| Summary: | The goal of the research was to measure protein / creatinine in urine in dogs infested with D. immitis without associated change of urea and creatinine content in blood. Analysis of the ratio was called for in order to find an early indicator of nephron damage because some researches show immunemediated glomerulonephritis evolved in some dogs with dirofilariosis. A comparative analysis of the ratio was carried out in autumn and winter and in spring and summer periods for three groups of German shepherd dogs: Group 1 - control, Group 2 - with asymptomatic disease, and Group 3 - with moderately severe dirofilariosis. The research showed that urinal protein / creatinine ratio correlated with dirofilariosis severity, and may as such appear an objective index of the disease.
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