ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin

ATM abnormalities are frequent in chronic lymphocytic leukemia and represent an important prognostic factor. Sole 11q deletion does not result in ATM inactivation by contrast to biallelic defects involving mutations. Therefore, the analysis of ATM mutations and their functional impact is crucial. In...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Haematologica
المؤلفون الرئيسيون:	Veronika Navrkalova, Ludmila Sebejova, Jana Zemanova, Jana Kminkova, Blanka Kubesova, Jitka Malcikova, Marek Mraz, Jana Smardova, Sarka Pavlova, Michael Doubek, Yvona Brychtova, David Potesil, Veronika Nemethova, Jiri Mayer, Sarka Pospisilova, Martin Trbusek
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Ferrata Storti Foundation 2013-07-01
الوصول للمادة أونلاين:	https://haematologica.org/article/view/6723

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