Pharmacokinetics of Paroxetine Tablets in healthy Arabic Subjects

A single oral dose of paroxetine 20 mg tablets (Seroxat®, GlaxoSmithKline, England) were administered to thirty six healthy male adult fasting subjects to study the pharmacokinetics of the drug in Arabic population. Twenty blood samples were obtained from each subject up to 96 hours...

Full description

Bibliographic Details
Published in:	Al-Mustansiriyah Journal of Pharmaceutical Sciences
Main Author:	Jaafar Jaber Ibraheem Al-Tamimi
Format:	Article
Language:	English
Published:	College of Pharmacy / Mustansiriyah University 2016-06-01
Subjects:	Paroxetine, Pharmacokinetics, Healthy Arabic subjects.
Online Access:	https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/94

Similar Items

Pharmacokinetics and Dose Proportionality of Betahistine in Healthy Individuals
by: Duaa J. Al-Tamimi, et al.
Published: (2020-03-01)

Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects
by: Dong R, et al.
Published: (2024-12-01)

Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects
by: Yingying Hu, et al.
Published: (2023-08-01)

Paroxetine in the Treatment of Post Traumatic Stress Disorder: Our Experiences
by: Abdulah Kučukalić, et al.
Published: (2008-02-01)

Drug-drug interaction of paroxetine on olanzapine and initial dosage optimization in patients with major depressive disorder based on population pharmacokinetics
by: Cun Zhang, et al.
Published: (2025-05-01)

Observational multicenter study of efficacy of paroxetine film-coated tablet in the treatment of anxiety disorder
by: Alma Džubur Kulenović, et al.
Published: (2018-08-01)

Paroxetine-induced galactorrhea
by: S. Petrykiv, et al.
Published: (2022-06-01)

Population Pharmacokinetic Analysis of Cefaclor in Healthy Korean Subjects
by: Seung-Hyun Jeong, et al.
Published: (2021-05-01)

Population Pharmacokinetic Analysis of Tiropramide in Healthy Korean Subjects
by: Seung-Hyun Jeong, et al.
Published: (2020-04-01)

Anti-proliferative effects of paroxetine alone or in combination with sorafenib in HepG2 cells
by: Yaprak Donmez Cakil, et al.
Published: (2023-01-01)

Paroxetine prevented the down-regulation of astrocytic L-Glu transporters in neuroinflammation
by: Koki Fujimori, et al.
Published: (2015-01-01)

Pharmacokinetics, pharmacodynamics, and safety of prandial oral insulin (N11005) in healthy subjects
by: Qi Pan, et al.
Published: (2023-07-01)

First Episode Mania Probably Associated with Discontinuation of Paroxetine Treatment
by: Birmay Cam
Published: (2015-03-01)

Comparison of Pharmacokinetics of Aprepitant in Healthy Chinese and Caucasian Subjects
by: Yang MJ, et al.
Published: (2020-03-01)

A phase I, randomized, double-blind, parallel, single-dose pharmacokinetic study to evaluate the biosimilarity of KM118 (proposed pertuzumab biosimilar) with reference pertuzumab (Perjeta®) in healthy male subjects
by: Yan Li, et al.
Published: (2025-12-01)

Paroxetine induced larva zebrafish cardiotoxicity through inflammation response
by: Yuanhui Zhu, et al.
Published: (2023-07-01)

Pharmacokinetics and bioequivalence of two formulations of mifepristone tablets in healthy Chinese subjects under fasting conditions: a single-center, open, randomized, single-dose, double-period, two-sequence, crossover trial
by: Yufeng Yan, et al.
Published: (2024-10-01)

Pharmacokinetics and bioequivalence study of esomeprazole magnesium enteric-coated tablets 20 mg in healthy Chinese subjects under fasting and fed conditions
by: Ying Ding, et al.
Published: (2023-04-01)

Psychopharmacotherapy of panic disorder: 8-week randomized trial with clonazepam and paroxetine
by: A.E. Nardi, et al.
Published: (2011-04-01)

Repurposing of paroxetine and fluoxetine for their antibacterial effects against clinical Pseudomonas aeruginosa isolates in Egypt
by: Kholoud Baraka, et al.
Published: (2025-02-01)

Paroxetine overdose during pregnancy
by: Selin Acar, et al.
Published: (2021-07-01)

Corrigendum: Pharmacokinetics and bioequivalence study of esomeprazole magnesium enteric-coated tablets 20 mg in healthy Chinese subjects under fasting and fed conditions
by: Ying Ding, et al.
Published: (2023-06-01)

Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects
by: Jie Cheng, et al.
Published: (2025-02-01)

Paroxetine suppresses reactive microglia-mediated but not lipopolysaccharide-induced inflammatory responses in primary astrocytes
by: Xiong Zhang, et al.
Published: (2020-02-01)

Selective serotonin reuptake inhibitors-paroxetine induced galactorrhea in a case of somatoform disorder
by: Ajay Halder, et al.
Published: (2015-01-01)

Pharmacokinetics and Safety of Rifamycin SV after Single and Multiple Doses of MMX<sup>®</sup> Modified Release Tablets in Healthy Male and Female Volunteers
by: Andrea Francesco Daniele Di Stefano, et al.
Published: (2021-02-01)

Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone
by: Simeon Rüdesheim, et al.
Published: (2022-08-01)

Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals
by: Fatemeh Ganjalishahi, et al.
Published: (2021-08-01)

Paroxetine Attenuates Chondrocyte Pyroptosis and Inhibits Osteoclast Formation by Inhibiting NF-κB Pathway Activation to Delay Osteoarthritis Progression
by: Zheng X, et al.
Published: (2023-08-01)

Is paroxetine causing me nightmares?
by: Akansha Bhardwaj, et al.
Published: (2024-01-01)

A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
by: Qian Chen, et al.
Published: (2023-12-01)

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations
by: Yu Wang, et al.
Published: (2022-07-01)

Apigenin Attenuates Paroxetine-Induced Ovarian Alterations in Female Rats
by: Nazife Ulker Ertugrul, et al.
Published: (2026-05-01)

Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study
by: Yun Kuang, et al.
Published: (2022-05-01)

Adding metoclopramide to paroxetine induced extrapyramidal symptoms and hyperprolactinemia in a depressed woman: a case report
by: Igata R, et al.
Published: (2016-09-01)

Comparative Sleep Architecture Profiles of Antidepressants in Mice: Pharmacological Characterization of Paroxetine, Sertraline, Duloxetine, Mirtazapine and Vortioxetine
by: Junya Maruoka, et al.
Published: (2026-06-01)

Effects of paroxetine combined with sulpiride on sleep status and quality of life in patients with depressive episodes
by: Di Zhao, et al.
Published: (2025-09-01)

Synergistic effect of Chaihu-Shugan-San combined with paroxetine tablets in the treatment of acquired premature ejaculation: study protocol for a randomized controlled proof-of-concept trial
by: Shengqiang Qian, et al.
Published: (2025-10-01)

Comparing the Effectiveness of Paroxetine, Attention Modification Program and Combination of both on Improving Social Anxiety Symptoms
by: Hosein Khedmatgozar, et al.
Published: (2012-08-01)

Meta-analysis of Therapeutic Effect in Depression Treatment of Repetitive Transcranial Magnetic Stimulation Combined Paroxetine
by: Xinyi GUO, et al.
Published: (2019-04-01)