Robustness during Aging—Molecular Biological and Physiological Aspects
Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field...
| Published in: | Cells |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-08-01
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| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/8/1862 |
| _version_ | 1850401389132382208 |
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| author | Emanuel Barth Patricia Sieber Heiko Stark Stefan Schuster |
| author_facet | Emanuel Barth Patricia Sieber Heiko Stark Stefan Schuster |
| author_sort | Emanuel Barth |
| collection | DOAJ |
| container_title | Cells |
| description | Understanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution. |
| format | Article |
| id | doaj-art-7e3dc8a630dc4aa9959f606a3dbf37ea |
| institution | Directory of Open Access Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| spelling | doaj-art-7e3dc8a630dc4aa9959f606a3dbf37ea2025-08-19T22:50:07ZengMDPI AGCells2073-44092020-08-0198186210.3390/cells9081862Robustness during Aging—Molecular Biological and Physiological AspectsEmanuel Barth0Patricia Sieber1Heiko Stark2Stefan Schuster3RNA Bioinformatics/High Throughput Analysis, Faculty of Mathematics and Computer Science, Friedrich Schiller University Jena, 07743 Jena, GermanyMatthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, GermanyInstitute of Zoology and Evolutionary Research with Phyletic Museum, Friedrich Schiller University Jena, 07743 Jena, GermanyMatthias Schleiden Institute, Bioinformatics, Friedrich Schiller University Jena, 07743 Jena, GermanyUnderstanding the process of aging is still an important challenge to enable healthy aging and to prevent age-related diseases. Most studies in age research investigate the decline in organ functionality and gene activity with age. The focus on decline can even be considered a paradigm in that field. However, there are certain aspects that remain surprisingly stable and keep the organism robust. Here, we present and discuss various properties of robust behavior during human and animal aging, including physiological and molecular biological features, such as the hematocrit, body temperature, immunity against infectious diseases and others. We examine, in the context of robustness, the different theories of how aging occurs. We regard the role of aging in the light of evolution.https://www.mdpi.com/2073-4409/9/8/1862age-related diseasesfailure accumulationhealthy agingimmunosenescencerobustnesstheories of aging |
| spellingShingle | Emanuel Barth Patricia Sieber Heiko Stark Stefan Schuster Robustness during Aging—Molecular Biological and Physiological Aspects age-related diseases failure accumulation healthy aging immunosenescence robustness theories of aging |
| title | Robustness during Aging—Molecular Biological and Physiological Aspects |
| title_full | Robustness during Aging—Molecular Biological and Physiological Aspects |
| title_fullStr | Robustness during Aging—Molecular Biological and Physiological Aspects |
| title_full_unstemmed | Robustness during Aging—Molecular Biological and Physiological Aspects |
| title_short | Robustness during Aging—Molecular Biological and Physiological Aspects |
| title_sort | robustness during aging molecular biological and physiological aspects |
| topic | age-related diseases failure accumulation healthy aging immunosenescence robustness theories of aging |
| url | https://www.mdpi.com/2073-4409/9/8/1862 |
| work_keys_str_mv | AT emanuelbarth robustnessduringagingmolecularbiologicalandphysiologicalaspects AT patriciasieber robustnessduringagingmolecularbiologicalandphysiologicalaspects AT heikostark robustnessduringagingmolecularbiologicalandphysiologicalaspects AT stefanschuster robustnessduringagingmolecularbiologicalandphysiologicalaspects |