CLDN5: From structure and regulation to roles in tumors and other diseases beyond CNS disorders
Claudin-5 (CLDN5) is an essential component of tight junctions (TJs) and is critical for the integrity of the blood-brain barrier (BBB), ensuring homeostasis and protection from damage to the central nervous system (CNS). Currently, many researchers have summarized the role and mechanisms of CLDN5 i...
| Published in: | Pharmacological Research |
|---|---|
| Main Authors: | Yao Ling, Xinxin Kang, Ying Yi, Shenao Feng, Guanshen Ma, Huinan Qu |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-02-01
|
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661824000197 |
Similar Items
Hsa-miR-31-3p targets CLDN8 to compromise skin barrier integrity in psoriasis
by: Yunhua Tu, et al.
Published: (2025-06-01)
by: Yunhua Tu, et al.
Published: (2025-06-01)
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family
by: Peipei Gao, et al.
Published: (2021-06-01)
by: Peipei Gao, et al.
Published: (2021-06-01)
Tight junctional protein family, Claudins in cancer and cancer metastasis
by: Wenxiao Ji, et al.
Published: (2025-07-01)
by: Wenxiao Ji, et al.
Published: (2025-07-01)
The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis
by: Adrian Georg Simon, et al.
Published: (2023-08-01)
by: Adrian Georg Simon, et al.
Published: (2023-08-01)
CLDN6 promotes chemoresistance through GSTP1 in human breast cancer
by: Minlan Yang, et al.
Published: (2017-11-01)
by: Minlan Yang, et al.
Published: (2017-11-01)
CLDN6 inhibits breast cancer growth and metastasis through SREBP1-mediated RAS palmitoylation
by: Qiu Jin, et al.
Published: (2024-08-01)
by: Qiu Jin, et al.
Published: (2024-08-01)
Novel Variant in CLDN16: A Further Step in the Diagnosis of Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis—A Case Report
by: Gopal Narang, et al.
Published: (2021-06-01)
by: Gopal Narang, et al.
Published: (2021-06-01)
Expression of CLDN1 and EGFR in PTC
by: JunJie Wu, et al.
Published: (2024-10-01)
by: JunJie Wu, et al.
Published: (2024-10-01)
Exploring claudin proteins: from sequence motifs to their impact on tight junction-mediated signaling pathways
by: Lingling Bao, et al.
Published: (2025-09-01)
by: Lingling Bao, et al.
Published: (2025-09-01)
Association of CLDN molecules with sleep apnea hypopnea syndrome: new biomarker candidates
by: Dan Liu, et al.
Published: (2024-02-01)
by: Dan Liu, et al.
Published: (2024-02-01)
In-Depth Bioinformatic Study of the CLDN16 Gene and Protein: Prediction of Subcellular Localization to Mitochondria
by: Erasmia Rouka, et al.
Published: (2019-07-01)
by: Erasmia Rouka, et al.
Published: (2019-07-01)
Comprehensive analysis reveals CLDN9 is a new biomarker in human cancers and immunotherapeutic target for glioblastoma multiforme
by: Yuanyuan Zhu, et al.
Published: (2025-06-01)
by: Yuanyuan Zhu, et al.
Published: (2025-06-01)
Immunotherapies targeting the oncogenic fusion gene CLDN18-ARHGAP in gastric cancer
by: Yue Wang, et al.
Published: (2024-08-01)
by: Yue Wang, et al.
Published: (2024-08-01)
Multiplex immunohistochemistry defines the tumor immune microenvironment and immunotherapeutic outcome in CLDN18.2-positive gastric cancer
by: Keren Jia, et al.
Published: (2022-07-01)
by: Keren Jia, et al.
Published: (2022-07-01)
Macrophages promote EMT of bladder cancer cells through secreting TNF-α to regulate CLDN10/β-catenin pathway
by: HAN Na, et al.
Published: (2023-08-01)
by: HAN Na, et al.
Published: (2023-08-01)
Development of a bispecific antibody–drug conjugate targeting EpCAM and CLDN3 for the treatment of multiple solid tumors
by: Meiying Luo, et al.
Published: (2025-03-01)
by: Meiying Luo, et al.
Published: (2025-03-01)
Novel compound heterozygous mutations of CLDN16 in a patient with familial hypomagnesemia with hypercalciuria and nephrocalcinosis
by: Alejandro García‐Castaño, et al.
Published: (2020-11-01)
by: Alejandro García‐Castaño, et al.
Published: (2020-11-01)
Expression and clinical significance of CLDN7 and its immune-related cells in breast cancer
by: Xiaojie Fan, et al.
Published: (2024-08-01)
by: Xiaojie Fan, et al.
Published: (2024-08-01)
Association study of CLDN14 variations in patients with kidney stones
by: Ullah Ihsan, et al.
Published: (2022-02-01)
by: Ullah Ihsan, et al.
Published: (2022-02-01)
The impact of CLDN18.2 expression on effector cells mediating antibody-dependent cellular cytotoxicity in gastric cancer
by: Akira Matsuishi, et al.
Published: (2024-08-01)
by: Akira Matsuishi, et al.
Published: (2024-08-01)
Temporal dynamics of CLDN18.2 expression following zolbetuximab treatment in advanced gastric cancer
by: K. Yamamoto, et al.
Published: (2025-09-01)
by: K. Yamamoto, et al.
Published: (2025-09-01)
CLDN1 silencing suppresses the proliferation and migration of airway smooth muscle cells by modulating MMP14
by: Wei Li, et al.
Published: (2023-12-01)
by: Wei Li, et al.
Published: (2023-12-01)
Blue light exposure collapses the inner blood-retinal barrier by accelerating endothelial CLDN5 degradation through the disturbance of GNAZ and the activation of ADAM17
by: Yen-Ju Chan, et al.
Published: (2023-04-01)
by: Yen-Ju Chan, et al.
Published: (2023-04-01)
Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model
by: Yue Hao, et al.
Published: (2024-01-01)
by: Yue Hao, et al.
Published: (2024-01-01)
The prognostic role of Claudin 18.2 in advanced gastric or gastroesophageal junction adenocarcinoma: a systematic literature review
by: M. Fassan, et al.
Published: (2025-09-01)
by: M. Fassan, et al.
Published: (2025-09-01)
Blood-Brain Barrier Dysfunction in CNS Disorders and Putative Therapeutic Targets: An Overview
by: Sabrina Rahman Archie, et al.
Published: (2021-10-01)
by: Sabrina Rahman Archie, et al.
Published: (2021-10-01)
A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer
by: Xueying Wang, et al.
Published: (2025-04-01)
by: Xueying Wang, et al.
Published: (2025-04-01)
Targeting CLDN6 in germ cell tumors by an antibody-drug-conjugate and studying therapy resistance of yolk-sac tumors to identify and screen specific therapeutic options
by: Margaretha A. Skowron, et al.
Published: (2023-03-01)
by: Margaretha A. Skowron, et al.
Published: (2023-03-01)
Claudin-9 (CLDN9) promotes gastric cancer progression by enhancing the glycolysis pathway and facilitating PD-L1 lactylation to suppress CD8+ T cell anti-tumor immunity
by: Xingbin Hu, et al.
Published: (2025-05-01)
by: Xingbin Hu, et al.
Published: (2025-05-01)
CNS Tumors and Neurofibromatosis
by: J Gordon Millichap
Published: (1989-02-01)
by: J Gordon Millichap
Published: (1989-02-01)
IL-4, IL-13, TNF-α and IFN-γ Downregulate CLDN8 Expression Through Activating JAK Signaling Pathway in HaCaT Cells
by: Wang X, et al.
Published: (2025-04-01)
by: Wang X, et al.
Published: (2025-04-01)
CLDN2 inhibits the metastasis of osteosarcoma cells via down-regulating the afadin/ERK signaling pathway
by: Xiaowei Zhang, et al.
Published: (2018-10-01)
by: Xiaowei Zhang, et al.
Published: (2018-10-01)
The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
by: Naoki Ichikawa-Tomikawa, et al.
Published: (2023-06-01)
by: Naoki Ichikawa-Tomikawa, et al.
Published: (2023-06-01)
Expression of Claudin-9 (CLDN9) in Breast Cancer, the Clinical Significance in Connection with Its Subcoat Anchorage Proteins ZO-1 and ZO-3 and Impact on Drug Resistance
by: Xinguo Zhuang, et al.
Published: (2023-11-01)
by: Xinguo Zhuang, et al.
Published: (2023-11-01)
Metastatic Cervicomedullary Lesion in the Postpartum Period: A Case-Based Review of CNS Metastases in Pregnancy and Postpartum Period
by: Sarvesh Goyal, et al.
by: Sarvesh Goyal, et al.
СURRENT CONCEPTS OF THE ROLE OF ALTERED BLOOD-BRAIN BARRIER RESISTANCE IN THE PATHOGENESIS OF CNS DISORDERS. PART II: FUNCTIONS AND MECHANISMS OF THE BLOOD-BRAIN BARRIER DAMAGE
by: D. V. Blinov
Published: (2016-05-01)
by: D. V. Blinov
Published: (2016-05-01)
CLDN18.2: a potential nanotherapeutic target for cholangiocarcinoma
by: Yu Huang, et al.
Published: (2025-03-01)
by: Yu Huang, et al.
Published: (2025-03-01)
Extrajunctional CLDN10 cooperates with LAT1 and accelerates clear cell renal cell carcinoma progression
by: Akifumi Onagi, et al.
Published: (2024-12-01)
by: Akifumi Onagi, et al.
Published: (2024-12-01)
Pan-cancer analysis of CLDN18.2 shed new insights on the targeted therapy of upper gastrointestinal tract cancers
by: Jun Wu, et al.
Published: (2024-11-01)
by: Jun Wu, et al.
Published: (2024-11-01)
High-Dose Acetaminophen Alters the Integrity of the Blood–Brain Barrier and Leads to Increased CNS Uptake of Codeine in Rats
by: Junzhi Yang, et al.
Published: (2022-04-01)
by: Junzhi Yang, et al.
Published: (2022-04-01)
Similar Items
-
Hsa-miR-31-3p targets CLDN8 to compromise skin barrier integrity in psoriasis
by: Yunhua Tu, et al.
Published: (2025-06-01) -
Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family
by: Peipei Gao, et al.
Published: (2021-06-01) -
Tight junctional protein family, Claudins in cancer and cancer metastasis
by: Wenxiao Ji, et al.
Published: (2025-07-01) -
The tight junction protein claudin 6 is a potential target for patient-individualized treatment in esophageal and gastric adenocarcinoma and is associated with poor prognosis
by: Adrian Georg Simon, et al.
Published: (2023-08-01) -
CLDN6 promotes chemoresistance through GSTP1 in human breast cancer
by: Minlan Yang, et al.
Published: (2017-11-01)
