Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert t...
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Bibliographic Details
| Published in: | Nature Communications |
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| Main Authors: |
Nathan Riguet,
Anne-Laure Mahul-Mellier,
Niran Maharjan,
Johannes Burtscher,
Marie Croisier,
Graham Knott,
Janna Hastings,
Alice Patin,
Veronika Reiterer,
Hesso Farhan,
Sergey Nasarov,
Hilal A. Lashuel |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-11-01
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| Online Access: | https://doi.org/10.1038/s41467-021-26684-z
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