Kunxian capsule alleviates podocyte injury and proteinuria by inactivating β-catenin in db/db mice

BackgroundDiabetic kidney disease (DKD) remains the primary cause of end-stage renal disease (ESRD) globally, but treatment options are limited. Kunxian capsule (KXC) has been utilized for the treatment of autoimmune diseases and IgA nephropathy in China. However, its effect on DKD remains poorly in...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Frontiers in Medicine
المؤلفون الرئيسيون:	Bo Jin, Jing Liu, Yan Zhu, Jian Lu, Qingyan Zhang, Yan Liang, Qiuyuan Shao, Chunming Jiang
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2023-06-01
الموضوعات:	Kunxian capsule diabetic kidney disease podocyte β-Catenin epithelial-to-mesenchymal transition
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fmed.2023.1213191/full

مواد مشابهة

Clinical study, network pharmacology, and molecular docking of Kunxian capsule in treating idiopathic membranous nephropathy
حسب: Jia Lv, وآخرون
منشور في: (2025-02-01)

Efficacy and safety of Kunxian in IgA nephropathy
حسب: Yang Yang, وآخرون
منشور في: (2025-03-01)

Long noncoding RNA MEG3 suppresses podocyte injury in diabetic nephropathy by inactivating Wnt/β-catenin signaling
حسب: Xiajing Che, وآخرون
منشور في: (2019-11-01)

Panax Notoginseng Ameliorates Podocyte EMT by Targeting the Wnt/β-Catenin Signaling Pathway in STZ-Induced Diabetic Rats
حسب: Xie L, وآخرون
منشور في: (2020-02-01)

Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin
حسب: Mohammed Alquraishi, وآخرون
منشور في: (2022-05-01)

Zuogui Wan ameliorates high glucose-induced podocyte apoptosis and improves diabetic nephropathy in db/db mice
حسب: Bingbing Zhu, وآخرون
منشور في: (2022-11-01)

Nuclear Receptor Interacting Protein-2 Mediates the Stabilization and Activation of β-Catenin During Podocyte Injury
حسب: Qing Hou, وآخرون
منشور في: (2021-12-01)

Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice
حسب: Xiaoya Li, وآخرون
منشور في: (2023-10-01)

GSK-3β and Vitamin D Receptor are Involved in β-Catenin and Snail Signaling in High Glucose-Induced Epithelial-Mesenchymal Transition of Mouse Podocytes
حسب: Jia Guo, وآخرون
منشور في: (2014-04-01)

Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling
حسب: Eike Schwartze, وآخرون
منشور في: (2025-06-01)

Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pathway
حسب: Yanmo Cai, وآخرون
منشور في: (2025-09-01)

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury
حسب: Chunhong Wang, وآخرون
منشور في: (2022-01-01)

Podocytes and Proteinuria in ANCA-Associated Glomerulonephritis: A Case-Control Study
حسب: Emma E. van Daalen, وآخرون
منشور في: (2019-06-01)

Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
حسب: Le Gong, وآخرون
منشور في: (2023-12-01)

The recruitment mechanisms and potential therapeutic targets of podocytes from parietal epithelial cells
حسب: Lihua Ni, وآخرون
منشور في: (2021-10-01)

suPAR and WT1 modify the adhesion of podocytes and are related to proteinuria in class IV lupus nephritis
حسب: Juan-José Bollain-y-Goytia, وآخرون
منشور في: (2023-12-01)

Podocyte Pathology and Nephropathy
حسب: Sandra eMerscher, وآخرون
منشور في: (2014-07-01)

PODOCYTES… WHATS UNDER YOURS? (PODOCYTES AND FOOT PROCESSES AND HOW THEY CHANGE IN NEPHROPATHY)
حسب: Chris Robert Neal
منشور في: (2015-02-01)

Podocyte epithelial-mesenchymal transdifferentiation and glomerular disease
حسب: CHEN Hai-yun, وآخرون
منشور في: (2020-01-01)

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus
حسب: Ram K Menon, وآخرون
منشور في: (2014-09-01)

Metformin Protects against Podocyte Injury in Diabetic Kidney Disease
حسب: Sanna Lehtonen
منشور في: (2020-12-01)

Quantifying Podocyte Number in a Small Sample Size of Glomeruli with CUBIC to Evaluate Podocyte Depletion of db/db Mice
حسب: Jiaoyu Shi, وآخرون
منشور في: (2023-01-01)

Sanqi Qushi Granule Alleviates Proteinuria and Podocyte Damage in NS Rat: A Network Pharmacology Study and in vivo Experimental Validation
حسب: Wang L, وآخرون
منشور في: (2023-06-01)

Ginkgolide B alleviates renal and podocyte injury in membranous nephropathy by inhibiting ferroptosis
حسب: Daoyuan Lv, وآخرون
منشور في: (2025-09-01)

Sulforaphane alleviates membranous nephropathy by inhibiting oxidative stress-associated podocyte pyroptosis
حسب: Daoyuan Lv, وآخرون
منشور في: (2025-02-01)

Huaiqihuang may protect from proteinuria by resisting MPC5 podocyte damage via targeting p-ERK/CHOP pathway
حسب: Tingxia Li, وآخرون
منشور في: (2016-08-01)

The research progress of podocytes in crescentic glomerulonephritis
حسب: ZOU Rong, وآخرون
منشور في: (2020-01-01)

Effect of N-acetyl-seryl-aspartyl-lysyl-proline on high glucose-induced podocyte injury
حسب: ZHA Dong-qing, وآخرون
منشور في: (2018-01-01)

Salidroside alleviates ferroptosis of retinal ganglion cells in db/db mice
حسب: Wenqiang Liu, وآخرون
منشور في: (2025-06-01)

Modified Huangqi Chifeng Decoction Attenuates Proteinuria by Reducing Podocyte Injury in a Rat Model of Immunoglobulin a Nephropathy
حسب: Meiying Chang, وآخرون
منشور في: (2021-07-01)

Modulation of podocyte autophagy and migration by advanced glycationend products through Wnt/β-catenin signaling pathway
حسب: ZHANG Li, وآخرون
منشور في: (2018-01-01)

New insights into the immune functions of podocytes: the role of complement
حسب: Valentina Bruno, وآخرون
منشور في: (2023-04-01)

Pharmacological Blockade of the Adenosine A<sub>2B</sub> Receptor Is Protective of Proteinuria in Diabetic Rats, through Affecting Focal Adhesion Kinase Activation and the Adhesion Dynamics of Podocytes
حسب: Pablo Mendoza-Soto, وآخرون
منشور في: (2024-05-01)

Nonimmunologic targets of immunosuppressive agents in podocytes
حسب: Tae-Hyun Yoo, وآخرون
منشور في: (2015-06-01)

Protective Role of Tangshen Formula on the Progression of Renal Damage in db/db Mice by TRPC6/Talin1 Pathway in Podocytes
حسب: Qian Wang, وآخرون
منشور في: (2020-01-01)

Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
حسب: Li Lin, وآخرون
منشور في: (2023-11-01)

Genes and podocytes – new insights and perspectives on mechanisms of podocytopathy
حسب: Agnieszka eBierzynska, وآخرون
منشور في: (2015-01-01)

Fyn‐binding protein ADAP supports actin organization in podocytes
حسب: Zhenzhen Wu, وآخرون
منشور في: (2017-12-01)

Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
حسب: Xueling Li, وآخرون
منشور في: (2020-02-01)

Extracellular Vesicles From High Glucose-Treated Podocytes Induce Apoptosis of Proximal Tubular Epithelial Cells
حسب: Ying Huang, وآخرون
منشور في: (2020-11-01)