A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein
Combined therapies are usually used to treat <i>acne vulgaris</i> since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-lactoglobulin as a double payloa...
| Published in: | Antibiotics |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Online Access: | https://www.mdpi.com/2079-6382/11/2/282 |
| _version_ | 1851850152766078976 |
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| author | Beatriz Rodríguez-Amigo Cormac Hally Núria Roig-Yanovsky Pietro Delcanale Stefania Abbruzzetti Montserrat Agut Cristiano Viappiani Santi Nonell |
| author_facet | Beatriz Rodríguez-Amigo Cormac Hally Núria Roig-Yanovsky Pietro Delcanale Stefania Abbruzzetti Montserrat Agut Cristiano Viappiani Santi Nonell |
| author_sort | Beatriz Rodríguez-Amigo |
| collection | DOAJ |
| container_title | Antibiotics |
| description | Combined therapies are usually used to treat <i>acne vulgaris</i> since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-lactoglobulin as a double payload carrier of hypericin (an antimicrobial photodynamic agent) and all-<i>trans</i> retinoic acid (an anti-inflammatory drug) for <i>S. aureus</i> in vitro photodynamic inactivation. The addition of all-<i>trans</i> retinoic acid to hypericin-β-lactoglobulin complex renders a photochemically safe vehicle due to the photophysical quenching of hypericin, which recovers its photodynamic activity when in contact with bacteria. The ability of hypericin to photoinactivate <i>S. aureus</i> was not affected by retinoic acid. β-Lactoglobulin is a novel biocompatible and photochemically safe nanovehicle with strong potential for the treatment of acne. |
| format | Article |
| id | doaj-art-7b00a97e6693401e9be944259ebe3a0c |
| institution | Directory of Open Access Journals |
| issn | 2079-6382 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-7b00a97e6693401e9be944259ebe3a0c2025-08-19T22:24:54ZengMDPI AGAntibiotics2079-63822022-02-0111228210.3390/antibiotics11020282A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin ProteinBeatriz Rodríguez-Amigo0Cormac Hally1Núria Roig-Yanovsky2Pietro Delcanale3Stefania Abbruzzetti4Montserrat Agut5Cristiano Viappiani6Santi Nonell7Institut Quimic de Sarrià, Universitat Ramon Llull, 08017 Barcelona, SpainInstitut Quimic de Sarrià, Universitat Ramon Llull, 08017 Barcelona, SpainInstitut Quimic de Sarrià, Universitat Ramon Llull, 08017 Barcelona, SpainDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università di Parma, 43124 Parma, ItalyDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università di Parma, 43124 Parma, ItalyInstitut Quimic de Sarrià, Universitat Ramon Llull, 08017 Barcelona, SpainDipartimento di Scienze Matematiche, Fisiche e Informatiche, Università di Parma, 43124 Parma, ItalyInstitut Quimic de Sarrià, Universitat Ramon Llull, 08017 Barcelona, SpainCombined therapies are usually used to treat <i>acne vulgaris</i> since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-lactoglobulin as a double payload carrier of hypericin (an antimicrobial photodynamic agent) and all-<i>trans</i> retinoic acid (an anti-inflammatory drug) for <i>S. aureus</i> in vitro photodynamic inactivation. The addition of all-<i>trans</i> retinoic acid to hypericin-β-lactoglobulin complex renders a photochemically safe vehicle due to the photophysical quenching of hypericin, which recovers its photodynamic activity when in contact with bacteria. The ability of hypericin to photoinactivate <i>S. aureus</i> was not affected by retinoic acid. β-Lactoglobulin is a novel biocompatible and photochemically safe nanovehicle with strong potential for the treatment of acne.https://www.mdpi.com/2079-6382/11/2/282acne vulgarisretinoic acidhypericinβ-lactoglobulinphotodynamic therapy |
| spellingShingle | Beatriz Rodríguez-Amigo Cormac Hally Núria Roig-Yanovsky Pietro Delcanale Stefania Abbruzzetti Montserrat Agut Cristiano Viappiani Santi Nonell A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein acne vulgaris retinoic acid hypericin β-lactoglobulin photodynamic therapy |
| title | A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein |
| title_full | A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein |
| title_fullStr | A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein |
| title_full_unstemmed | A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein |
| title_short | A Double Payload Complex between Hypericin and All-<em>trans</em> Retinoic Acid in the β-Lactoglobulin Protein |
| title_sort | double payload complex between hypericin and all em trans em retinoic acid in the β lactoglobulin protein |
| topic | acne vulgaris retinoic acid hypericin β-lactoglobulin photodynamic therapy |
| url | https://www.mdpi.com/2079-6382/11/2/282 |
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