The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer
ABSTRACT Background MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M‐MDSCs) and polymorphonuclear MDSCs (PMN‐MDSCs). Recent Findings They are significant components of the tumor microenvironment (TME). Besides, recent studies also verifie...
| 出版年: | Cancer Reports |
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| 主要な著者: | , , , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Wiley
2025-02-01
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| 主題: | |
| オンライン･アクセス: | https://doi.org/10.1002/cnr2.70044 |
| _version_ | 1849498014054350848 |
|---|---|
| author | Chengyuan Li Yucheng Xue Eloy Yinwang Zhaoming Ye |
| author_facet | Chengyuan Li Yucheng Xue Eloy Yinwang Zhaoming Ye |
| author_sort | Chengyuan Li |
| collection | DOAJ |
| container_title | Cancer Reports |
| description | ABSTRACT Background MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M‐MDSCs) and polymorphonuclear MDSCs (PMN‐MDSCs). Recent Findings They are significant components of the tumor microenvironment (TME). Besides, recent studies also verified that MDSCs also facilitated the progression of bone metastasis by regulating the network of cytokines and the function of immune cells. Conclusion It is necessary to summarize the mechanisms of MDSC recruitment and immunosuppression, and their impact on bone metastasis. |
| format | Article |
| id | doaj-art-7586e914017e4bcda73b615a0cd1dbd3 |
| institution | Directory of Open Access Journals |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| spelling | doaj-art-7586e914017e4bcda73b615a0cd1dbd32025-08-20T03:04:53ZengWileyCancer Reports2573-83482025-02-0182n/an/a10.1002/cnr2.70044The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic CancerChengyuan Li0Yucheng Xue1Eloy Yinwang2Zhaoming Ye3Department of Orthopedic Surgery, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaDepartment of Orthopedic Surgery, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou ChinaABSTRACT Background MDSCs are immature neutrophils and monocytes with immunosuppressive potentials, involving mononuclear MDSCs (M‐MDSCs) and polymorphonuclear MDSCs (PMN‐MDSCs). Recent Findings They are significant components of the tumor microenvironment (TME). Besides, recent studies also verified that MDSCs also facilitated the progression of bone metastasis by regulating the network of cytokines and the function of immune cells. Conclusion It is necessary to summarize the mechanisms of MDSC recruitment and immunosuppression, and their impact on bone metastasis.https://doi.org/10.1002/cnr2.70044bone metastasisimmune suppressionmyeloid‐derived suppressor cells |
| spellingShingle | Chengyuan Li Yucheng Xue Eloy Yinwang Zhaoming Ye The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer bone metastasis immune suppression myeloid‐derived suppressor cells |
| title | The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer |
| title_full | The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer |
| title_fullStr | The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer |
| title_full_unstemmed | The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer |
| title_short | The Recruitment and Immune Suppression Mechanisms of Myeloid‐Derived Suppressor Cells and Their Impact on Bone Metastatic Cancer |
| title_sort | recruitment and immune suppression mechanisms of myeloid derived suppressor cells and their impact on bone metastatic cancer |
| topic | bone metastasis immune suppression myeloid‐derived suppressor cells |
| url | https://doi.org/10.1002/cnr2.70044 |
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