Complement activation in severely ill patients with sepsis: no relationship with inflammation and disease severity

Abstract Background Sepsis is characterized by a dysregulated immune response to infection. The complement system plays an important role in the host defence to pathogens. However, exaggerated complement activation might contribute to a hyperinflammatory state. The interplay between complement activ...

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Bibliographic Details

Published in:	Critical Care
Main Authors:	Aline H. de Nooijer, Antigone Kotsaki, Eleftheria Kranidioti, Matthijs Kox, Peter Pickkers, Erik J. M. Toonen, Evangelos J. Giamarellos-Bourboulis, Mihai G. Netea
Format:	Article
Language:	English
Published:	BMC 2023-02-01
Subjects:	Sepsis Inflammation Complement Septic shock Mortality
Online Access:	https://doi.org/10.1186/s13054-023-04344-6