Antihypertensive Effect of Lactoferrin on Dexamethasone-Induced Hypertension in Rat
Background: Dexamethasone-induced hypertension is one of the animal models of hypertension. Lactoferrin is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of lactoferrin was investigated on dexamethasone-induced hypertension in rat and...
| Published in: | مجله دانشکده پزشکی اصفهان |
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| Main Authors: | , |
| Format: | Article |
| Language: | Persian |
| Published: |
Isfahan University of Medical Sciences
2013-09-01
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| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/3041 |
| Summary: | Background: Dexamethasone-induced hypertension is one of the animal models of hypertension. Lactoferrin is a natural iron-binding protein with proposed antihypertensive effects. In this study, the effect of chronic use of lactoferrin was investigated on dexamethasone-induced hypertension in rat and compared with captopril.
Methods: In this experimental study, hypertension was induced by subcutaneously injection of dexamethasone (30 µg/kg/day) for 15 days in Wistar rat. Lactoferrin (300 mg/kg) and captopril (40 mg/kg) were orally given from the day 8 to 15. Systolic blood pressure was measured by tail cuff. Body weight was measured during experiment and thymus weight was detected as a marker of glucocorticoid activity at the end of study.
Findings: Administration of dexamethasone increased systolic blood pressure (115.6 + 3.3 to 150.1 + 7.4 mmHg) and decreased body and thymus weight (P < 0.05). Chronic administration of lactoferrin and captopril for one week decreased systolic blood pressure (P < 0.01 for both). Lactoferrin also prevented body weight loss.
Conclusion: The results indicated antihypertensive effect of lactoferrin on dexamethasone-induced hypertension. Further studies are suggested for finding the mechanism of lactoferrin in this model of hypertension. |
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| ISSN: | 1027-7595 1735-854X |