Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports

Abstract SMARCA4, one of the subunits of the switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex, plays a pivotal role in transcriptional regulation. By disrupting histone-DNA contacts, this complex modulates gene expression patterns, and accumulating evidence suggests its tumor sup...

Full description

Bibliographic Details
Published in:	Discover Oncology
Main Authors:	Liwen Wang, Hua Ke, Chengdi Wang, Ke Wang
Format:	Article
Language:	English
Published:	Springer 2025-07-01
Subjects:	SMARCA4 Non-small cell lung carcinoma Immune checkpoint inhibitor Sintilimab Chemotherapy
Online Access:	https://doi.org/10.1007/s12672-025-03060-7

Similar Items

Evaluation of Efficacy and Prognosis Analysis of Stage III-IV SMARCA4-deficient  Non-small Cell Lung Cancer Treated by PD-1 Immune Checkpoint Inhibitors plus  Chemotherapy and Chemotherapy
by: Xinjuan WANG, et al.
Published: (2023-09-01)

A case report of SMARCA2-deficient and SMARCA4-preserved lung adenocarcinoma diagnosed by pleural effusion cytology
by: Xiaoyue Feng, et al.
Published: (2025-08-01)

Case report: Heterogenous SMARCA4-deficient thoracic non-small cell lung carcinoma with various responses to nivolumab
by: Yun-Tzu Lin, et al.
Published: (2023-03-01)

SMARCA4-deficient non-small cell lung cancer: Clinicopathological features of five cases
by: Hairen Chen, et al.
Published: (2025-10-01)

Successful neoadjuvant chemotherapy plus sintilimab for locally advanced cervical cancer: case series and review of the literature
by: Linlin Liu, et al.
Published: (2023-09-01)

Case Report: FAP+ fibroblasts and SPP1+ macrophages in SMARCA2-deficient while SMARCA4-preserved poorly differentiated lung adenocarcinoma: two case reports and multi-omics analysis
by: Zhaoxuan Wang, et al.
Published: (2025-05-01)

Concurrent SMARCA4-deficient and poorly differentiated adenocarcinomas in separate lung lobes: a case report and literature review
by: Lu Wang, et al.
Published: (2025-05-01)

Sintilimab for the treatment of lung adenocarcinoma-induced immune-related hypophysitis: a case report
by: Ming-xing Wang, et al.
Published: (2025-01-01)

Toxic Epidermal Necrolysis and Stevens - Johnson Syndrome Following Sintilimab Administration in a Non-Small Cell Lung Cancer Patient: A Case Report
by: Jiang Z, et al.
Published: (2023-11-01)

Immune Thrombocytopenia Induced by Sintilimab in Lung Cancer:  A Case Report and Literature Review
by: Jingjing CAI, et al.
Published: (2023-09-01)

Marked Response to Nivolumab by a Patient With SMARCA4‐Deficient Undifferentiated Urothelial Carcinoma Showing High PD‐L1 Expression: A Case Report
by: Yohei Arihara, et al.
Published: (2024-06-01)

SMARCA4/SMARCA2-Deficient Undifferentiated Metastatic Malignant Tumor with Carcinoma of Unknown Primary: Case Report
by: Amanda Craven, et al.
Published: (2024-07-01)

TTF1-positive SMARCA4/BRG1 deficient lung adenocarcinoma
by: Anurag Mehta, et al.
Published: (2022-01-01)

Thoracic SMARCA4‐deficient undifferentiated tumour: Diagnostic challenges and potential for misdiagnosis in small tissue samples
by: Deborah Johanna Maartens, et al.
Published: (2023-11-01)

Metastatic SMARCA4-deficient undifferentiated tumor in the small mesentery: case report
by: Shuai Luo, et al.
Published: (2024-12-01)

Transformation of Thoracic SMARCA4‐Deficient Undifferentiated Tumour to Squamous Cell Carcinoma: A Case Report
by: Heng You, et al.
Published: (2025-09-01)

Case report: A rare case of anti-PD-1 sintilimab-induced agranulocytosis/severe neutropenia in non-small cell lung cancer and literature review
by: Yanzhu Qin, et al.
Published: (2024-06-01)

A case of poorly differentiated lung adenocarcinoma with SMARCA4 gene deletion
by: Chi Zhang, et al.
Published: (2025-08-01)

Long-term follow-up of combination therapy with pembrolizumab and anlotinib in thoracic SMARCA4-deficient undifferentiated tumor: a case report and molecular features
by: Ting Duan, et al.
Published: (2024-12-01)

Sintilimab combined with anlotinib as first-line treatment for advanced sarcomatoid carcinoma of head and neck: a case report and literature review
by: Lei Wang, et al.
Published: (2024-04-01)

Thoracic SMARCA4-deficient undifferentiated tumour – a case of an aggressive neoplasm
by: Gizem Teoman
Published: (2025-04-01)

Refractory pruritus caused by sintilimab and its clinical management: A case report
by: Li Chen, et al.
Published: (2024-07-01)

Case Report: Successful treatment of triple primary cancers (lung, stomach, and intestine) using sintilimab combined with chemotherapy and targeted therapy
by: Qi-Qing Zhang, et al.
Published: (2025-08-01)

Thoracic SMARCA4-deficient tumors: a clinicopathological analysis of 52 cases with SMARCA4-deficient non-small cell lung cancer and 20 cases with thoracic SMARCA4-deficient undifferentiated tumor
by: Ping Zhou, et al.
Published: (2024-02-01)

An aggressive case of a thoracic undifferentiated SMARCA4‐deficient tumor with extensive pleural involvement
by: Paul F. Hanona, et al.
Published: (2024-04-01)

Case Report: Ensartinib as a first-line treatment for SMARCA4-deficient and EML4-ALK non-small cell lung cancer
by: Yanqing Pan, et al.
Published: (2025-05-01)

A case of surgically treated non-metastatic SMARCA4-deficient undifferentiated thoracic tumor: a case report and literature review
by: Cong Yin, et al.
Published: (2024-06-01)

Case Report: A rare case of sintilimab-induced dermatomyositis in a patient with gastric cancer
by: Peipei Mou, et al.
Published: (2025-04-01)

Successful treatment with tislelizumab plus chemotherapy for SMARCA4-deficient undifferentiated tumor: a case report
by: Wen Dong, et al.
Published: (2024-05-01)

Research Progress on SMARCA4 Mutation Non-small Cell Lung Cancer
by: Lishan PENG, et al.
Published: (2024-09-01)

Bladder SMARCA4-deficient sarcoma: A case report
by: Tianyun Wang, et al.
Published: (2025-04-01)

Perspectives and Issues in the Assessment of <i>SMARCA4</i> Deficiency in the Management of Lung Cancer Patients
by: Subasri Armon, et al.
Published: (2021-07-01)

Case Report: Prognostic evaluation of immunotherapy in two patients with SMARCA4-UT using TCR as a new marker
by: Xiayu Wang, et al.
Published: (2025-09-01)

SMARCA4-deficient non-small cell lung cancer with metastasis to the sigmoid colon: a case report
by: Rong Xiao, et al.
Published: (2025-03-01)

Correction: Case Report: Prognostic evaluation of immunotherapy in two patients with SMARCA4-UT using TCR as a new marker
by: Xiayu Wang, et al.
Published: (2025-10-01)

Donafenib combined with sintilimab for advanced hepatocellular carcinoma: a single arm phase II trial
by: Xiaoyang Hong, et al.
Published: (2025-02-01)

SMARCA4-deficient tumors in the adrenal gland and small intestines: A rare case report
by: Akira Kambe, MD, et al.
Published: (2024-02-01)

Diagnosis of a SMARCA4‐deficient undifferentiated tumor using multigene panel testing: A case report
by: Yoshiaki Marumo, et al.
Published: (2023-09-01)

Rapid Response to Penpulimab Combined With Anlotinib and Chemotherapy in a Thoracic SMARCA4‐UT Without PD‐L1 Expression: A Case Report and Review of Literature
by: Yuanhang Wang, et al.
Published: (2024-12-01)

Thoracic SMARCA4-deficient undifferentiated tumor
by: Jiapeng Jiang, et al.
Published: (2023-04-01)