Autologous Microfragmented Adipose Tissue Reduces the Catabolic and Fibrosis Response in an In Vitro Model of Tendon Cell Inflammation
Background. Mesenchymal stem cells (MSCs) emerged as a promising therapy for tendon pathologies. Microfragmented adipose tissue (μFAT) represents a convenient autologous product for the application of MSC-based therapies in the clinical setting. In the present study, the ability of μFAT to counterac...
| Published in: | Stem Cells International |
|---|---|
| Main Authors: | Marco Viganò, Gaia Lugano, Carlotta Perucca Orfei, Alessandra Menon, Enrico Ragni, Alessandra Colombini, Paola De Luca, Pietro Randelli, Laura de Girolamo |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Online Access: | http://dx.doi.org/10.1155/2019/5620286 |
Similar Items
Insights into Inflammatory Priming of Adipose-Derived Mesenchymal Stem Cells: Validation of Extracellular Vesicles-Embedded miRNA Reference Genes as A Crucial Step for Donor Selection
by: Enrico Ragni, et al.
Published: (2019-04-01)
by: Enrico Ragni, et al.
Published: (2019-04-01)
Cartilage Protective and Immunomodulatory Features of Osteoarthritis Synovial Fluid-Treated Adipose-Derived Mesenchymal Stem Cells Secreted Factors and Extracellular Vesicles-Embedded miRNAs
by: Enrico Ragni, et al.
Published: (2021-04-01)
by: Enrico Ragni, et al.
Published: (2021-04-01)
Adipose-Derived Mesenchymal Stromal Cells Treated with Interleukin 1 Beta Produced Chondro-Protective Vesicles Able to Fast Penetrate in Cartilage
by: Alessandra Colombini, et al.
Published: (2021-05-01)
by: Alessandra Colombini, et al.
Published: (2021-05-01)
miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells
by: Enrico Ragni, et al.
Published: (2021-02-01)
by: Enrico Ragni, et al.
Published: (2021-02-01)
A2A adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields
by: Alessandra Colombini, et al.
Published: (2020-01-01)
by: Alessandra Colombini, et al.
Published: (2020-01-01)
In Vitro Study of Extracellular Vesicles Migration in Cartilage-Derived Osteoarthritis Samples Using Real-Time Quantitative Multimodal Nonlinear Optics Imaging
by: Leonardo Mortati, et al.
Published: (2020-08-01)
by: Leonardo Mortati, et al.
Published: (2020-08-01)
miRNA Reference Genes in Extracellular Vesicles Released from Amniotic Membrane-Derived Mesenchymal Stromal Cells
by: Enrico Ragni, et al.
Published: (2020-04-01)
by: Enrico Ragni, et al.
Published: (2020-04-01)
Reliable Reference Genes for Gene Expression Assessment in Tendon-Derived Cells under Inflammatory and Pro-Fibrotic/Healing Stimuli
by: Enrico Ragni, et al.
Published: (2019-10-01)
by: Enrico Ragni, et al.
Published: (2019-10-01)
Endogenous Controls for the Evaluation of Osteoarthritis-Related miRNAs in Extracellular Vesicles from Bone-Marrow-Derived Mesenchymal Stromal Cells and the Impact of Osteoarthritis Synovial Fluid
by: Enrico Ragni, et al.
Published: (2022-02-01)
by: Enrico Ragni, et al.
Published: (2022-02-01)
Secreted Factors and Extracellular Vesicles Account for the Immunomodulatory and Tissue Regenerative Properties of Bone-Marrow-Derived Mesenchymal Stromal Cells for Osteoarthritis
by: Enrico Ragni, et al.
Published: (2022-11-01)
by: Enrico Ragni, et al.
Published: (2022-11-01)
Amniotic membrane‐mesenchymal stromal cells secreted factors and extracellular vesicle‐miRNAs: Anti‐inflammatory and regenerative features for musculoskeletal tissues
by: Enrico Ragni, et al.
Published: (2021-07-01)
by: Enrico Ragni, et al.
Published: (2021-07-01)
Joint Tissue Protective and Immune-Modulating miRNA Landscape of Mesenchymal Stromal Cell-Derived Extracellular Vesicles under Different Osteoarthritis-Mimicking Conditions
by: Enrico Ragni, et al.
Published: (2022-07-01)
by: Enrico Ragni, et al.
Published: (2022-07-01)
LIPO-AMIC Technique Description: Autologous Matrix Induced–Chondrogenesis With Microfragmented Adipose Tissue Graft
by: Pedro Debieux, M.D., Ph.D., et al.
Published: (2025-03-01)
by: Pedro Debieux, M.D., Ph.D., et al.
Published: (2025-03-01)
Molecular Characterization of Secreted Factors and Extracellular Vesicles-Embedded miRNAs from Bone Marrow-Derived Mesenchymal Stromal Cells in Presence of Synovial Fluid from Osteoarthritis Patients
by: Enrico Ragni, et al.
Published: (2022-11-01)
by: Enrico Ragni, et al.
Published: (2022-11-01)
Autologous Microfragmented Adipose Tissue Injection Combined With Core Decompression for Treatment of Early-Stage Osteonecrosis of the Femoral Head
by: Zhenhan Deng, M.D., Ph.D., et al.
Published: (2025-06-01)
by: Zhenhan Deng, M.D., Ph.D., et al.
Published: (2025-06-01)
Effects of Autologous Microfragmented Adipose Tissue on Healing of Tibial Plateau Levelling Osteotomies in Dogs: A Prospective Clinical Trial
by: Luca Pennasilico, et al.
Published: (2023-06-01)
by: Luca Pennasilico, et al.
Published: (2023-06-01)
The effects of orthobiologics in the treatment of tendon pathologies: a systematic review of preclinical evidence
by: Marco Viganò, et al.
Published: (2022-01-01)
by: Marco Viganò, et al.
Published: (2022-01-01)
Long-Lasting Anti-Inflammatory Activity of Human Microfragmented Adipose Tissue
by: Sara Nava, et al.
Published: (2019-01-01)
by: Sara Nava, et al.
Published: (2019-01-01)
Preliminary Study on the Echo-Assisted Intersphincteric Autologous Microfragmented Adipose Tissue Injection to Control Fecal Incontinence in Children Operated for Anorectal Malformations
by: Giovanni Parente, et al.
Published: (2020-10-01)
by: Giovanni Parente, et al.
Published: (2020-10-01)
Microfragmented Adipose Tissue Associated With Collagen Membrane in the Treatment of Focal Knee Cartilage Defect
by: Daniel Peixoto Leal, M.D., et al.
Published: (2024-10-01)
by: Daniel Peixoto Leal, M.D., et al.
Published: (2024-10-01)
Innovative Visualization and Quantification of Extracellular Vesicles Interaction with and Incorporation in Target Cells in 3D Microenvironments
by: Enrico Ragni, et al.
Published: (2020-05-01)
by: Enrico Ragni, et al.
Published: (2020-05-01)
In Vitro Characterization of Canine Microfragmented Adipose Tissue Non-Enzymatically Extracted from the Thigh and Lumbar Regions
by: Francesco De Francesco, et al.
Published: (2021-11-01)
by: Francesco De Francesco, et al.
Published: (2021-11-01)
Lipogems Product Treatment Increases the Proliferation Rate of Human Tendon Stem Cells without Affecting Their Stemness and Differentiation Capability
by: Pietro Randelli, et al.
Published: (2016-01-01)
by: Pietro Randelli, et al.
Published: (2016-01-01)
Rationale and pre-clinical evidences for the use of autologous cartilage micrografts in cartilage repair
by: Marco Viganò, et al.
Published: (2018-11-01)
by: Marco Viganò, et al.
Published: (2018-11-01)
Mechanism of action behind the pain-relief effects of extracellular vesicles in microfragmented adipose tissue: an in vitro and in vivo study
by: Francesco De Francesco, et al.
Published: (2025-08-01)
by: Francesco De Francesco, et al.
Published: (2025-08-01)
Microfragmented adipose tissue is associated with improved ex vivo performance linked to HOXB7 and b-FGF expression
by: Giulia Casari, et al.
Published: (2021-08-01)
by: Giulia Casari, et al.
Published: (2021-08-01)
Arthroscopic treatment of chondral defects in the hip: AMIC, MACI, microfragmented adipose tissue transplantation (MATT) and other options
by: Jannelli Eugenio, et al.
Published: (2017-01-01)
by: Jannelli Eugenio, et al.
Published: (2017-01-01)
Advances in Musculoskeletal Cell Therapy: Basic Science and Translational Approaches
by: Enrico Ragni, et al.
Published: (2022-11-01)
by: Enrico Ragni, et al.
Published: (2022-11-01)
Cryophysiology of coral microfragments: effects of chilling and cryoprotectant toxicity
by: Claire V. A. Lager, et al.
Published: (2024-11-01)
by: Claire V. A. Lager, et al.
Published: (2024-11-01)
Tank fouling community enhances coral microfragment growth
by: Christopher Page, et al.
Published: (2023-08-01)
by: Christopher Page, et al.
Published: (2023-08-01)
Patient-Centered Outcomes of Microfragmented Adipose Tissue Treatments of Knee Osteoarthritis: An Observational, Intention-to-Treat Study at Twelve Months
by: Nima Heidari, et al.
Published: (2020-01-01)
by: Nima Heidari, et al.
Published: (2020-01-01)
SP26. Efficacy of Microfragmented Adipose Tissue for Treatment of Symptomatic Knee Osteoarthritis: A Randomized, Placebo-controlled Study
by: Joshua Luke Harrison, MD, et al.
Published: (2023-05-01)
by: Joshua Luke Harrison, MD, et al.
Published: (2023-05-01)
Treatment with CR500® improves algofunctional scores in patients with knee osteoarthritis: a post-market confirmatory interventional, single arm clinical investigation
by: Alessandra Colombini, et al.
Published: (2023-08-01)
by: Alessandra Colombini, et al.
Published: (2023-08-01)
Intervertebral disc and endplate cell characterisation highlights annulus fibrosus cells as the most promising for tissue-specific disc degeneration therapy
by: P De Luca, et al.
Published: (2020-03-01)
by: P De Luca, et al.
Published: (2020-03-01)
Chemical Activation of the Hypoxia-Inducible Factor Reversibly Reduces Tendon Stem Cell Proliferation, Inhibits Their Differentiation, and Maintains Cell Undifferentiation
by: Alessandra Menon, et al.
Published: (2018-01-01)
by: Alessandra Menon, et al.
Published: (2018-01-01)
Regenerative medicine at the equator of women's health and quality of life: the role of microfragmented stromal-vascular fraction of adipose tissue in modern regenerative medicine
by: Mekan R. Orazov, et al.
Published: (2024-03-01)
by: Mekan R. Orazov, et al.
Published: (2024-03-01)
63 Successful isolation of viable stem cells from cryopreserved microfragmented human abdominal adipose tissue from patients with knee osteoarthritis
by: Per Hölmich, et al.
Published: (2023-02-01)
by: Per Hölmich, et al.
Published: (2023-02-01)
Differential Effects of Substrate Type and Genet on Growth of Microfragments of Acropora palmata
by: Erin Papke, et al.
Published: (2021-04-01)
by: Erin Papke, et al.
Published: (2021-04-01)
Zeolite-microfragmenting Media: A Potential Strategy to Accelerate Coral Growth
by: Mujahidah Khaulah, et al.
Published: (2023-01-01)
by: Mujahidah Khaulah, et al.
Published: (2023-01-01)
Treatment with Human Amniotic Suspension Allograft Improves Tendon Healing in a Rat Model of Collagenase-Induced Tendinopathy
by: Laura de Girolamo, et al.
Published: (2019-11-01)
by: Laura de Girolamo, et al.
Published: (2019-11-01)
Similar Items
-
Insights into Inflammatory Priming of Adipose-Derived Mesenchymal Stem Cells: Validation of Extracellular Vesicles-Embedded miRNA Reference Genes as A Crucial Step for Donor Selection
by: Enrico Ragni, et al.
Published: (2019-04-01) -
Cartilage Protective and Immunomodulatory Features of Osteoarthritis Synovial Fluid-Treated Adipose-Derived Mesenchymal Stem Cells Secreted Factors and Extracellular Vesicles-Embedded miRNAs
by: Enrico Ragni, et al.
Published: (2021-04-01) -
Adipose-Derived Mesenchymal Stromal Cells Treated with Interleukin 1 Beta Produced Chondro-Protective Vesicles Able to Fast Penetrate in Cartilage
by: Alessandra Colombini, et al.
Published: (2021-05-01) -
miR-103a-3p and miR-22-5p Are Reliable Reference Genes in Extracellular Vesicles From Cartilage, Adipose Tissue, and Bone Marrow Cells
by: Enrico Ragni, et al.
Published: (2021-02-01) -
A2A adenosine receptors are involved in the reparative response of tendon cells to pulsed electromagnetic fields
by: Alessandra Colombini, et al.
Published: (2020-01-01)
