Targeting Indoleamine Dioxygenase and Tryptophan Dioxygenase in Cancer Immunotherapy: Clinical Progress and Challenges

Xuerun Peng,1,&ast; Zhipeng Zhao,1,&ast; Liwen Liu,2 Lan Bai,1 Rongsheng Tong,1 Hao Yang,3 Lei Zhong1 1Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technolo...

Full description

Bibliographic Details
Published in:	Drug Design, Development and Therapy
Main Authors:	Peng X, Zhao Z, Liu L, Bai L, Tong R, Yang H, Zhong L
Format:	Article
Language:	English
Published:	Dove Medical Press 2022-08-01
Subjects:	indoleamine 2 3-dioxygenase tryptophan-2 tryptophan metabolism cancer immunotherapy immune tolerance
Online Access:	https://www.dovepress.com/targeting-indoleamine-dioxygenase-and-tryptophan-dioxygenase-in-cancer-peer-reviewed-fulltext-article-DDDT

Similar Items

TRYPTOPHAN AND INDOLEAMINE-2,3-DIOXYGENASE (IDO) IN PATHOGENESIS OF IMMUNOSUPPRESSIVE CLINICAL CONDITIONS
by: V. A. Kozlov, et al.
Published: (2017-07-01)

The Relationships among Tryptophan, Kynurenine, Indoleamine 2,3-Dioxygenase, Depression, and Neuropsychological Performance
by: Knut A. Hestad, et al.
Published: (2017-10-01)

The 14kDa Protein Molecule Isolated from Garlic Suppresses Indoleamine 2, 3-Dioxygenase Metabolites in Mononuclear Cells In vitro
by: Nikoo Shohreh, et al.
Published: (2008-12-01)

Indoleamine-2,3-Dioxygenase as a Perioperative Marker of the Immune System
by: Corina Bello, et al.
Published: (2021-11-01)

Different Mechanisms of Catalytic Complex Formation in Two L-Tryptophan Processing Dioxygenases
by: Karin Nienhaus, et al.
Published: (2018-01-01)

Indoleamine 2,3-Dioxygenase as a Therapeutic Target for Alzheimer’s Disease and Geriatric Depression
by: Karl Savonije, et al.
Published: (2023-05-01)

The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)
by: Chiara Suvieri, et al.
Published: (2024-11-01)

Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives
by: Florent Peyraud, et al.
Published: (2022-01-01)

Targeting Indoleamine 2,3-Dioxygenase in Cancer Models Using the Novel Small Molecule Inhibitor NTRC 3883-0
by: Yvonne Grobben, et al.
Published: (2021-01-01)

Association of Indoleamine 2,3-Dioxygenase (IDO) Activity with Outcome after Cardiac Surgery in Adult Patients
by: Andrea Stieger, et al.
Published: (2024-06-01)

The Combined Use of Melatonin and an Indoleamine 2,3-Dioxygenase-1 Inhibitor Enhances Vaccine-Induced Protective Cellular Immunity to HPV16-Associated Tumors
by: Ana C. R. Moreno, et al.
Published: (2018-08-01)

The prognostic value of indoleamine 2,3-dioxygenase in colorectal cancer: a systematic review and meta-analysis
by: Tingting Yuan, et al.
Published: (2025-08-01)

Expression of the kynurenine pathway enzyme tryptophan 2,3-dioxygenase is increased in the frontal cortex of individuals with schizophrenia
by: Christine L Miller, et al.
Published: (2004-04-01)

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells
by: Marta Cecchi, et al.
Published: (2021-03-01)

Involvement of the tryptophan-kynurenine pathway in the pathogenesis of autoimmune diseases
by: A-Yuan Chen, et al.
Published: (2025-10-01)

Interleukin‐6 promotes skeletal muscle catabolism by activating tryptophan–indoleamine 2,3‐dioxygenase 1–kynurenine pathway during intra‐abdominal sepsis
by: Tingbin Xie, et al.
Published: (2023-04-01)

Local Inhibition of Indoleamine 2,3-Dioxygenase Mitigates Renal Fibrosis
by: Camilla Grønkjær Jensen, et al.
Published: (2021-07-01)

Research progress of indoleamine 2,3-dioxygenase 1 in gastric cancer
by: Pei Xiaxia, et al.
Published: (2023-03-01)

The Immunoregulatory Function of Indoleamine 2, 3 Dioxygenase and Its Application in Allotransplantation
by: Reza B. Jalili, et al.
Published: (2007-12-01)

Indoleamine-2,3-dioxygenase: An important controller in maintaining mesenchymal stem cell-mediated immunomodulatory homeostasis
by: Yufei Hui, et al.
Published: (2025-07-01)

Indoleamine 2,3-dioxygenase (IDO): Only an enzyme or a checkpoint controller?
by: Cemil Bilir, M.D., et al.
Published: (2017-07-01)

What May Constrain the Success of Indoleamine 2,3-Dioxygenase 1 Inhibitors in Cancer Immunotherapy?
by: Theodoros Eleftheriadis
Published: (2018-08-01)

Extracellular spermidine attenuates tryptophan breakdown in mitogen-stimulated peripheral human mononuclear blood cells
by: Karg Cornelia A., et al.
Published: (2025-10-01)

Single Nucleotide Polymorphisms of Indoleamine 2,3-Dioxygenase 1 Influenced the Age Onset of Parkinson's Disease
by: Nóra Török, et al.
Published: (2022-09-01)

Indoleamine 2,3- Dioxygenase: A Novel Immunotherapeutic Target for Osteosarcoma
by: Asim Farooq, et al.
Published: (2022-09-01)

Indoleamine 2,3‐dioxygenase gene expression and kynurenine to tryptophan ratio correlation with nasopharyngeal carcinoma progression and survival
by: Sameh Souissi, et al.
Published: (2022-09-01)

Indoleamine 2,3-dioxygenase expression in patients with allergic rhinitis: a case-control study
by: Luukkainen Annika, et al.
Published: (2011-12-01)

Contribution of indoleamine 2,3-dioxygenase in preeclampsia
by: Mona F.M El-Karn, et al.
Published: (2016-01-01)

Serum indoleamine 2,3-dioxygenase level and diagnostic value in patients with rosacea
by: Merve Sena Odabasi, et al.
Published: (2023-01-01)

Tryptophan-2,3-Dioxygenase as a Therapeutic Target in Digestive System Diseases
by: Zhengsen Wang, et al.
Published: (2025-03-01)

Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine/Tryptophan Pathway in the Ethanol Addiction/Withdrawal Mouse Model
by: Xi Jiang, et al.
Published: (2020-02-01)

The Potential Role of Cannabinoids in Modulating Serotonergic Signaling by Their Influence on Tryptophan Metabolism
by: Dietmar Fuchs, et al.
Published: (2010-08-01)

Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders
by: Adrian Mor, et al.
Published: (2024-07-01)

Tryptophan metabolite-regulated Treg responses contribute to attenuation of airway inflammation during specific immunotherapy in a mouse asthma model
by: Qi Hu, et al.
Published: (2020-08-01)

Pharmacological Targets of Kaempferol Within Inflammatory Pathways—A Hint Towards the Central Role of Tryptophan Metabolism
by: Stefanie Hofer, et al.
Published: (2020-02-01)

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
by: Lilla Hornyák, et al.
Published: (2018-01-01)

Indoleamine 2,3-Dioxygenase Is Involved in Interferon Gamma’s Anti-BKPyV Activity in Renal Cells
by: Tony Fiore, et al.
Published: (2020-08-01)

Regulation of the Immune Checkpoint Indoleamine 2,3-Dioxygenase Expression by Epstein–Barr Virus
by: Leila Sawada, et al.
Published: (2021-11-01)

Comprehensive behavioral analysis of indoleamine 2,3‐dioxygenase knockout mice
by: Nao Hirata, et al.
Published: (2018-09-01)

From Microbial Switches to Metabolic Sensors: Rewiring the Gut–Brain Kynurenine Circuit
by: Masaru Tanaka, et al.
Published: (2025-08-01)