Trajectory of GFR Decline and Fluctuation in Albuminuria Leading to End-Stage Kidney Disease in Patients With Biopsy-Confirmed Diabetic Kidney Disease

• Published in: Kidney International Reports
• Main Authors: Masayuki Yamanouchi, Naoki Sawa, Tadashi Toyama, Miho Shimizu, Megumi Oshima, Yusuke Yoshimura, Hisashi Sugimoto, Shigekazu Kurihara, Yuki Oba, Daisuke Ikuma, Hiroki Mizuno, Akinari Sekine, Tatsuya Suwabe, Junichi Hoshino, Yoshifumi Ubara, Shigeko Hara, Kengo Furuichi, Takashi Wada
• Format: Article
• Language: English
• Published: Elsevier 2024-02-01
• Subjects: diabetic kidney disease; glomerular filtration rate; albuminuria; end-stage kidney disease; trajectory of eGFR; fluctuation in albuminuria
• Online Access: http://www.sciencedirect.com/science/article/pii/S2468024923015802

Introduction: Data on longitudinal trajectory of kidney function decline and fluctuation in albuminuria leading to end-stage kidney disease (ESKD) is sparse in patients with type 2 diabetes. Methods: Using data from an observational study of patients with type 2 diabetes and biopsy-confirmed diabetic kidney disease (DKD), generalized additive mixed models (GAMMs) were performed to quantify patterns of longitudinal trajectory of estimated glomerular filtration rate (eGFR) decline to ESKD associated with repeated measures of urine albumin-to-creatinine ratio (ACR). Results: Over a median follow-up period of 3.3 years, 155 of 319 patients progressed to ESKD. Among these patients, 91.6% exhibited a curvilinear pattern in their eGFR trajectory. The median coefficient of variation for ACR, representing the variability in ACR measurements, was 48.9 (interquartile range: 36.9, 68.2). The median compound annual growth rate (CAGR) for ACR, reflecting the variation in ACR progression over time, was 43.6% (interquartile range: 0.0, 102.5); and 84.5% of patients developed nephrotic-range albuminuria, with a majority remaining nephrotic and subsequently progressing to ESKD. There was a positive association between the instantaneous speed of eGFR decline and ACR. Conclusion: The observed curvilinear pattern in eGFR trajectory, high variability in ACR progression over time, and positive correlation between the speed of eGFR decline and ACR highlight the complex dynamics of disease progression and emphasize close monitoring of ACR fluctuation over time in patients with DKD.