Choline Metabolism to the Proatherogenic Metabolite Trimethylamine Occurs Primarily in the Distal Colon Microbiome In Vitro

Background/Objectives: Gut microbial metabolism of choline and related quaternary amines to trimethylamine (TMA) is the first step in the production of trimethylamine N-oxide (TMAO), a circulating metabolite that contributes to the development of atherosclerosis and other forms of cardiovascular dis...

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Bibliographic Details

Published in:	Metabolites
Main Authors:	Anthony M. Buckley, Sarah Zaidan, Michael G. Sweet, Duncan J. Ewin, Juanita G. Ratliff, Aliyah Alkazemi, William Davis Birch, Ashley M. McAmis, Andrew P. Neilson
Format:	Article
Language:	English
Published:	MDPI AG 2025-08-01
Subjects:	gut microbiome choline trimethylamine trimethylamine N-oxide <i>cutC</i> TMA lyase
Online Access:	https://www.mdpi.com/2218-1989/15/8/552