Three New Multiflorane-Type Triterpenes from Pumpkin (Cucurbita maxima) Seeds

Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with th...

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Bibliographic Details
Published in:Molecules
Main Authors: Reiko Tanaka, Takeshi Yamada, Mayumi Shinto, Mika Takebayashi, Takashi Kikuchi
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Subjects:
Cucurbita maxima
multiflorane-type triterpenes
melanogenesis inhibitory activity
cytotoxic activity
Online Access:http://www.mdpi.com/1420-3049/18/5/5568
Description
Summary:Three new multiflorane-type triterpenes; 7a-methoxymultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (1), 7-oxomultiflor-8-ene-3a,29-diol 3-acetate-29-benzoate (2), and multiflora-7,9(11)-diene-3a,29-diol 3-p-hydroxybenzoate-29-benzoate (3), were isolated from seeds of Cucurbita maxima, along with three known compounds. Compound 3 and multiflora-7,9(11)-diene-3a-29-diol 3-benzoate (5) exhibited potent inhibitory effects on melanogenesis, with low cytotoxicities, and 2 exhibited single-digit micromolar cytotoxicity against HL-60 and P388 cells.
ISSN:1420-3049

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