Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert t...
| Published in: | Nature Communications |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Online Access: | https://doi.org/10.1038/s41467-021-26684-z |
| _version_ | 1857130284221202432 |
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| author | Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel |
| author_facet | Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel |
| author_sort | Nathan Riguet |
| collection | DOAJ |
| container_title | Nature Communications |
| description | The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert their toxicity via different pathways. |
| format | Article |
| id | doaj-art-81663cd6def2472ea737c63e01d4fdd8 |
| institution | Directory of Open Access Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| spelling | doaj-art-81663cd6def2472ea737c63e01d4fdd82025-08-19T19:05:50ZengNature PortfolioNature Communications2041-17232021-11-0112112710.1038/s41467-021-26684-zNuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural propertiesNathan Riguet0Anne-Laure Mahul-Mellier1Niran Maharjan2Johannes Burtscher3Marie Croisier4Graham Knott5Janna Hastings6Alice Patin7Veronika Reiterer8Hesso Farhan9Sergey Nasarov10Hilal A. Lashuel11Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)BIO EM facility (BIOEM), EPFLBIO EM facility (BIOEM), EPFLLaboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Institute of Pathophysiology, Medical University of InnsbruckInstitute of Pathophysiology, Medical University of InnsbruckLaboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)Laboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL)The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that they form via distinct mechanisms and exert their toxicity via different pathways.https://doi.org/10.1038/s41467-021-26684-z |
| spellingShingle | Nathan Riguet Anne-Laure Mahul-Mellier Niran Maharjan Johannes Burtscher Marie Croisier Graham Knott Janna Hastings Alice Patin Veronika Reiterer Hesso Farhan Sergey Nasarov Hilal A. Lashuel Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title | Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title_full | Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title_fullStr | Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title_full_unstemmed | Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title_short | Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties |
| title_sort | nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition interactome and ultrastructural properties |
| url | https://doi.org/10.1038/s41467-021-26684-z |
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