Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin

Metformin is a widely used antidiabetic drug for cancer prevention and treatment. However, the overproduction of lactic acid and its inefficiency in cancer therapy limit its application. Here, we demonstrate the synergistic effects of the lactate/GPR81 blockade (3-hydroxy-butyrate, 3-OBA) and metfor...

書誌詳細
出版年:	Biomolecules
主要な著者:	Shaomeng Chen, Xiuman Zhou, Xin Yang, Wanqiong Li, Shuzhen Li, Zheng Hu, Chen Ling, Ranran Shi, Juan Liu, Guanyu Chen, Nazi Song, Xianxing Jiang, Xinghua Sui, Yanfeng Gao
フォーマット:	論文
言語:	英語
出版事項:	MDPI AG 2021-09-01
主題:	metformin GPR81 lactate cancer immunotherapy PD-1/PD-L1 blockade
オンライン･アクセス:	https://www.mdpi.com/2218-273X/11/9/1373

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