Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants
Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 gen...
| الحاوية / القاعدة: | International Journal of Infectious Diseases |
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| المؤلفون الرئيسيون: | , , , , , , , , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Elsevier
2020-09-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://www.sciencedirect.com/science/article/pii/S1201971220305609 |
| _version_ | 1852747008071172096 |
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| author | Eric de Sousa Dário Ligeiro Joana R. Lérias Chao Zhang Chiara Agrati Mohamed Osman Sherif A. El-Kafrawy Esam I. Azhar Giuseppe Ippolito Fu-Sheng Wang Alimuddin Zumla Markus Maeurer |
| author_facet | Eric de Sousa Dário Ligeiro Joana R. Lérias Chao Zhang Chiara Agrati Mohamed Osman Sherif A. El-Kafrawy Esam I. Azhar Giuseppe Ippolito Fu-Sheng Wang Alimuddin Zumla Markus Maeurer |
| author_sort | Eric de Sousa |
| collection | DOAJ |
| container_title | International Journal of Infectious Diseases |
| description | Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We caracterized how a single mutation in the wildtype sequence of of SARS-CoV-2 could influence the peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles. Assuming the ORF8 (L84S) mutation is biologically significant, selective pressure from MHC class II alleles may select for viral varients and subsequently shape the quality and quantity of cellular immune responses aginast SARS-CoV-2. MHC 4-digit typing along with viral sequence analysis should be considered in studies examining clinical outcomes in patients with COVID-19. |
| format | Article |
| id | doaj-art-7084a31eedf64e61ba7af0a661edb563 |
| institution | Directory of Open Access Journals |
| issn | 1201-9712 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-7084a31eedf64e61ba7af0a661edb5632025-08-19T21:01:58ZengElsevierInternational Journal of Infectious Diseases1201-97122020-09-019845445910.1016/j.ijid.2020.07.016Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variantsEric de Sousa0Dário Ligeiro1Joana R. Lérias2Chao Zhang3Chiara Agrati4Mohamed Osman5Sherif A. El-Kafrawy6Esam I. Azhar7Giuseppe Ippolito8Fu-Sheng Wang9Alimuddin Zumla10Markus Maeurer11ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, PortugalLisbon Centre for Blood and Transplantation (Instituto Português do Sangue e Transplantação, IPST, Lisbon, PortugalImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, PortugalTreatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, ChinaNational Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, ItalyYork Biomedical Research Institute, University of York, United Kingdom and Emerging and Re-Emerging Diseases, University of Khartoum, SudanSpecial Infectious Agent Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaSpecial Infectious Agent Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi ArabiaNational Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, ItalyTreatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, ChinaDivision of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UKImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal; I Medical Clinical, University of Mainz, Germany; Corresponding author at: Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal.Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We caracterized how a single mutation in the wildtype sequence of of SARS-CoV-2 could influence the peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles. Assuming the ORF8 (L84S) mutation is biologically significant, selective pressure from MHC class II alleles may select for viral varients and subsequently shape the quality and quantity of cellular immune responses aginast SARS-CoV-2. MHC 4-digit typing along with viral sequence analysis should be considered in studies examining clinical outcomes in patients with COVID-19.http://www.sciencedirect.com/science/article/pii/S1201971220305609SARS-CoV-2COVID-19SARST-cellsMHCHLA |
| spellingShingle | Eric de Sousa Dário Ligeiro Joana R. Lérias Chao Zhang Chiara Agrati Mohamed Osman Sherif A. El-Kafrawy Esam I. Azhar Giuseppe Ippolito Fu-Sheng Wang Alimuddin Zumla Markus Maeurer Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants SARS-CoV-2 COVID-19 SARS T-cells MHC HLA |
| title | Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants |
| title_full | Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants |
| title_fullStr | Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants |
| title_full_unstemmed | Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants |
| title_short | Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants |
| title_sort | mortality in covid 19 disease patients correlating the association of major histocompatibility complex mhc with severe acute respiratory syndrome 2 sars cov 2 variants |
| topic | SARS-CoV-2 COVID-19 SARS T-cells MHC HLA |
| url | http://www.sciencedirect.com/science/article/pii/S1201971220305609 |
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