Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance

IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Anc...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Shanshan Liang, Wei Xu, Peiying Zhong, Chuanmin Tao, Li Zhang, Chengyao Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Subjects:
IgG4-RD-related ophthalmopathy
diagnostic criteria
M protein
IgE
monoclonal gammaglobulinemia of undetermined significance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565388/full
Description
Summary:IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.
ISSN:1664-3224

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