An active peptide from yak inhibits hypoxia-induced lung injury via suppressing VEGF/MAPK/inflammatory signaling

Pulmonary vascular remodeling and inflammation play an important role in the hypoxic-induced lung diseases. Our previous investigations showed that peptide from yak milk residues could alleviate inflammation. In this study, our results suggest that peptide (LV) from yak milk residues peptide had pro...

Full description

Bibliographic Details
Published in:	Redox Biology
Main Authors:	Feiyan Yang, Zeyu He, Zhongxing Chu, Wen Li, Guangfan Qu, Han Lu, Yiping Tang, Shuguo Sun, Zhang Luo, Feijun Luo
Format:	Article
Language:	English
Published:	Elsevier 2024-09-01
Subjects:	Peptide Pulmonary vascular remodeling Hypoxia Transcriptome Metabolome Lung injury
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231724002301

Similar Items

A novel peptide from yak ameliorates hypoxia-induced cardiac dysfunction via targeting gut microbiota and HIF-1α pathway
by: Feiyan Yang, et al.
Published: (2025-08-01)

Integrated lipidomics and microbiomics reveal the quality changes of fresh yak tenderloin during storage
by: Feiyan Yang, et al.
Published: (2024-12-01)

Chronic hypoxia is associated with transcriptomic reprogramming and increased genomic instability in cancer cells
by: Raefa Abou Khouzam, et al.
Published: (2023-03-01)

Subacute Hypoxia Induces Cardiac Remodeling and Mitochondrial Dysfunction via Apoptotic Pathways in a Rabbit Model of Tracheal Stenosis
by: Taeyun Kim, et al.
Published: (2025-09-01)

Protein of yak milk residue: Structure, functionality, and the effects on the quality of non-fat yogurt
by: Guangfan Qu, et al.
Published: (2024-06-01)

Neonatal exposure to hypoxia induces early arterial stiffening via activation of lysyl oxidases
by: Jochen Steppan, et al.
Published: (2023-04-01)

Left ventricular remodeling in normotensive Wistar rats exposed to intermittent hypoxia of different duration
by: Yu. M. Kolesnyk, et al.
Published: (2023-04-01)

The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy
by: Rui MA, et al.
Published: (2025-04-01)

Integrative analysis identifies potential ferroptosis-related genes of hypoxia adaptation in yak
by: Jian Zhang, et al.
Published: (2022-10-01)

Metabolic Plasticity and Transcriptomic Reprogramming Orchestrate Hypoxia Adaptation in Yak
by: Ci Huang, et al.
Published: (2025-07-01)

Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxia
by: Matthew W. Gorr, et al.
Published: (2020-01-01)

Altered hypoxia-induced cellular responses and inflammatory profile in lung fibroblasts from COPD patients compared to control subjects
by: Ryde Martin, et al.
Published: (2024-07-01)

How hypoxia affects microbiota metabolism in mice
by: Ainiwaer Ailizire, et al.
Published: (2023-09-01)

Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells
by: Cho Eui Jin, et al.
Published: (2019-12-01)

Novel hypoxia-induced HIF-1αactivation in asthma pathogenesis
by: Mengzhi Wan, et al.
Published: (2024-07-01)

THBS1 mediates hypoxia driven EndMT in pulmonary hypertension
by: Bingming Peng, et al.
Published: (2024-10-01)

Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation
by: Juan Carlos Alarcon Barrera, et al.
Published: (2023-07-01)

Hypoxia Attenuates Pressure Overload‐Induced Heart Failure
by: Natali Froese, et al.
Published: (2024-02-01)

A global view on quantitative proteomic and metabolic analysis of rat livers under different hypoxia protocols
by: Jin Xu, et al.
Published: (2024-10-01)

Metabolomics and transcriptomics of embryonic livers reveal hypoxia adaptation of Tibetan chickens
by: Mingming Xue, et al.
Published: (2024-02-01)

Hypoxia and EGF Stimulation Regulate VEGF Expression in Human Glioblastoma Multiforme (GBM) Cells by Differential Regulation of the PI3K/Rho-GTPase and MAPK Pathways
by: Samer Nicolas, et al.
Published: (2019-11-01)

Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway
by: Xuefeng Bai, et al.
Published: (2025-04-01)

Hypoxia Activates FGF-23-ERK/MAPK Signaling Pathway in Ischemia-Reperfusion-Induced Acute Kidney Injury
by: Weihua Liu, et al.
Published: (2024-10-01)

Acute hypoxia modulate macrophage phenotype accompanied with transcriptome re-programming and metabolic re-modeling
by: Binda Sun, et al.
Published: (2025-02-01)

Research on the Mechanism of Hypoxia Tolerance of a Hybrid Fish Using Transcriptomics and Metabolomics
by: Yuhua Tang, et al.
Published: (2025-10-01)

Hypometabolic Responses to Chronic Hypoxia: A Potential Role for Membrane Lipids
by: Elie Farhat, et al.
Published: (2021-07-01)

Single cell transcriptomic analyses reveal diverse and dynamic changes of distinct populations of lung interstitial macrophages in hypoxia-induced pulmonary hypertension
by: Sushil Kumar, et al.
Published: (2024-04-01)

Histological, microecological and transcriptomic physiological responses underlying hypoxia and reoxygenation adaptation in yellowtail kingfish (Seriola lalandi)
by: Heting Zhou, et al.
Published: (2023-03-01)

Metabolomics analysis to characterize the effects of flavonoids on tobacco seedlings under cold and hypoxia stress
by: Longxi Li, et al.
Published: (2025-12-01)

The hypoxia adaptation strategy of the big-belly seahorses (Hippocampus abdominalis) with tuft gills
by: Long-Wu Jia, et al.
Published: (2025-03-01)

Short‐term intermittent hypoxia induces simultaneous systemic insulin resistance and higher cardiac contractility in lean mice
by: Maximin Détrait, et al.
Published: (2021-03-01)

Biophysical interplay between extracellular matrix remodeling and hypoxia signaling in regulating cancer metastasis
by: Sun-Ah Lee, et al.
Published: (2024-03-01)

Association Between Intermittent Hypoxia and Left Ventricular Remodeling in Patients With Obstructive Sleep Apnea-Hypopnea Syndrome
by: Ming Deng, et al.
Published: (2021-02-01)

Characterization of lipid composition and nutritional quality of yak ghee at different altitudes: A quantitative lipidomic analysis
by: Feiyan Yang, et al.
Published: (2024-03-01)

Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak (Bos grunniens)
by: Xiao-yun WU, et al.
Published: (2015-04-01)

N-VEGF, the Autoregulatory Arm of VEGF-A
by: Marina Katsman, et al.
Published: (2022-04-01)

Influence of Intermittent Hypoxia/Hypercapnia on Atherosclerosis, Gut Microbiome, and Metabolome
by: Jin Xue, et al.
Published: (2021-04-01)

Mild Hypoxia Enhances the Expression of HIF and VEGF and Triggers the Response to Injury in Rat Kidneys
by: Yaya Xu, et al.
Published: (2021-06-01)

Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling
by: Jiaxin Hu, et al.
Published: (2023-08-01)

Metabolomic and flux‐balance analysis of age‐related decline of hypoxia tolerance in Drosophila muscle tissue
by: Laurence Coquin, et al.
Published: (2008-12-01)