Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memo...

Full description

Bibliographic Details
Published in:	Nature Communications
Main Authors:	Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F. de Miranda, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Jason E. McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell, Andrew D. Weinberg
Format:	Article
Language:	English
Published:	Nature Portfolio 2018-07-01
Online Access:	https://doi.org/10.1038/s41467-018-05072-0

Similar Items

Tumor resident memory CD8 T cells and concomitant tumor immunity develop independently of CD4 help
by: Terry R. Medler, et al.
Published: (2023-04-01)

CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden
by: Sjoerd H van der Burg, et al.
Published: (2023-02-01)

IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells
by: Olivier Fesneau, et al.
Published: (2024-11-01)

Development and therapeutic manipulation of the head and neck cancer tumor environment to improve clinical outcomes
by: Thomas Duhen, et al.
Published: (2022-07-01)

1013 NKG2A expression on tumor reactive CD8 T cells is induced by IL-12
by: Thomas Duhen, et al.
Published: (2023-11-01)

High Expression of Ecto-Nucleotidases CD39 and CD73 in Human Endometrial Tumors
by: Elisabet Aliagas, et al.
Published: (2014-01-01)

Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers
by: Shahd Talhouni, et al.
Published: (2023-05-01)

385 Selection of CD8+CD103+CD31- tumor infiltrating lymphocytes (TIL) from bulk cultures enriches tumor-specific reactivity in a patient-agnostic manner
by: Steven A Rosenberg, et al.
Published: (2023-11-01)

CD103+ tumor-resident CD8+ T cell numbers underlie improved patient survival in oropharyngeal squamous cell carcinoma
by: Jean Yang, et al.
Published: (2020-05-01)

CD69+CD103+CD8+ tissue-resident memory T cells possess stronger anti-tumor activity and predict better prognosis in colorectal cancer
by: Zi-Xin Wu, et al.
Published: (2024-12-01)

CD103 in the development of experimental asthma
by: Blanchet Marie-Renee, et al.
Published: (2010-11-01)

CD39hi identifies an exhausted tumor-reactive CD8+ T cell population associated with tumor progression in human gastric cancer
by: Yang Shen, et al.
Published: (2024-04-01)

CD49b, CD87, and CD95 Are Markers for Activated Cancer-Associated Fibroblasts Whereas CD39 Marks Quiescent Normal Fibroblasts in Murine Tumor Models
by: David J. Agorku, et al.
Published: (2019-08-01)

CD103+CD8+ TRM Cells Accumulate in Tumors of Anti-PD-1-Responder Lung Cancer Patients and Are Tumor-Reactive Lymphocytes Enriched with Tc17
by: Stéphanie Corgnac, et al.
Published: (2020-10-01)

Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer
by: Qin Fang, et al.
Published: (2025-01-01)

Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population
by: Dimitris Stellas, et al.
Published: (2023-05-01)

The CD39/CD73/Adenosine and NAD/CD38/CD203a/CD73 Axis in Cutaneous T-Cell Lymphomas
by: Liyun Lin, et al.
Published: (2025-02-01)

TGF-β: Many Paths to CD103<sup>+</sup> CD8 T Cell Residency
by: Zhijuan Qiu, et al.
Published: (2021-04-01)

CD39+ conventional CD4+ T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade
by: Sabrina N. Bossio, et al.
Published: (2023-12-01)

PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells
by: Camille-Charlotte Balança, et al.
Published: (2021-01-01)

TGF-β and IL-12 conversely orchestrate the formation of CD103+ CD8 tumor-resident memory T cells to regulate response to therapeutic cancer vaccine
by: Stéphanie Corgnac, et al.
Published: (2025-08-01)

Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8+CD69+CD103+ TRM cells
by: Yimei Lai, et al.
Published: (2024-12-01)

Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice
by: Yi Zhao, et al.
Published: (2019-11-01)

Exploring CD39 and CD73 Expression as Potential Biomarkers in Prostate Cancer
by: Carla Fernanda Furtado Gardani, et al.
Published: (2023-11-01)

CD39/CD73/A2AR pathway and cancer immunotherapy
by: Chenglai Xia, et al.
Published: (2023-03-01)

The ectonucleotidases CD39 and CD73 on T cells: The new pillar of hematological malignancy
by: Xuan Jiang, et al.
Published: (2023-01-01)

Expansion of CD103+CD69+CD8+ cytotoxic liver tissue resident memory T cells and inflammatory monocytes in advanced biliary atresia
by: Freya Sibbertsen, et al.
Published: (2025-06-01)

Eribulin mesylate exerts antitumor effects via CD103
by: Kazumasa Oya, et al.
Published: (2023-12-01)

Current perspectives and trends of CD39-CD73-eAdo/A2aR research in tumor microenvironment: a bibliometric analysis
by: Tian Huang, et al.
Published: (2024-08-01)

Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET
by: Xiaoyu Fan, et al.
Published: (2023-11-01)

Assessment of CD4<sup>+</sup> cells subpopulations with the expressing CD39 and CD73 ectonucleotidases in children with psoriasis
by: D. G. Kuptsova, et al.
Published: (2022-07-01)

787 AB598, a CD39 inhibitory antibody, promotes immune-mediated tumor control
by: Christine Bowman, et al.
Published: (2023-11-01)

Identification of clinically relevant subsets CD39+PD-1+CD8+ T cells and CD39+ regulatory T cells in intrahepatic cholangiocarcinoma using single-cell CyTOF
by: Qi-Wei Zhang, et al.
Published: (2024-06-01)

CD103 Promotes the Pro-inflammatory Response of Gastric Resident CD4+ T Cell in Helicobacter pylori-Positive Gastritis
by: Peiyu Chen, et al.
Published: (2020-08-01)

Blocking the CD39/CD73 pathway synergizes with anti-CD20 bispecific antibody in nodal B-cell lymphoma
by: Carsten Müller-Tidow, et al.
Published: (2025-01-01)

Research progress of CD39-CD73-adenosine pathway in immune regulation of hepatocellular carcinoma
by: Lin SUN, et al.
Published: (2024-12-01)

The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice
by: Peng Rui-Qing, et al.
Published: (2005-01-01)

CD3 and CD20 Expressions and Infiltrating Patterns in Salivary Gland Tumors
by: Rukhsar R. Hussein, et al.
Published: (2024-05-01)

CD103+CD8+ tissue‐resident memory T lymphocytes of melanoma boost anti‐tumour immunity and predict immunotherapy outcomes
by: Tianyi Zhang, et al.
Published: (2025-09-01)

CD103–CD8+ T cells promote neurotoxic inflammation in Alzheimer’s disease via granzyme K–PAR-1 signaling
by: Eleonora Terrabuio, et al.
Published: (2025-09-01)