HECT, UBA and WWE domain containing 1 represses cholesterol efflux during CD4+ T cell activation in Sjögren’s syndrome

Introduction: Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by exocrine gland dysfunction, leading to loss of salivary function. Histological analysis of salivary glands from SS patients reveals a high infiltration of immune cells, particularly activated CD4+ T cells. Thus,...

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Bibliographic Details
Published in:Frontiers in Pharmacology
Main Authors: Junhao Yin, Jiabao Xu, Changyu Chen, Xinyi Ma, Hanyi Zhu, Lisong Xie, Baoli Wang, Yanxiong Shao, Yijie Zhao, Yu Wei, Anni Hu, Zhanglong Zheng, Chuangqi Yu, Jiayao Fu, Lingyan Zheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Subjects:
CD4+ T cell
HUWE1
ABCA1
Sjögren’s syndrome
cholesterol efflux
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1191692/full

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