Ataxin-3 and its E3 partners: Implications for Machado-Joseph disease

Machado-Joseph disease (MJD) is the most common dominant inherited ataxia worldwide, caused by an unstable CAG trinucleotide expansion mutation within the SCA3 gene resulting in an expanded polyglutamine tract within the ataxin-3 protein. Ataxin-3 functions as a deubiquitinating enzyme (DUB), within...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Frontiers in Neurology
المؤلفون الرئيسيون:	Thomas M Durcan, Edward A Fon
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2013-05-01
الموضوعات:	Machado-Joseph Disease Parkinson's disease ChIP parkin Ataxin-3 Polyglutamine expansion
الوصول للمادة أونلاين:	http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00046/full

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