ER–Mitochondria Microdomains in Cardiac Ischemia–Reperfusion Injury: A Fresh Perspective

The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the maintenance of an array of physiological processes. The physical contact and association between ER and mitochondria, known as the ER–mitochondria microdomains or mitochondria-associated ER membrane (MAM), temporally and...

Full description

Bibliographic Details
Published in:	Frontiers in Physiology
Main Authors:	Hao Zhou, Shuyi Wang, Shunying Hu, Yundai Chen, Jun Ren
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-06-01
Subjects:	ER–mitochondria microdomains ischemia/reperfusion injury mitochondrial fission mitophagy oxidative stress calcium signaling
Online Access:	https://www.frontiersin.org/article/10.3389/fphys.2018.00755/full

Similar Items

Mitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury
by: Andrew R. Kulek, et al.
Published: (2020-01-01)

The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury
by: Jirapong Vongsfak, et al.
Published: (2021-08-01)

Editorial: Disparate roles of mitochondria in cell survival and cell death: new insight from the CNS
by: Raghu R. Krishnamoorthy
Published: (2023-11-01)

Ripk3 induces mitochondrial apoptosis via inhibition of FUNDC1 mitophagy in cardiac IR injury
by: Hao Zhou, et al.
Published: (2017-10-01)

NbSOBIR1 Partitions Into Plasma Membrane Microdomains and Binds ER-Localized NbRLP1
by: Yi-Hua Li, et al.
Published: (2021-09-01)

Perspectives on mitochondrial relevance in cardiac ischemia/reperfusion injury
by: Gaia Pedriali, et al.
Published: (2022-12-01)

Mitochondrial Quality Control in the Heart: The Balance between Physiological and Pathological Stress
by: Giovanni Fajardo, et al.
Published: (2022-06-01)

Ras-related protein Rab-20 inhibition alleviates cerebral ischemia/reperfusion injury by inhibiting mitochondrial fission and dysfunction
by: Jia Guo, et al.
Published: (2022-10-01)

The structure and function of mitochondria-associated endoplasmic reticulum membranes and their role in pancreatic β-cells dysregulation
by: Olena Kaniuka, et al.
Published: (2023-12-01)

Microdomain forming proteins in oncogenesis
by: I. B. Zborovskaya, et al.
Published: (2016-09-01)

Role of Mitochondria–ER Contact Sites in Mitophagy
by: Alina Rühmkorf, et al.
Published: (2023-07-01)

Sphingolipids and Mitochondrial Dynamic
by: Lais Brigliadori Fugio, et al.
Published: (2020-03-01)

Shaping of Hepatic Ischemia/Reperfusion Events: The Crucial Role of Mitochondria
by: João S. Teodoro, et al.
Published: (2022-02-01)

Interorganellar Membrane Microdomains: Dynamic Platforms in the Control of Calcium Signaling and Apoptosis
by: Alessandra d'Azzo, et al.
Published: (2013-08-01)

Advances in the Study of Mitophagy in Renal Ischemia–Reperfusion Injury
by: Rumeng Li, et al.
Published: (2025-04-01)

Mitochondria-Associated ER Membranes – The Origin Site of Autophagy
by: Ming Yang, et al.
Published: (2020-07-01)

Arabidopsis mutants in sphingolipid synthesis as tools to understand the structure and function of membrane microdomains in plasmodesmata
by: ARIADNA eGONZÁLEZ-SOLÍS, et al.
Published: (2014-01-01)

Fluorescent probes for the visualization of membrane microdomain, deformation, and fusion
by: Pei‐Hong Tong, et al.
Published: (2025-03-01)

Changes in Drp1 Function and Mitochondrial Morphology Are Associated with the α-Synuclein Pathology in a Transgenic Mouse Model of Parkinson’s Disease
by: Philipp Portz, et al.
Published: (2021-04-01)

The Multifunctional Sorting Protein PACS-2 Controls Mitophagosome Formation in Human Vascular Smooth Muscle Cells through Mitochondria-ER Contact Sites
by: Manon Moulis, et al.
Published: (2019-06-01)

Bioinformatics integration reveals key genes associated with mitophagy in myocardial ischemia-reperfusion injury
by: Zhian Chen, et al.
Published: (2024-03-01)

Meldonium, as a potential neuroprotective agent, promotes neuronal survival by protecting mitochondria in cerebral ischemia–reperfusion injury
by: Weijie Yang, et al.
Published: (2024-08-01)

Ischemia time impacts on respiratory chain functions and Ca2+-handling of cardiac subsarcolemmal mitochondria subjected to ischemia reperfusion injury
by: Marcus Leistner, et al.
Published: (2019-05-01)

Membrane Associated RNA‐Containing Vesicles Regulate Cortical Astrocytic Microdomain Calcium Transients in Awake Ischemic Stroke Mice
by: Zhongqiu Zhou, et al.
Published: (2024-12-01)

Mitochondria associated ER membranes and cerebral ischemia: Molecular mechanisms and therapeutic strategies
by: Rui-Qi Jiang, et al.
Published: (2023-05-01)

Isolated Mitochondria State after Myocardial Ischemia-Reperfusion Injury and Cardioprotection: Analysis by Flow Cytometry
by: Claire Crola Da Silva, et al.
Published: (2023-03-01)

Increased oxidative stress caused by impaired mitophagy aggravated liver ischemia and reperfusion injury in diabetic mice
by: Kong Zhijun, et al.
Published: (2023-01-01)

The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
by: Andrey V. Kuznetsov, et al.
Published: (2019-10-01)

Plant Sterol Clustering Correlates with Membrane Microdomains as Revealed by Optical and Computational Microscopy
by: Ling Tang, et al.
Published: (2021-09-01)

Mitophagy in hepatic ischemia-reperfusion injury
by: ZHANG Xiangxin, LI Wen
Published: (2024-06-01)

Mechanisms Associated with Mitophagy and Ferroptosis in Cerebral Ischemia-reperfusion Injury
by: Yugang Ma, et al.
Published: (2025-03-01)

Glycolipids: Linchpins in the Organization and Function of Membrane Microdomains
by: Kei Hanafusa, et al.
Published: (2020-10-01)

USP5-induced deubiquitination of P4HB alleviates ER stress-mediated apoptosis in intestinal ischemia/reperfusion
by: Shili Ning, et al.
Published: (2025-06-01)

Vitexin enhances mitophagy and improves renal ischemia-reperfusion injury by regulating the p38/MAPK pathway
by: Jianan Chen, et al.
Published: (2025-12-01)

Rapamycin Enhances Mitophagy and Attenuates Apoptosis After Spinal Ischemia-Reperfusion Injury
by: Qiang Li, et al.
Published: (2018-12-01)

Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer’s disease
by: Yujie Lyu, et al.
Published: (2024-08-01)

Remote ischemic preconditioning plays a neuroprotective role in cerebral ischemia-reperfusion mice by inhibiting mitophagy
by: Jiayi Zhu, et al.
Published: (2024-10-01)

Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers
by: Joseph Flores-Toro, et al.
Published: (2021-07-01)

Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
by: Viktor I. Korolchuk, et al.
Published: (2017-07-01)

The role of mitochondria-associated ER membranes in disease pathology: protein complex and therapeutic targets
by: Jin Zhang, et al.
Published: (2025-06-01)