Outcomes of Placental Abruption Depending on Severity of Pre-Eclampsia: A Multicentre Cohort Observational Retrospective Study

• Published in: Фундаментальная и клиническая медицина
• Main Authors: I. S. Rudakova, E. M. Shifman, G. P. Tikhova, M. A. Andriyakhova, N. V. Artymuk, V. A. Bagiyants, F. R. Barakaeva, S. V. Barinov, N. A. Barkovskaya, A. A. Belinina, T. E. Belokrinitskaya, R. V. Bikkuzhin, A. V. Bulavintseva, E. A. Bukharova, A. A. Bukhtin, I. G. Verveiko, V. S. Gorokhovskiy, D. E. Gurbanov, E. N. Degtyarev, K. G. Eliseeva, A. A. Ivshin, R. V. Kapustin, N. Yu. Katkova, K. A. Kargina, P. V. Kokh, A. A. Kuverin, L. V. Kuklina, A. V. Kulikov, T. Yu. Marochko, D. V. Marshalov, N. M. Milyaeva, A. A. Golovachuk, E. S. Nadezhina, S. V. Novikova, S. V. Ovechkin, A. V. Petrov, I. M. Pozdnyakov, E. G. Prodanchuk, N. Yu. Pylaeva, O. V. Riazanova, I. V. Savelyeva, A. A. Sleta, V. D. Snezhko, M. G. Tupikin, E. Yu. Upryamova, A. I. Cherny, N. V. Shindyapina, O. B. Shulman
• Format: Article
• Language: Russian
• Published: Kemerovo State Medical University 2024-06-01
• Subjects: placental abruption; pre-eclampsia; maternal outcomes; neonatal outcomes
• Online Access: https://fcm.kemsmu.ru/jour/article/view/861

Aim. Placental abruption is a severe complication of pregnancy, which is often accompanied by pre-eclampsia and early delivery. Here we aimed to study maternal and neonatal outcomes in patients with placental abruption depending on the severity of pre-eclampsia.Materials and Methods. The study included 509 patients with placental abruption and pre-eclampsia from 22 medical centers in 16 regions of the Russian Federation, which were divided into two groups: patients with placental abruption and severe pre-eclampsia (n = 369) and patients with placental abruption and moderate pre-eclampsia (n = 140).Results. Regardless of the severity of pre-eclampsia, average term of placental abruption was 34 weeks of pregnancy. Among the adverse maternal outcomes in patients with placental abruption and severe pre-eclampsia were coagulopathy (OR = 5.01; 95% CI = 1.17–21.46) and near miss proportion (OR = 2.95; 95% CI =1.22 –7.08) which were significantly more common as compared to a moderate pre-eclampsia. Neonatal outcomes were accompanied by a high perinatal mortality (12.8%) and neonatal morbidity due to a high prevalence of premature birth (65%), asphyxia (64%), and small for gestational age (40%). Groups with severe and moderate pre-eclampsia had no statistically significant differences in neonatal outcomes, excepting congenital malformations which were found less frequently (OR = 0.32; 95% CI 0.13–0.79) in severe pre-eclampsia.Conclusion. Severity of pre-eclampsia did not affect neonatal outcomes in women with placental abruption. Maternal outcomes were significantly worse in patients with severe pre-eclampsia in comparison with those with moderate pre-eclampsia.