The expression profiling of serum miR-92a, miR-134 and miR-375 in acute ischemic stroke

Aim: To investigate the expression profile and diagnostic potentials of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients. Materials & methods: Serum miRs-92a, 134, and 375 expression profiles were estimated by qRT-PCR for 70 AIS patients, age-matched with 25 control subjects....

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Bibliographic Details
Published in:Future Science OA
Main Authors: Aya Tarek Salman, Olfat Shaker, Shereen Saeid Elshaer, Ahmed Elshafei
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Subjects:
AIS
biomarkers
miR-134
miR-375
miR-92a
miRNA
Online Access:https://www.future-science.com/doi/10.2144/fsoa-2022-0074
Description
Summary:Aim: To investigate the expression profile and diagnostic potentials of serum miR-92a, 134, and 375 in acute ischemic stroke (AIS) patients. Materials & methods: Serum miRs-92a, 134, and 375 expression profiles were estimated by qRT-PCR for 70 AIS patients, age-matched with 25 control subjects. Their diagnostic potential was estimated by ROC analysis. Results: Down-expression of miR-92a and miR-375 was found (56; 96.5%; -1.86 ± 1.36; and 53; 91.4%; -1.63 ± 1.38, respectively), while miR-134 showed a predominant upregulation (46; 79.3%; 0.853 ± 1.34). The diagnostic accuracy was the highest for miR-92a and miR-375 (area under the curve = 0.9183 and 0.898, respectively), with greater specificity for miR-375 (Sp = 96%). Conclusion: Serum miR-92a and miR-375 could be promising early detective biomarkers of AIS.
ISSN:2056-5623

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