Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report
Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndr...
| Published in: | Revista Portuguesa de Nefrologia e Hipertensão |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Publicações Ciência e Vida
2023-06-01
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| Subjects: | |
| Online Access: | https://spnefro.pt/_doi/reference/116f1a1e-6e92-4c93-beaf-5655b1a67dab |
| Summary: | Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication.
We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The
patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was
performed, showing minimal change disease with lymphomatous infiltration of B-lymphocytes CD20+. Therapy with bortezomib, dexametahasone and rituximab was started and after 6 months of follow-up he presented progressive recovery of renal function and remission
of proteinuria.
This case illustrates the importance of screening renal disease in WM patients. A kidney biopsy should be performed in those presenting
with otherwise unexplained renal failure and/or nephrotic syndrome. |
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| ISSN: | 0872-0169 2183-1289 |