pyHiM: a new open-source, multi-platform software package for spatial genomics based on multiplexed DNA-FISH imaging

Abstract Genome-wide ensemble sequencing methods improved our understanding of chromatin organization in eukaryotes but lack the ability to capture single-cell heterogeneity and spatial organization. To overcome these limitations, new imaging-based methods have emerged, giving rise to the field of s...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Xavier Devos, Jean-Bernard Fiche, Marion Bardou, Olivier Messina, Christophe Houbron, Julian Gurgo, Marie Schaeffer, Markus Götz, Thomas Walter, Florian Mueller, Marcelo Nollmann
Format:	Article
Language:	English
Published:	BMC 2024-02-01
Subjects:	Spatial genomics 3D chromatin structure Transcription Imaging Bioimage informatics
Online Access:	https://doi.org/10.1186/s13059-024-03178-x