PREPARATION AND CHARACTERIZATION OF ATORVASTATIN-LOADED POLYVINYLPIRROLIDONE-BASED ELECTROSPUN MICROFIBROUS MATS

• Published in: Studia Universitatis Babes-Bolyai Chemia
• Main Authors: Emőke RÉDAI, Izabella RÁDULY, Zoltán-István SZABÓ, Adriana CIURBA, Nicoleta TODORAN, Paula ANTONOAEA, Robert-Alexandru VLAD, Orsolya PÉTERFI, Emese SIPOS
• Format: Article
• Language: English
• Published: Babes-Bolyai University 2021-06-01
• Subjects: atorvastatin, electrospinning, PVP, microfibrous mats.
• Online Access: https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/7880

The aim of this experimental work was the enhancement of water solubility of the lipid lowering drug, atorvastatin, by embedding it in polymer based micro-sized fibers, prepared by electrospinning. Characterization of the fibrous mats included morphological investigations, determination of drug content, disintegration time, small volume dissolution- and DSC studies. The electrospinning process was continuous without droplet formation. The obtained fibers were homogenous, continuous filaments with smooth surfaces. Average fiber diameters were slightly above 1 µm, while disintegration of fiber mats upon contact with water was almost instantaneous (three to ten seconds). Dissolution of the lipid lowering drug was almost complete, when using a solution feed rate of 1 mL/h.