Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples
Amygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high- and low-familial likelihood for ASD, Infant Brai...
| 出版年: | Developmental Cognitive Neuroscience |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Elsevier
2024-02-01
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| 主題: | |
| オンライン･アクセス: | http://www.sciencedirect.com/science/article/pii/S187892932300138X |
| _version_ | 1850147499368513536 |
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| author | Catherine A. Burrows Carolyn Lasch Julia Gross Jessica B. Girault Joshua Rutsohn Jason J. Wolff Meghan R. Swanson Chimei M. Lee Stephen R. Dager Emil Cornea Rebecca Stephens Martin Styner Tanya St. John Juhi Pandey Meera Deva Kelly N. Botteron Annette M. Estes Heather C. Hazlett John R. Pruett, Jr. Robert T. Schultz Lonnie Zwaigenbaum John H. Gilmore Mark D. Shen Joseph Piven Jed T. Elison |
| author_facet | Catherine A. Burrows Carolyn Lasch Julia Gross Jessica B. Girault Joshua Rutsohn Jason J. Wolff Meghan R. Swanson Chimei M. Lee Stephen R. Dager Emil Cornea Rebecca Stephens Martin Styner Tanya St. John Juhi Pandey Meera Deva Kelly N. Botteron Annette M. Estes Heather C. Hazlett John R. Pruett, Jr. Robert T. Schultz Lonnie Zwaigenbaum John H. Gilmore Mark D. Shen Joseph Piven Jed T. Elison |
| author_sort | Catherine A. Burrows |
| collection | DOAJ |
| container_title | Developmental Cognitive Neuroscience |
| description | Amygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high- and low-familial likelihood for ASD, Infant Brain Imaging Study (IBIS, n = 257) and typically developing (TD) community sample, Early Brain Development Study (EBDS, n = 158). Infants underwent MRI scanning at up to 3 timepoints from neonate to 24 months. Anxiety was assessed at 6–12 years. Linear multilevel modeling tested whether amygdala volume growth was associated with anxiety symptoms at school age. In the IBIS sample, children with higher anxiety showed accelerated amygdala growth from 6 to 24 months. ASD diagnosis and ASD familial likelihood were not significant predictors. In the EBDS sample, amygdala growth from birth to 24 months was associated with anxiety. More anxious children had smaller amygdala volume and slower rates of amygdala growth. We explore reasons for the contrasting results between high-familial likelihood for ASD and TD samples, grounding results in the broader literature of variable associations between early amygdala volume and later anxiety. Results have the potential to identify mechanisms linking early amygdala growth to later anxiety in certain groups. |
| format | Article |
| id | doaj-art-72d4bee043bb4e07bdab48bca710de56 |
| institution | Directory of Open Access Journals |
| issn | 1878-9293 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| spelling | doaj-art-72d4bee043bb4e07bdab48bca710de562025-08-19T23:46:44ZengElsevierDevelopmental Cognitive Neuroscience1878-92932024-02-016510133310.1016/j.dcn.2023.101333Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samplesCatherine A. Burrows0Carolyn Lasch1Julia Gross2Jessica B. Girault3Joshua Rutsohn4Jason J. Wolff5Meghan R. Swanson6Chimei M. Lee7Stephen R. Dager8Emil Cornea9Rebecca Stephens10Martin Styner11Tanya St. John12Juhi Pandey13Meera Deva14Kelly N. Botteron15Annette M. Estes16Heather C. Hazlett17John R. Pruett, Jr.18Robert T. Schultz19Lonnie Zwaigenbaum20John H. Gilmore21Mark D. Shen22Joseph Piven23Jed T. Elison24Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Correspondence to: Masonic Institute for the Developing Brain, 2025 E River Pkwy, Minneapolis, MN 55414, USA.Institute of Child Development, University of Minnesota, Minneapolis, MN, USACarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USACarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USADepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USADepartment of Educational Psychology, University of Minnesota, Minneapolis, MN, USASchool of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USADepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USADeptartment of Radiology, University of Washington Medical Center, Seattle, WA, USACenter for Autism Research, Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USADepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USADepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USAUniversity of Washington Autism Center, University of Washington, Seattle, WA, USACenter for Autism Research, Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USADepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USADepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USAUniversity of Washington Autism Center, University of Washington, Seattle, WA, USA; Deptartment of Speech and Hearing Science, University of Washington, Seattle, WA, USACarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USADepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, MO, USACenter for Autism Research, Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USADeptartment of Pediatrics, University of Alberta, Edmonton, AB, CanadaDepartment of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USACarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA; Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USACarolina Institute for Developmental Disabilities and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USADepartment of Pediatrics, University of Minnesota, Minneapolis, MN, USA; Institute of Child Development, University of Minnesota, Minneapolis, MN, USAAmygdala function is implicated in the pathogenesis of autism spectrum disorder (ASD) and anxiety. We investigated associations between early trajectories of amygdala growth and anxiety and ASD outcomes at school age in two longitudinal studies: high- and low-familial likelihood for ASD, Infant Brain Imaging Study (IBIS, n = 257) and typically developing (TD) community sample, Early Brain Development Study (EBDS, n = 158). Infants underwent MRI scanning at up to 3 timepoints from neonate to 24 months. Anxiety was assessed at 6–12 years. Linear multilevel modeling tested whether amygdala volume growth was associated with anxiety symptoms at school age. In the IBIS sample, children with higher anxiety showed accelerated amygdala growth from 6 to 24 months. ASD diagnosis and ASD familial likelihood were not significant predictors. In the EBDS sample, amygdala growth from birth to 24 months was associated with anxiety. More anxious children had smaller amygdala volume and slower rates of amygdala growth. We explore reasons for the contrasting results between high-familial likelihood for ASD and TD samples, grounding results in the broader literature of variable associations between early amygdala volume and later anxiety. Results have the potential to identify mechanisms linking early amygdala growth to later anxiety in certain groups.http://www.sciencedirect.com/science/article/pii/S187892932300138XAutism spectrum disorder (ASD)AnxietyAmygdalaReproducibilityMagnetic resonance imaging (MRI) |
| spellingShingle | Catherine A. Burrows Carolyn Lasch Julia Gross Jessica B. Girault Joshua Rutsohn Jason J. Wolff Meghan R. Swanson Chimei M. Lee Stephen R. Dager Emil Cornea Rebecca Stephens Martin Styner Tanya St. John Juhi Pandey Meera Deva Kelly N. Botteron Annette M. Estes Heather C. Hazlett John R. Pruett, Jr. Robert T. Schultz Lonnie Zwaigenbaum John H. Gilmore Mark D. Shen Joseph Piven Jed T. Elison Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples Autism spectrum disorder (ASD) Anxiety Amygdala Reproducibility Magnetic resonance imaging (MRI) |
| title | Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples |
| title_full | Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples |
| title_fullStr | Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples |
| title_full_unstemmed | Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples |
| title_short | Associations between early trajectories of amygdala development and later school-age anxiety in two longitudinal samples |
| title_sort | associations between early trajectories of amygdala development and later school age anxiety in two longitudinal samples |
| topic | Autism spectrum disorder (ASD) Anxiety Amygdala Reproducibility Magnetic resonance imaging (MRI) |
| url | http://www.sciencedirect.com/science/article/pii/S187892932300138X |
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