Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications
The limited regenerative capacity of the human body, in conjunction with a shortage of healthy autologous tissue, has created an urgent need for alternative grafting materials. A potential solution is a tissue-engineered graft, a construct which supports and integrates with host tissue. One of the k...
| Published in: | Biomimetics |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2313-7673/8/2/205 |
| _version_ | 1849901225339781120 |
|---|---|
| author | Andrew Johnston Anthony Callanan |
| author_facet | Andrew Johnston Anthony Callanan |
| author_sort | Andrew Johnston |
| collection | DOAJ |
| container_title | Biomimetics |
| description | The limited regenerative capacity of the human body, in conjunction with a shortage of healthy autologous tissue, has created an urgent need for alternative grafting materials. A potential solution is a tissue-engineered graft, a construct which supports and integrates with host tissue. One of the key challenges in fabricating a tissue-engineered graft is achieving mechanical compatibility with the graft site; a disparity in these properties can shape the behaviour of the surrounding native tissue, contributing to the likelihood of graft failure. The purpose of this review is to examine the means by which researchers have altered the mechanical properties of tissue-engineered constructs via hybrid material usage, multi-layer scaffold designs, and surface modifications. A subset of these studies which has investigated the function of their constructs in vivo is also presented, followed by an examination of various tissue-engineered designs which have been clinically translated. |
| format | Article |
| id | doaj-art-756c7deb9f41498bbf892de37e7c052d |
| institution | Directory of Open Access Journals |
| issn | 2313-7673 |
| language | English |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-756c7deb9f41498bbf892de37e7c052d2025-08-20T00:59:20ZengMDPI AGBiomimetics2313-76732023-05-018220510.3390/biomimetics8020205Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical ApplicationsAndrew Johnston0Anthony Callanan1Institute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh EH9 3DW, UKInstitute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh EH9 3DW, UKThe limited regenerative capacity of the human body, in conjunction with a shortage of healthy autologous tissue, has created an urgent need for alternative grafting materials. A potential solution is a tissue-engineered graft, a construct which supports and integrates with host tissue. One of the key challenges in fabricating a tissue-engineered graft is achieving mechanical compatibility with the graft site; a disparity in these properties can shape the behaviour of the surrounding native tissue, contributing to the likelihood of graft failure. The purpose of this review is to examine the means by which researchers have altered the mechanical properties of tissue-engineered constructs via hybrid material usage, multi-layer scaffold designs, and surface modifications. A subset of these studies which has investigated the function of their constructs in vivo is also presented, followed by an examination of various tissue-engineered designs which have been clinically translated.https://www.mdpi.com/2313-7673/8/2/205scaffoldbiomimetictissue engineering3D printingelectrospinning |
| spellingShingle | Andrew Johnston Anthony Callanan Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications scaffold biomimetic tissue engineering 3D printing electrospinning |
| title | Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications |
| title_full | Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications |
| title_fullStr | Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications |
| title_full_unstemmed | Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications |
| title_short | Recent Methods for Modifying Mechanical Properties of Tissue-Engineered Scaffolds for Clinical Applications |
| title_sort | recent methods for modifying mechanical properties of tissue engineered scaffolds for clinical applications |
| topic | scaffold biomimetic tissue engineering 3D printing electrospinning |
| url | https://www.mdpi.com/2313-7673/8/2/205 |
| work_keys_str_mv | AT andrewjohnston recentmethodsformodifyingmechanicalpropertiesoftissueengineeredscaffoldsforclinicalapplications AT anthonycallanan recentmethodsformodifyingmechanicalpropertiesoftissueengineeredscaffoldsforclinicalapplications |