Synthesis and biomedical applications of nanoceria, a redox active nanoparticle
Abstract Background Nanoceria has recently received much attention, because of its widespread biomedical applications, including antibacterial, antioxidant and anticancer activity, drug/gene delivery systems, anti-diabetic property, and tissue engineering. Main body Nanoceria exhibits excellent anti...
| Published in: | Journal of Nanobiotechnology |
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| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2019-07-01
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| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-019-0516-9 |
| _version_ | 1852765566982422528 |
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| author | Neelam Thakur Prasenjit Manna Joydeep Das |
| author_facet | Neelam Thakur Prasenjit Manna Joydeep Das |
| author_sort | Neelam Thakur |
| collection | DOAJ |
| container_title | Journal of Nanobiotechnology |
| description | Abstract Background Nanoceria has recently received much attention, because of its widespread biomedical applications, including antibacterial, antioxidant and anticancer activity, drug/gene delivery systems, anti-diabetic property, and tissue engineering. Main body Nanoceria exhibits excellent antibacterial activity against both Gram-positive and Gram-negative bacteria via the generation of reactive oxygen species (ROS). In healthy cells, it acts as an antioxidant by scavenging ROS (at physiological pH). Thus, it protects them, while in cancer cells (under low pH environment) it acts as pro-oxidant by generating ROS and kills them. Nanoceria has also been effectively used as a carrier for targeted drug and gene delivery in vitro and in vivo models. Besides, nanoceria can also act as an antidiabetic agent and confer protection towards diabetes-associated organ pathophysiology via decreasing the ROS level in diabetic subjects. Nanoceria also possesses excellent potential in the field of tissue engineering. In this review, firstly, we have discussed the different methods used for the synthesis of nanoceria as these are very important to control the size, shape and Ce3+/Ce4+ ratio of the particles upon which the physical, chemical, and biological properties depend. Secondly, we have extensively reviewed the different biomedical applications of nanoceria with probable mechanisms based on the literature reports. Conclusion The outcome of this review will improve the understanding about the different synthetic procedures and biomedical applications of nanoceria, which should, in turn, lead to the design of novel clinical interventions associated with various health disorders. Graphical abstract |
| format | Article |
| id | doaj-art-71663b7172e94b6d8ace48b31f0200de |
| institution | Directory of Open Access Journals |
| issn | 1477-3155 |
| language | English |
| publishDate | 2019-07-01 |
| publisher | BMC |
| record_format | Article |
| spelling | doaj-art-71663b7172e94b6d8ace48b31f0200de2025-08-19T20:53:56ZengBMCJournal of Nanobiotechnology1477-31552019-07-0117112710.1186/s12951-019-0516-9Synthesis and biomedical applications of nanoceria, a redox active nanoparticleNeelam Thakur0Prasenjit Manna1Joydeep Das2School of Chemistry, Shoolini University of Biotechnology and Management SciencesBiological Science and Technology Division, CSIR-North East Institute of Science and TechnologySchool of Chemistry, Shoolini University of Biotechnology and Management SciencesAbstract Background Nanoceria has recently received much attention, because of its widespread biomedical applications, including antibacterial, antioxidant and anticancer activity, drug/gene delivery systems, anti-diabetic property, and tissue engineering. Main body Nanoceria exhibits excellent antibacterial activity against both Gram-positive and Gram-negative bacteria via the generation of reactive oxygen species (ROS). In healthy cells, it acts as an antioxidant by scavenging ROS (at physiological pH). Thus, it protects them, while in cancer cells (under low pH environment) it acts as pro-oxidant by generating ROS and kills them. Nanoceria has also been effectively used as a carrier for targeted drug and gene delivery in vitro and in vivo models. Besides, nanoceria can also act as an antidiabetic agent and confer protection towards diabetes-associated organ pathophysiology via decreasing the ROS level in diabetic subjects. Nanoceria also possesses excellent potential in the field of tissue engineering. In this review, firstly, we have discussed the different methods used for the synthesis of nanoceria as these are very important to control the size, shape and Ce3+/Ce4+ ratio of the particles upon which the physical, chemical, and biological properties depend. Secondly, we have extensively reviewed the different biomedical applications of nanoceria with probable mechanisms based on the literature reports. Conclusion The outcome of this review will improve the understanding about the different synthetic procedures and biomedical applications of nanoceria, which should, in turn, lead to the design of novel clinical interventions associated with various health disorders. Graphical abstracthttp://link.springer.com/article/10.1186/s12951-019-0516-9NanoceriaAntibacterial activityAntioxidant activityAnti-cancer activityDrug/gene deliveryAnti-diabetic effect |
| spellingShingle | Neelam Thakur Prasenjit Manna Joydeep Das Synthesis and biomedical applications of nanoceria, a redox active nanoparticle Nanoceria Antibacterial activity Antioxidant activity Anti-cancer activity Drug/gene delivery Anti-diabetic effect |
| title | Synthesis and biomedical applications of nanoceria, a redox active nanoparticle |
| title_full | Synthesis and biomedical applications of nanoceria, a redox active nanoparticle |
| title_fullStr | Synthesis and biomedical applications of nanoceria, a redox active nanoparticle |
| title_full_unstemmed | Synthesis and biomedical applications of nanoceria, a redox active nanoparticle |
| title_short | Synthesis and biomedical applications of nanoceria, a redox active nanoparticle |
| title_sort | synthesis and biomedical applications of nanoceria a redox active nanoparticle |
| topic | Nanoceria Antibacterial activity Antioxidant activity Anti-cancer activity Drug/gene delivery Anti-diabetic effect |
| url | http://link.springer.com/article/10.1186/s12951-019-0516-9 |
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