Iodine mediated one-pot synthesis of 3-cyano and 3-cyano-4-methylcoumarins
2-Hydroxybenzaldehydes 1a-e on reaction with malononitrile 2 in the presence of iodine as catalyst give 3-cyanocoumarins 3a-e in one step under thermal heating as well as microwave irradiations. The latter conditions are much more efficient in terms of time (2-5 minutes) and yield as compar...
| Published in: | Journal of the Serbian Chemical Society |
|---|---|
| Main Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2014-01-01
|
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300140S.pdf |
| Summary: | 2-Hydroxybenzaldehydes 1a-e on reaction with malononitrile 2 in the presence
of iodine as catalyst give 3-cyanocoumarins 3a-e in one step under thermal
heating as well as microwave irradiations. The latter conditions are much
more efficient in terms of time (2-5 minutes) and yield as compared to
thermal conditions (2-2.5 hours). Following similar procedure,
3-cyano-4-methylcoumarins 3f-i have also been prepared by the reaction of
2-hydroxyacetophenones 1f-i with malononitrile 2. |
|---|---|
| ISSN: | 0352-5139 1820-7421 |