PREPARATION AND CHARACTERIZATION OF ATORVASTATIN-LOADED POLYVINYLPIRROLIDONE-BASED ELECTROSPUN MICROFIBROUS MATS
The aim of this experimental work was the enhancement of water solubility of the lipid lowering drug, atorvastatin, by embedding it in polymer based micro-sized fibers, prepared by electrospinning. Characterization of the fibrous mats included morphological investigations, determination of drug cont...
| Published in: | Studia Universitatis Babes-Bolyai Chemia |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Babes-Bolyai University
2021-06-01
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| Subjects: | |
| Online Access: | https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/7880 |
| Summary: | The aim of this experimental work was the enhancement of water solubility of the lipid lowering drug, atorvastatin, by embedding it in polymer based micro-sized fibers, prepared by electrospinning. Characterization of the fibrous mats included morphological investigations, determination of drug content, disintegration time, small volume dissolution- and DSC studies. The electrospinning process was continuous without droplet formation. The obtained fibers were homogenous, continuous filaments with smooth surfaces. Average fiber diameters were slightly above 1 µm, while disintegration of fiber mats upon contact with water was almost instantaneous (three to ten seconds). Dissolution of the lipid lowering drug was almost complete, when using a solution feed rate of 1 mL/h. |
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| ISSN: | 1224-7154 2065-9520 |