The effect of salidroside in promoting endogenous neural regeneration after cerebral ischemia/reperfusion involves notch signaling pathway and neurotrophic factors

Abstract Background Salidroside is the major bioactive and pharmacological active substance in Rhodiola rosea L. It has been reported to have neuroprotective effects on cerebral ischemia/reperfusion (I/R). However, whether salidroside can enhance neural regeneration after cerebral I/R is still unkno...

Full description

Bibliographic Details
Published in:	BMC Complementary Medicine and Therapies
Main Authors:	Jiabing Zheng, Jizhou Zhang, Jing Han, Zhichang Zhao, Kan Lin
Format:	Article
Language:	English
Published:	BMC 2024-08-01
Subjects:	Salidroside Cerebral ischemia/reperfusion Ischemic stroke Neural regeneration Notch signaling pathway BDNF
Online Access:	https://doi.org/10.1186/s12906-024-04597-w

Similar Items

Study of Salidroside on Expression of Synaptophysin and Tau in Rats after Local Cerebral Ischemia-reperfusion Injury
by: Yanqing SU, et al.
Published: (2017-12-01)

Prevention of salidroside pre-treatment against ischemia-reperfusion injury in rats after kidney transplantation
by: ZHANG Peng-jie, et al.
Published: (2019-01-01)

Salidroside pretreatment attenuates apoptosis and autophagy during hepatic ischemia–reperfusion injury by inhibiting the mitogen-activated protein kinase pathway in mice
by: Feng J, et al.
Published: (2017-07-01)

Integrative analysis of transcriptomics and metabolomics reveals the protective effect and mechanism of salidroside on testicular ischemia-reperfusion injury
by: Ya Ping Jiang, et al.
Published: (2024-05-01)

Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch/ITGB1 signal path in CSVD Model
by: Tu Zhilan, et al.
Published: (2025-02-01)

Therapeutic potential and molecular mechanisms of salidroside in ischemic diseases
by: Jingxuan Han, et al.
Published: (2022-08-01)

Preactivation of Notch1 in remote ischemic preconditioning reduces cerebral ischemia-reperfusion injury through crosstalk with the NF-κB pathway
by: Weidong Liang, et al.
Published: (2019-09-01)

β-caryophyllene improves cerebral ischemia reperfusion injury in rats via Notch1/NF-κB signal axis
by: LIU Jingdong, et al.
Published: (2021-02-01)

Electroacupuncture at Quchi and Zusanli Enhances the Proliferation of Cortex and SVZ-derived Neural Stem Cell in Cerebral Ischemia-Reperfusion Injured Rats Via Activation of Notch1 Signaling Pathway
by: Jing TAO, et al.
Published: (2015-10-01)

Salidroside ameliorates cerebral ischemic injury and regulates the glutamate metabolism pathway in astrocytes
by: Xiaoyu Zheng, et al.
Published: (2024-11-01)

Understudied targets of the ischemia-reperfusion injury pathogenesis in liver transplantation
by: P. O. Svishcheva, et al.
Published: (2024-06-01)

毛柳苷在脑缺血再灌注后抑制神经元自噬及神经保护作用研究 Neuroprotective Effect and Mechanism of Salidroside in Cerebral Ischemia-reperfusion Injury in Mouse Model
by: 温少红，刘宽，赵顺英，董雯，陈青芳，陈文涛，叶维贞，姜鸣钰，刘向荣
Published: (2022-09-01)

Blockade of the Notch1/Jagged1 pathway in Kupffer cells aggravates ischemia-reperfusion injury of orthotopic liver transplantation in mice
by: He Bai, et al.
Published: (2019-05-01)

Remote ischemic preconditioning plays a neuroprotective role in cerebral ischemia-reperfusion mice by inhibiting mitophagy
by: Jiayi Zhu, et al.
Published: (2024-10-01)

Ischemic Tolerance—A Way to Reduce the Extent of Ischemia–Reperfusion Damage
by: Rastislav Burda, et al.
Published: (2023-03-01)

Establishment of Ischemia-Reperfusion Model in Cynomolgus Macaques and Effects of Edaravone Intervention
by: PAN Mengxian, et al.
Published: (2023-04-01)

Oxidative Post-translational Protein Modifications upon Ischemia/Reperfusion Injury
by: Aleksandra Binek, et al.
Published: (2024-01-01)

Protective Effects of Ischemic Preconditioning Protocols on Ischemia-Reperfusion Injury in Rat Liver
by: Jie Lin, et al.
Published: (2020-10-01)

Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury
by: Yugang Ma, et al.
Published: (2025-03-01)

Metabolic and Microcirculatory Changes in Severe Renal Ischemia–Reperfusion and Ischemic Preconditioning in the Rat: Are They Detectable in the First Hour of Reperfusion?
by: David Martin Adorjan, et al.
Published: (2025-04-01)

Platelet Contributions to Myocardial Ischemia/Reperfusion Injury
by: Nancy Schanze, et al.
Published: (2019-06-01)

Hexafluoroisopropanol decreases liver ischemia–reperfusion injury by downregulation of high mobility group box‐1 protein
by: Agustin Vintimilla Moscoso, et al.
Published: (2022-12-01)

Neuroprotective Effects of Pregabalin on Cerebral Ischemia and Reperfusion
by: Sanem Aşçı, et al.
Published: (2016-04-01)

Protective Effect of Ischemic Postconditioning against Ischemia Reperfusion-Induced Myocardium Oxidative Injury in IR Rats
by: Jiangwei Ma, et al.
Published: (2012-03-01)

Salidroside attenuates oxygen and glucose deprivation-induced neuronal injury by inhibiting ferroptosis
by: Ying-Zhi Li, et al.
Published: (2023-01-01)

Systematic review of melatonin in cerebral ischemia-reperfusion injury: critical role and therapeutic opportunities
by: Chenguang Zhang, et al.
Published: (2024-02-01)

An Approach to Characterizing the Complicated Sequential Metabolism of Salidroside in Rats
by: Zhiqiang Luo, et al.
Published: (2016-05-01)

Notch1 Protects against Ischemic-Reperfusion Injury by Suppressing PTEN-Pink1-Mediated Mitochondrial Dysfunction and Mitophagy
by: Qirong Xu, et al.
Published: (2022-12-01)

Preclinical anti-apoptotic properties of salidroside for hypoxic-ischemic cerebral damage: a systematic review and meta-analysis
by: Wang Xiaobo, et al.
Published: (2023-06-01)

Antihypothyroid Effect of Salidroside
by: Nazym K. Korbozova, et al.
Published: (2022-11-01)

ProBDNF Upregulation in Murine Hind Limb Ischemia Reperfusion Injury: A Driver of Inflammation
by: Katherine Aby, et al.
Published: (2023-06-01)

Research progress on protective effect of polysaccharide from traditional Chinese medicine on myocardial ischemia-reperfusion injury
by: Qian Sun, et al.
Published: (2025-01-01)

Ischemic pre and postconditioning in skeletal muscle injury produced by ischemia and reperfusion in rats
by: José Alves Lintz, et al.
Published: (2013-06-01)

Dynamic mechanisms and targeted interventions in cerebral ischemia–reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies
by: Xufeng Meng, et al.
Published: (2025-08-01)

Postconditioning attenuates acute intestinal ischemia–reperfusion injury
by: Ilker Sengul, et al.
Published: (2013-03-01)

Preconditioned MSCs Alleviate Cerebral Ischemia-Reperfusion Injury in Rats by Improving the Neurological Function and the Inhibition of Apoptosis
by: Jin Zheng, et al.
Published: (2022-05-01)

The Role of the JAK-STAT Signaling Pathway in the Protective Effects of Hepatic Ischemia Post-conditioning Against the Injury Induced by Ischemia/Reperfusion in the Rat Liver
by: Neda Ghasemi Pour Afshar, et al.
Published: (2024-03-01)

Improvement of polydopamine-loaded salidroside on osseointegration of titanium implants
by: Qingqing Yi, et al.
Published: (2022-02-01)

The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury
by: Jirapong Vongsfak, et al.
Published: (2021-08-01)

THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia–reperfusion injury by inducing ferroptosis in endothelial cells
by: Chang Liu, et al.
Published: (2025-02-01)