challenges
by: Hao-Tian Liu, et al.
Published: (2021-10-01)
by: Hao-Tian Liu, et al.
Published: (2021-10-01)
Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway
by: Sunisa Thongsom, et al.
Published: (2023-06-01)
by: Sunisa Thongsom, et al.
Published: (2023-06-01)
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
by: Luyao Wang, et al.
Published: (2025-11-01)
by: Luyao Wang, et al.
Published: (2025-11-01)
Deferiprone (DFP) Targets Cancer Stem Cell (CSC) Propagation by Inhibiting Mitochondrial Metabolism and Inducing ROS Production
by: Marco Fiorillo, et al.
Published: (2020-06-01)
by: Marco Fiorillo, et al.
Published: (2020-06-01)
The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity
by: Hayley R. Walsh, et al.
Published: (2019-08-01)
by: Hayley R. Walsh, et al.
Published: (2019-08-01)
RC48-ADC combined with tislelizumab as neoadjuvant treatment in patients with HER2-positive locally advanced muscle-invasive urothelial bladder cancer: a multi-center phase Ib/II study (HOPE-03)
by: Feng Wen, et al.
Published: (2024-01-01)
by: Feng Wen, et al.
Published: (2024-01-01)
Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatment
by: Mahdie Rahban, et al.
Published: (2024-01-01)
by: Mahdie Rahban, et al.
Published: (2024-01-01)
Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22/STAT3/AKT pathway
by: Jiali Wang, et al.
Published: (2024-12-01)
by: Jiali Wang, et al.
Published: (2024-12-01)
Antibody-drug conjugates as game changers in bladder cancer: current progress and future directions
by: Fei Zhang, et al.
Published: (2025-05-01)
by: Fei Zhang, et al.
Published: (2025-05-01)
Cancer stem cell biomarkers: critical roles, challenges, clinical applications and perspectives in cancer therapy
by: Elham Bahrami Salehloo, et al.
Published: (2022-05-01)
by: Elham Bahrami Salehloo, et al.
Published: (2022-05-01)
Detection of cancer stem cell in invasive ductal carcinoma of breast using CD44marker
by: Teeba Khalid Hadi, et al.
Published: (2014-09-01)
by: Teeba Khalid Hadi, et al.
Published: (2014-09-01)
Similar Items
-
Hypoxia, Metabolic Reprogramming, and Drug Resistance in Liver Cancer
by: Macus Hao-Ran Bao, et al.
Published: (2021-07-01) -
Editorial: Hepatocellular carcinoma: novel treatment strategies, volume III
by: Fan Feng, et al.
Published: (2025-09-01) -
Recent Advancements of Monotherapy, Combination, and Sequential Treatment of EGFR/ALK-TKIs and ICIs in Non–Small Cell Lung Cancer
by: Dehua Liao, et al.
Published: (2022-06-01) -
HBV reactivation and its effect on survival in HBV-related hepatocarcinoma patients undergoing transarterial chemoembolization combined with tyrosine kinase inhibitors plus immune checkpoint inhibitors
by: Jiaming Shen, et al.
Published: (2023-05-01) -
Combination therapy of TKIs and ICIs for the treatment of anaplastic thyroid carcinoma
by: Xi Zhang, et al.
Published: (2025-05-01)
