Pharmacological Evaluation of Novel Hydrazide and Hydrazone Derivatives: Anti-Inflammatory and Analgesic Potential in Preclinical Models
Hydrazones, characterized by their C=N–NH functional group, are promising candidates in medicinal chemistry due to their ability to interact with biological targets. This study evaluated the anti-inflammatory and analgesic properties of <i>N</i>-pyrrolylcarbohydrazide (<b>1</b&g...
| Published in: | Molecules |
|---|---|
| Main Authors: | Hristina Zlatanova-Tenisheva, Stanislava Vladimirova |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-03-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/7/1472 |
Similar Items
Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent
by: Hristina Zlatanova, et al.
Published: (2019-04-01)
by: Hristina Zlatanova, et al.
Published: (2019-04-01)
Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
by: Omeed Muhsin Hassan, et al.
Published: (2019-06-01)
by: Omeed Muhsin Hassan, et al.
Published: (2019-06-01)
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid
by: Zlatanova Hristina, et al.
Published: (2018-06-01)
by: Zlatanova Hristina, et al.
Published: (2018-06-01)
Synthesis and biological study of novel FELL analogs containing L- or d-tyr instead of l-phe in the N-terminus
by: Boryana Borisova, et al.
Published: (2025-01-01)
by: Boryana Borisova, et al.
Published: (2025-01-01)
A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone
by: Abu Syed Md. Mosaddek, et al.
Published: (2008-06-01)
by: Abu Syed Md. Mosaddek, et al.
Published: (2008-06-01)
Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen
by: Mahmoud A. El Hassab, et al.
Published: (2025-07-01)
by: Mahmoud A. El Hassab, et al.
Published: (2025-07-01)
Correction: Formulation of zein nanoparticles for augmenting the anti-inflammatory activity of dexketoprofen
by: Mahmoud A. El Hassab, et al.
Published: (2025-08-01)
by: Mahmoud A. El Hassab, et al.
Published: (2025-08-01)
Anti-inflammatory activity of Magic Spice Fruits of Sumac (Rhus coriaria L)
by: Saya Mohammed, et al.
Published: (2022-12-01)
by: Saya Mohammed, et al.
Published: (2022-12-01)
Anti-inflammatory, Analgesic, and Gastric Tissue Effects of Lacidipine, Aspirin, and Their Combination
by: Bahar Isik, et al.
Published: (2023-11-01)
by: Bahar Isik, et al.
Published: (2023-11-01)
Analgesic and anti-inflammatory evaluations of S-naproxen derivatives in animals models supported by molecular docking simulation studies
by: Naveed Muhammad, et al.
Published: (2025-09-01)
by: Naveed Muhammad, et al.
Published: (2025-09-01)
Effects of Non-Thermal Plasma on the Transition from Nano-Crystalline to Amorphous Structure in Water and Subsequent Effects on Viscosity
by: Joshua Ginzburg, et al.
Published: (2023-12-01)
by: Joshua Ginzburg, et al.
Published: (2023-12-01)
Identification and quantification of oleanane triterpenoid saponins and potential analgesic and anti-inflammatory activities from the roots and rhizomes of Panax stipuleanatus
by: Pan-Pan Shu, et al.
Published: (2021-03-01)
by: Pan-Pan Shu, et al.
Published: (2021-03-01)
Anti-inflammatory and anti-nociceptive effects of Cinnamon and Clove essential oils nanogels: an in vivo study
by: Fariba Esmaeili, et al.
Published: (2022-05-01)
by: Fariba Esmaeili, et al.
Published: (2022-05-01)
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF HERTIA INTERMEDIA LEAF EXTRACT IN RATS
by: Razieh Amini Zadeh, et al.
Published: (2025-03-01)
by: Razieh Amini Zadeh, et al.
Published: (2025-03-01)
The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation
by: Aziz TA, et al.
Published: (2020-07-01)
by: Aziz TA, et al.
Published: (2020-07-01)
Evaluation of Analgesics and Anti-Inflammatory Activity of the Root Extract of Impatiens rothii (Balsaminaceae) in Rodents
by: Ashagrie G, et al.
Published: (2023-04-01)
by: Ashagrie G, et al.
Published: (2023-04-01)
Anti-inflammatory activity of bark of Xeromphis spinosa
by: Biswa Nath Das, et al.
Published: (2009-06-01)
by: Biswa Nath Das, et al.
Published: (2009-06-01)
Tarantula cubensis extract (Theranekron®) ınhibits ınflammation in carrageenan-ınduced acute paw edema in rats
by: E.C. Ozfırat, et al.
Published: (2022-04-01)
by: E.C. Ozfırat, et al.
Published: (2022-04-01)
Crocin alleviates the local paw edema induced by histamine in rats
by: Esmaeal Tamaddonfard, et al.
Published: (2012-03-01)
by: Esmaeal Tamaddonfard, et al.
Published: (2012-03-01)
Determination of Antiplasmodial and Antityphoid Activity of Extract from Guava, Paw-Paw and Mango Leaves
by: Auwal Shitu' and Muhammad Ibrahim Usman’*
Published: (2024-03-01)
by: Auwal Shitu' and Muhammad Ibrahim Usman’*
Published: (2024-03-01)
Evaluation of Anti-Inflammatory Activity of the Methanol Extracts of Premna schimperi Engl (Lamiaceae) Leaves in Rats
by: Arega M, et al.
Published: (2023-11-01)
by: Arega M, et al.
Published: (2023-11-01)
Evaluation of the analgesic effect of teucrium polium extract in mice
by: M.R Heidari, et al.
Published: (1999-03-01)
by: M.R Heidari, et al.
Published: (1999-03-01)
Involvement of TNFα, IL-1β, COX-2 and NO in the anti-inflammatory activity of Tamarix aphylla in Wistar albino rats: an in-vivo and in-vitro study
by: Nada Fayez, et al.
Published: (2024-01-01)
by: Nada Fayez, et al.
Published: (2024-01-01)
Anti-inflammatory activity of Indonesian polyherbal product containing Curcuma zanthorrhiza and Vitex trifolia as the main ingredients in carrageenan- and histamine-induced inflammation in Wistar rats
by: Zullies Ikawati, et al.
Published: (2022-12-01)
by: Zullies Ikawati, et al.
Published: (2022-12-01)
Design, Synthesis and Preliminary Pharmacological Evaluation of New Non-Steroidal Anti-Inflammatory Agents Having a 4-(Methylsulfonyl) Aniline Pharmacophore
by: Akeel Abdul Kadhum Jassim, et al.
Published: (2012-02-01)
by: Akeel Abdul Kadhum Jassim, et al.
Published: (2012-02-01)
Anti-nociceptive and Anti-inflammatory Activities of Asparacosin A Involve Selective Cyclooxygenase 2 and Inflammatory Cytokines Inhibition: An in-vitro, in-vivo, and in-silico Approach
by: Nasiara Karim, et al.
Published: (2019-03-01)
by: Nasiara Karim, et al.
Published: (2019-03-01)
Investigating the anti-inflammatory and analgesic properties of leaves ethanolic extracts of Cedrus libani and Pinus brutia
by: Lina Karrat, et al.
Published: (2022-04-01)
by: Lina Karrat, et al.
Published: (2022-04-01)
Leaves extract of Murraya Koenigii linn for anti--inflammatory and analgesic activity in animal models
by: Shailly Gupta, et al.
Published: (2010-01-01)
by: Shailly Gupta, et al.
Published: (2010-01-01)
The effects of radio-frequency radiation (RFR) exposure on the analgesic efficacy of morphine in healthy rats and rats with inflammation
by: Paweł Bodera, et al.
Published: (2019-07-01)
by: Paweł Bodera, et al.
Published: (2019-07-01)
Alcoholic extracts of Teucrium polium exhibit remarkable anti-inflammatory activity: In vivo study
by: Hamda A. Al-Naemi, et al.
Published: (2024-01-01)
by: Hamda A. Al-Naemi, et al.
Published: (2024-01-01)
Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation
by: Ioana Boarescu, et al.
Published: (2021-12-01)
by: Ioana Boarescu, et al.
Published: (2021-12-01)
Design, Synthesis and Preliminary Pharmacological Evaluation of Mutual Prodrug of Non-Steroidal Anti-Inflammatory Drugs Coupling With Natural Anti-Oxidants Via Glycine
by: Monther Faisal Mahdi, et al.
Published: (2013-06-01)
by: Monther Faisal Mahdi, et al.
Published: (2013-06-01)
Rumex nervosus nanoparticles versus aqueous extract: introduction of novel immunomodulatory anti-inflammatory nano-preparation for management of paw oedema and gastritis in rats
by: Bassant M. M. Ibrahim, et al.
Published: (2024-01-01)
by: Bassant M. M. Ibrahim, et al.
Published: (2024-01-01)
From Chemistry to Pharmacology: Exploring the Anti-Inflammatory and Antioxidant Potential of Novel Dexketoprofen Amide Derivatives
by: Marko Karović, et al.
Published: (2025-06-01)
by: Marko Karović, et al.
Published: (2025-06-01)
Effects of Combined Shinbaro and Celecoxib in a Complete Freund’s Adjuvant-Induced Inflammatory Pain Mouse Model
by: Jang JH, et al.
Published: (2025-02-01)
by: Jang JH, et al.
Published: (2025-02-01)
Synthesis and Investigation of Anti-Inflammatory Activity of New Thiourea Derivatives of Naproxen
by: Nikola Nedeljković, et al.
Published: (2023-04-01)
by: Nikola Nedeljković, et al.
Published: (2023-04-01)
Targeting Nrf2 and NF-κB Signaling Pathways in Inflammatory Pain: The Role of Polyphenols from Thinned Apples
by: Livia Interdonato, et al.
Published: (2023-07-01)
by: Livia Interdonato, et al.
Published: (2023-07-01)
The nature and impact of antidepressant withdrawal symptoms and proposal of the Discriminatory Antidepressant Withdrawal Symptoms Scale (DAWSS)
by: Joanna Moncrieff, et al.
Published: (2024-04-01)
by: Joanna Moncrieff, et al.
Published: (2024-04-01)
Synthesis, Characterization, and Investigation of Anti-Inflammatory and Cytotoxic Activities of Novel Thiourea Derivatives of Naproxen
by: Nikola Nedeljković, et al.
Published: (2023-12-01)
by: Nikola Nedeljković, et al.
Published: (2023-12-01)
Cashew (<i>Anacardium occidentale</i> L.) Nuts Counteract Oxidative Stress and Inflammation in an Acute Experimental Model of Carrageenan-Induced Paw Edema
by: Marika Cordaro, et al.
Published: (2020-07-01)
by: Marika Cordaro, et al.
Published: (2020-07-01)
Similar Items
-
Biological Screening of Novel Structural Analog of Celecoxib as Potential Anti-Inflammatory and Analgesic Agent
by: Hristina Zlatanova, et al.
Published: (2019-04-01) -
Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
by: Omeed Muhsin Hassan, et al.
Published: (2019-06-01) -
In Vivo Evaluation of Anti-inflammatory Activity of 2-[3-Acetyl- 5-(4-chloro-phenyl)-2-methyl-pyrrol-1-yl]-4-methylsulfanylbutyric Acid
by: Zlatanova Hristina, et al.
Published: (2018-06-01) -
Synthesis and biological study of novel FELL analogs containing L- or d-tyr instead of l-phe in the N-terminus
by: Boryana Borisova, et al.
Published: (2025-01-01) -
A comparative study of the anti-inflammatory effect of aqueous extract of neem leaf and dexamethasone
by: Abu Syed Md. Mosaddek, et al.
Published: (2008-06-01)
