HSP70 promotes MLKL polymerization and necroptosis
Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70...
| الحاوية / القاعدة: | Molecular & Cellular Oncology |
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| المؤلفون الرئيسيون: | , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
Taylor & Francis Group
2020-09-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | http://dx.doi.org/10.1080/23723556.2020.1791561 |
| الملخص: | Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis. |
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| تدمد: | 2372-3556 |