Fatty acid metabolism in ischemic stroke: multi-omics biomarker discovery and therapeutic potential of GPR84
Abstract Objective Ischemic stroke (IS), a leading cause of global disability and premature mortality, results from cerebral artery occlusion and subsequent ischemic necrosis. Fatty acid metabolism (FAM) plays a crucial role in energy supply and oxidative damage associated with IS, yet reliable biom...
| Published in: | BMC Medical Genomics |
|---|---|
| Main Authors: | Jun Wu, Da Wu, Ming Qi, Kuan Jiang |
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-09-01
|
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12920-025-02212-6 |
Similar Items
Multi-Omics and Experimental Validation Identify GPX7 and Glutathione-Associated Oxidative Stress as Potential Biomarkers in Ischemic Stroke
by: Tianzhi Li, et al.
Published: (2025-05-01)
by: Tianzhi Li, et al.
Published: (2025-05-01)
Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms
by: Fangyuan Cheng, et al.
Published: (2025-09-01)
by: Fangyuan Cheng, et al.
Published: (2025-09-01)
The role of inflammation in Ischemic stroke: from biomarker to treatment
by: Liangyi Xiao, et al.
Published: (2025-09-01)
by: Liangyi Xiao, et al.
Published: (2025-09-01)
Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke
by: Tianzhi Li, et al.
Published: (2025-03-01)
by: Tianzhi Li, et al.
Published: (2025-03-01)
Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy
by: Jingwei Song, et al.
Published: (2023-11-01)
by: Jingwei Song, et al.
Published: (2023-11-01)
Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis
by: Tianyu Zhang, et al.
Published: (2025-07-01)
by: Tianyu Zhang, et al.
Published: (2025-07-01)
Integrating machine learning and single-cell transcriptomic analysis to identify potential biomarkers and analyze immune features of ischemic stroke
by: Yaowei Zhao, et al.
Published: (2024-10-01)
by: Yaowei Zhao, et al.
Published: (2024-10-01)
Genetic plasma biomarkers associated with ischemic stroke
by: Mihai Andrei Ruscu, et al.
Published: (2023-02-01)
by: Mihai Andrei Ruscu, et al.
Published: (2023-02-01)
COMPARISON OF COGNITIVE FUNCTION BETWEEN FIRST ISCHEMIC STROKE AND RECURRENT ISCHEMIC STROKE PATIENTS
by: Fildza Intan Rizkia, et al.
Published: (2021-12-01)
by: Fildza Intan Rizkia, et al.
Published: (2021-12-01)
The molecular mechanism of Xiaoxuming decoction in the treatment of ischemic stroke based on network pharmacology and molecular docking
by: Xiang Li, et al.
Published: (2023-06-01)
by: Xiang Li, et al.
Published: (2023-06-01)
Fecal metabolites as early-phase biomarkers and prediction panel for ischemic stroke
by: Ke Xu, et al.
Published: (2025-08-01)
by: Ke Xu, et al.
Published: (2025-08-01)
Comparison of the Predictive Value of Inflammatory Biomarkers for the Risk of Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
by: Li J, et al.
Published: (2023-09-01)
by: Li J, et al.
Published: (2023-09-01)
Roles for circulating polyunsaturated fatty acids in ischemic stroke and modifiable factors: a Mendelian randomization study
by: Tonghui Yuan, et al.
Published: (2020-07-01)
by: Tonghui Yuan, et al.
Published: (2020-07-01)
Selective Biomarkers of Oxidative Stress in Ischemic Stroke
by: Hanna Pawluk, et al.
Published: (2022-11-01)
by: Hanna Pawluk, et al.
Published: (2022-11-01)
Comparing the risk of subsequent ischemic stroke and mortality in patients with epilepsy and patients with ischemic stroke
by: Po-Yu Lin, et al.
Published: (2025-06-01)
by: Po-Yu Lin, et al.
Published: (2025-06-01)
Sirtuins: Promising Therapeutic Targets to Treat Ischemic Stroke
by: Yue Liu, et al.
Published: (2023-08-01)
by: Yue Liu, et al.
Published: (2023-08-01)
Polymorphism in genes encoding two fatty acid binding proteins increases risk of ischemic stroke in a Chinese Han population
by: Maolin Cao, et al.
Published: (2023-04-01)
by: Maolin Cao, et al.
Published: (2023-04-01)
Discovery of metabolic biomarkers for distinguishing LAA and SVO subtypes of acute ischemic stroke
by: Yan Yu, et al.
Published: (2025-07-01)
by: Yan Yu, et al.
Published: (2025-07-01)
Experience with therapeutic hypothermia in the treatment of ischemic stroke
by: I E Kalenova, et al.
Published: (2012-06-01)
by: I E Kalenova, et al.
Published: (2012-06-01)
Historical diagnostic and therapeutic changes of ischemic stroke based on the highly cited articles
by: Yerim Kim, et al.
Published: (2020-08-01)
by: Yerim Kim, et al.
Published: (2020-08-01)
One-Month Mortality in Patients with Ischemic Stroke Using Score for Early Ischemic Stroke Mortality
by: Maeda Jabeen, et al.
Published: (2024-08-01)
by: Maeda Jabeen, et al.
Published: (2024-08-01)
Molecular mechanisms and therapeutic strategies for ferroptosis and cuproptosis in ischemic stroke
by: Jing Wang, et al.
Published: (2024-10-01)
by: Jing Wang, et al.
Published: (2024-10-01)
Impact of remnant cholesterol on acute ischemic stroke prognosis: a nationwide cohort analysis stratified by non-alcoholic fatty liver disease status
by: Sili Jiang, et al.
Published: (2025-01-01)
by: Sili Jiang, et al.
Published: (2025-01-01)
Adult Stroke Screening Tool in Childhood Ischemic Stroke
by: Kathleen M. Gorman, et al.
Published: (2017-01-01)
by: Kathleen M. Gorman, et al.
Published: (2017-01-01)
Pathogenesis and Biomarkers of Cancer-Related Ischemic Stroke
by: Cen G, et al.
Published: (2024-11-01)
by: Cen G, et al.
Published: (2024-11-01)
PREDICTABLE BIOMARKERS IN ACUTE CEREBRAL ISCHEMIC STROKE
by: Eliza Cetean, et al.
Published: (2019-12-01)
by: Eliza Cetean, et al.
Published: (2019-12-01)
Models of Ischemic Stroke (Review)
by: A. M. Golubev
Published: (2020-03-01)
by: A. M. Golubev
Published: (2020-03-01)
Drug-induced ischemic stroke
by: T. M. Ostroumova, et al.
Published: (2021-09-01)
by: T. M. Ostroumova, et al.
Published: (2021-09-01)
Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy
by: Xueyang Shen, et al.
Published: (2023-04-01)
by: Xueyang Shen, et al.
Published: (2023-04-01)
Integrative Multi-Omics Analysis for Etiology Classification and Biomarker Discovery in Stroke: Advancing towards Precision Medicine
by: Alberto Labarga, et al.
Published: (2024-05-01)
by: Alberto Labarga, et al.
Published: (2024-05-01)
Does nonalcoholic fatty liver disease predispose patients to carotid arteriosclerosis and ischemic stroke?
by: Qian Jin, et al.
Published: (2022-07-01)
by: Qian Jin, et al.
Published: (2022-07-01)
Therapeutic and preventive effects of astaxanthin in ischemic stroke
by: Xu Wang, et al.
Published: (2024-09-01)
by: Xu Wang, et al.
Published: (2024-09-01)
Ischemic Stroke and TIA in Young Adults
by: J Gordon Millichap
Published: (2013-02-01)
by: J Gordon Millichap
Published: (2013-02-01)
Copeptin as biomarker for acute ischemic stroke prognosis and revascularization treatment efficacy
by: Antonia Ioana Vasile, et al.
Published: (2024-12-01)
by: Antonia Ioana Vasile, et al.
Published: (2024-12-01)
Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach
by: Nanding Li, et al.
Published: (2025-07-01)
by: Nanding Li, et al.
Published: (2025-07-01)
Long non-coding RNAs as biomarkers and therapeutic targets for ischemic stroke
by: Galina Sufianova, et al.
Published: (2022-12-01)
by: Galina Sufianova, et al.
Published: (2022-12-01)
Analysis of the Potential Mechanism of Sanhua Decoction in Treating Ischemic Stroke Based on Network Pharmacology and Molecular Docking Technology
by: Wei Zhao, et al.
Published: (2024-12-01)
by: Wei Zhao, et al.
Published: (2024-12-01)
Evaluation of Recurrence of Ischemic Stroke and Transient Ischemic Attack Three Months After the First Transient Ischemic Attack Based On Diffusion-Weighted Imaging (DWI)
by: Abolfazl Atalu, et al.
Published: (2023-04-01)
by: Abolfazl Atalu, et al.
Published: (2023-04-01)
Plasma homocysteine concentrationand MTHFR C677T polymorphism are related to ischemic stroke
by: ZHANG Yuchao, XIE Mingzhang, ZHAO Mengmeng, ZHOU Xiaochun, YANG Chenyan, LIU Yanxuan
Published: (2025-03-01)
by: ZHANG Yuchao, XIE Mingzhang, ZHAO Mengmeng, ZHOU Xiaochun, YANG Chenyan, LIU Yanxuan
Published: (2025-03-01)
Identification of disulfidptosis-related genes and analysis of immune infiltration characteristics in ischemic strokes
by: Rongxing Qin, et al.
Published: (2023-10-01)
by: Rongxing Qin, et al.
Published: (2023-10-01)
Similar Items
-
Multi-Omics and Experimental Validation Identify GPX7 and Glutathione-Associated Oxidative Stress as Potential Biomarkers in Ischemic Stroke
by: Tianzhi Li, et al.
Published: (2025-05-01) -
Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms
by: Fangyuan Cheng, et al.
Published: (2025-09-01) -
The role of inflammation in Ischemic stroke: from biomarker to treatment
by: Liangyi Xiao, et al.
Published: (2025-09-01) -
Integrating machine learning and multi-omics analysis to reveal nucleotide metabolism-related immune genes and their functional validation in ischemic stroke
by: Tianzhi Li, et al.
Published: (2025-03-01) -
Integrative Analysis of Machine Learning and Molecule Docking Simulations for Ischemic Stroke Diagnosis and Therapy
by: Jingwei Song, et al.
Published: (2023-11-01)
