Effect of acupuncture on episodic memory for amnestic mild cognitive impairment based on hippocampal subregion: study protocol of a randomized, controlled trial

BackgroundThe hippocampus is a key brain region for episodic memory, and impairment of episodic memory is the earliest feature of amnestic mild cognitive impairment (aMCI). Preserving the structure and function of the hippocampus plays a key role in preventing progression to Alzheimer’s disease (AD)...

Full description

Bibliographic Details
Published in:	Frontiers in Neurology
Main Authors:	Xinbei Li, Xingying Lu, Juan Ou, Hanqing Lyu, Yongfeng Liu, Jinhuan Zhang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Subjects:	amnestic mild cognitive impairment acupuncture episodic memory hippocampal subregions randomized controlled trial protocol
Online Access:	https://www.frontiersin.org/articles/10.3389/fneur.2025.1536291/full

Similar Items

Selective Plasticity of Hippocampal Sub‐Regions in the Amnestic Mild Cognitive Impairment After Acupuncture
by: Jinhuan Zhang, et al.
Published: (2025-08-01)

Episodic memory network characteristics in patients with amnestic mild cognitive impairment accompanied by executive function impairment
by: Chao Wang, et al.
Published: (2024-06-01)

Acupuncture-induced changes in locus coeruleus connectivity and memory improvement in patients with amnestic cognitive impairment
by: Liyu Hu, et al.
Published: (2026-06-01)

Machine learning classifiers and associations of cognitive performance with hippocampal subfields in amnestic mild cognitive impairment
by: Qi Feng, et al.
Published: (2023-11-01)

Altered Whole-Brain Structural Covariance of the Hippocampal Subfields in Subcortical Vascular Mild Cognitive Impairment and Amnestic Mild Cognitive Impairment Patients
by: Xuetong Wang, et al.
Published: (2018-05-01)

Potential Value of Plasma-Based Biomarkers for Prediction of Episodic Memory Performance and Identification of Individuals with Amnestic Mild Cognitive Impairment
by: Wang M, et al.
Published: (2025-05-01)

Clinical observation and mechanism of acupuncture on amnestic mild cognitive impairment based on the gut-brain axis: study protocol for a randomized controlled trial
by: Qiongnan Bao, et al.
Published: (2023-06-01)

Exploring the changes in functional connectivity of the limbic system in Patients with amnestic mild cognitive impairment treated by acupuncture based on fMRI
by: Han Yingmei, et al.
Published: (2025-06-01)

Functional-structural co-dependent brain mapping of metamemory in amnestic mild cognitive impairment
by: Juan-Juan Lu, et al.
Published: (2025-07-01)

Discovery of the microbiota-gut-brain axis mechanisms of acupuncture for amnestic mild cognitive impairment based on multi-omics analyses: A pilot study
by: Zi-Han Yin, et al.
Published: (2025-03-01)

Macrostructural and microstructural alterations of hippocampal subregions in T2DM: NODDI provides added value to DTI and volumetric analyses
by: Xuan Huang, et al.
Published: (2025-08-01)

Hippocampal atrophy and verbal episodic memory performance in amnestic mild cognitive impairment and mild Alzheimer's disease: A preliminary study
by: Nathalia Carollina Peruzza Marchiani, et al.

Disturbances in Resting State Functional Connectivity in Schizophrenia: A Study of Hippocampal Subregions, the Parahippocampal Gyrus and Functional Brain Networks
by: Raghad M. Makhdoum, et al.
Published: (2025-08-01)

Baduanjin exercise modulates the hippocampal subregion structure in community-dwelling older adults with cognitive frailty
by: Mingyue Wan, et al.
Published: (2022-12-01)

Disrupted Functional Connectivity of Cornu Ammonis Subregions in Amnestic Mild Cognitive Impairment: A Longitudinal Resting-State fMRI Study
by: Hui Li, et al.
Published: (2018-10-01)

Absolute substrate oxidation rates are lower in older adults with amnestic mild cognitive impairment
by: Nicholas A. Rizzi, et al.
Published: (2025-04-01)

Brain structural and functional aberrant of hippocampal subregions was associated with somatic depression
by: Qiao Juan, et al.
Published: (2025-10-01)

Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment
by: Jiong Zhou, et al.
Published: (2016-01-01)

The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment
by: Xiwu Wang, et al.
Published: (2019-02-01)

Quantitative and Qualitative Assessment of Verbal Fluency in Amnestic Mild Cognitive Impairment
by: Tuğçe Çabuk, et al.
Published: (2020-09-01)

Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment
by: Qing Ye, et al.
Published: (2021-11-01)

Comparison of performance on neuropsychological tests in amnestic Mild Cognitive Impairment and Alzheimer's disease patients
by: Patrícia Helena Figueirêdo do Vale, et al.

Using voxel-based morphometry to examine the relationship between regional brain volumes and memory performance in amnestic mild cognitive impairment
by: Patric eMeyer, et al.
Published: (2013-07-01)

Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials
by: Guangyao Lin, et al.
Published: (2025-03-01)

Gray Matter Atrophy in Amnestic Mild Cognitive Impairment: A Voxel-Based Meta-Analysis
by: Jinhuan Zhang, et al.
Published: (2021-03-01)

Divergent brain regional atrophy and associated fiber disruption in amnestic and non-amnestic MCI
by: Chao Du, et al.
Published: (2023-11-01)

Neuropsychological test-based risk prediction of conversion to dementia in amnestic mild cognitive impairment patients: a personal view
by: Jun Pyo Kim, et al.
Published: (2018-06-01)

The differentiation of amnestic type MCI from the non-amnestic types by structural MRI
by: Gábor eCsukly, et al.
Published: (2016-03-01)

Effect of acupuncture on episodic memory for amnesia-type mild cognitive impairment: study protocol of a multicenter, randomized, controlled trial
by: Yalan Dai, et al.
Published: (2023-07-01)

Deficits in episodic memory retrieval reveal impaired default mode network connectivity in amnestic mild cognitive impairment
by: Cameron J. Dunn, et al.
Published: (2014-01-01)

Chinese herbal medicine Qinggongshoutao for the treatment of amnestic mild cognitive impairment: A 52‐week randomized controlled trial
by: Jinzhou Tian, et al.
Published: (2019-01-01)

Altered Insular Subregional Connectivity Associated With Cognitions for Distinguishing the Spectrum of Pre-clinical Alzheimer's Disease
by: Siyu Wang, et al.
Published: (2021-02-01)

Neural correlates of saccadic inhibition in healthy elderly and patients with amnestic mild cognitive impairment
by: Karolina K Alichniewicz, et al.
Published: (2013-07-01)

Trajectories of the Hippocampal Subfields Atrophy in the Alzheimer’s Disease: A Structural Imaging Study
by: Weina Zhao, et al.
Published: (2019-03-01)

Wearable Sensor-Based Daily Life Walking Assessment of Gait for Distinguishing Individuals With Amnestic Mild Cognitive Impairment
by: Haiqun Xie, et al.
Published: (2019-10-01)

An EEG-based framework for automated discrimination of conversion to Alzheimer’s disease in patients with amnestic mild cognitive impairment: an 18-month longitudinal study
by: Yingfeng Ge, et al.
Published: (2025-01-01)

Prevalence, cognitive characteristics, and influencing factors of amnestic mild cognitive impairment among older adults residing in an urban community in Chengdu, China
by: Shan Rao, et al.
Published: (2024-01-01)

High Fall Risk Associated With Memory Deficit and Brain Lobes Atrophy Among Elderly With Amnestic Mild Cognitive Impairment and Mild Alzheimer’s Disease
by: Shuyun Huang, et al.
Published: (2022-06-01)

Diminishing accelerated long-term forgetting in mild cognitive impairment: Study protocol for a prospective, double-blind, placebo-controlled, randomized controlled trial
by: Katherine S. Adcock, et al.
Published: (2022-12-01)

The overall impairment of core executive function components in patients with amnestic mild cognitive impairment: a cross-sectional study
by: Zheng Dongming, et al.
Published: (2012-11-01)