Astrocytic Propagation of Tau in the Context of Alzheimer's Disease
More than 6 million Americans are currently living with Alzheimer's disease (AD), and the incidence is growing rapidly with our aging population. Numerous therapeutics have failed to make it to the clinic, potentially due to a focus on presumptive pathogenic proteins instead of cell-type-specif...
| Published in: | Frontiers in Cellular Neuroscience |
|---|---|
| Main Authors: | Rebecca M. Fleeman, Elizabeth A. Proctor |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2021.645233/full |
Similar Items
Extracellular Monomeric Tau Is Internalized by Astrocytes
by: Juan Ramón Perea, et al.
Published: (2019-05-01)
by: Juan Ramón Perea, et al.
Published: (2019-05-01)
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
by: Khalid Eltom, et al.
Published: (2024-02-01)
by: Khalid Eltom, et al.
Published: (2024-02-01)
Implication of tau propagation on neurodegeneration in Alzheimer’s disease
by: Daniel Lamontagne-Kam, et al.
Published: (2023-07-01)
by: Daniel Lamontagne-Kam, et al.
Published: (2023-07-01)
Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimagingResearch in context
by: Stephanie Doering, et al.
Published: (2024-05-01)
by: Stephanie Doering, et al.
Published: (2024-05-01)
Cerebrospinal fluid neuronal pentraxin levels are associated with tau pathology via microglia–astrocyte signaling in alzheimer’s disease
by: Zihao Zhang, et al.
Published: (2025-10-01)
by: Zihao Zhang, et al.
Published: (2025-10-01)
Pathological Tau From Alzheimer’s Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau in vivo
by: Jin Miao, et al.
Published: (2019-03-01)
by: Jin Miao, et al.
Published: (2019-03-01)
Role of Microglial Cells in Alzheimer’s Disease Tau Propagation
by: Ena Španić, et al.
Published: (2019-10-01)
by: Ena Španić, et al.
Published: (2019-10-01)
Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
by: Yijun Chen, et al.
Published: (2023-07-01)
by: Yijun Chen, et al.
Published: (2023-07-01)
Propagation of Tau via Extracellular Vesicles
by: Mar Pérez, et al.
Published: (2019-07-01)
by: Mar Pérez, et al.
Published: (2019-07-01)
Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease
by: Zehu Sheng, et al.
Published: (2025-01-01)
by: Zehu Sheng, et al.
Published: (2025-01-01)
Astrocyte reactivity is associated with tau tangle load and cortical thinning in Alzheimer’s disease
by: Tengfei Guo, et al.
Published: (2024-07-01)
by: Tengfei Guo, et al.
Published: (2024-07-01)
Glymphatic inhibition exacerbates tau propagation in an Alzheimer’s disease model
by: Douglas M. Lopes, et al.
Published: (2024-04-01)
by: Douglas M. Lopes, et al.
Published: (2024-04-01)
Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease
by: Xi-Lin Wu, et al.
Published: (2017-01-01)
by: Xi-Lin Wu, et al.
Published: (2017-01-01)
Two simple assays for assessing the seeding activity of proteopathic tau
by: Fei Liu, et al.
Published: (2023-04-01)
by: Fei Liu, et al.
Published: (2023-04-01)
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
by: Sarah L. DeVos, et al.
Published: (2018-04-01)
by: Sarah L. DeVos, et al.
Published: (2018-04-01)
Astrocytes Derived from Familial and Sporadic Alzheimer’s Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau
by: Veronika Brezovakova, et al.
Published: (2022-04-01)
by: Veronika Brezovakova, et al.
Published: (2022-04-01)
Aging-Related Tau Astrogliopathy in Aging and Neurodegeneration
by: Heather McCann, et al.
Published: (2021-07-01)
by: Heather McCann, et al.
Published: (2021-07-01)
Nanotechnology for tau pathology in Alzheimer's disease
by: Rongrong Ma, et al.
Published: (2024-08-01)
by: Rongrong Ma, et al.
Published: (2024-08-01)
Toxic tau: structural origins of tau aggregation in Alzheimer's disease
by: Abdullah Al Mamun, et al.
Published: (2020-01-01)
by: Abdullah Al Mamun, et al.
Published: (2020-01-01)
Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer’s Disease
by: Yan Zhou, et al.
Published: (2018-02-01)
by: Yan Zhou, et al.
Published: (2018-02-01)
Plasma N-terminal containing tau fragments (NTA-tau): a biomarker of tau deposition in Alzheimer’s Disease
by: Juan Lantero-Rodriguez, et al.
Published: (2024-02-01)
by: Juan Lantero-Rodriguez, et al.
Published: (2024-02-01)
Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease
by: Akihiro Kitani, et al.
Published: (2025-04-01)
by: Akihiro Kitani, et al.
Published: (2025-04-01)
Tau Propagation as a Diagnostic and Therapeutic Target for Dementia: Potentials and Unanswered Questions
by: Shuko Takeda
Published: (2019-12-01)
by: Shuko Takeda
Published: (2019-12-01)
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau
by: Lenka Hromadkova, et al.
Published: (2023-09-01)
by: Lenka Hromadkova, et al.
Published: (2023-09-01)
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription
by: Rosemary J. Jackson, et al.
Published: (2024-08-01)
by: Rosemary J. Jackson, et al.
Published: (2024-08-01)
Retinal tau phosphorylation in Alzheimer's disease: A mass spectrometry study
by: Jessica Santiago, et al.
Published: (2025-10-01)
by: Jessica Santiago, et al.
Published: (2025-10-01)
Plasma tau complements CSF tau and P‐tau in the diagnosis of Alzheimer's disease
by: Silvia Fossati, et al.
Published: (2019-12-01)
by: Silvia Fossati, et al.
Published: (2019-12-01)
Astrocytic uptake of neuronal corpses promotes cell-to-cell spreading of tau pathology
by: Tobias Mothes, et al.
Published: (2023-06-01)
by: Tobias Mothes, et al.
Published: (2023-06-01)
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
by: Senthilvelrajan Kaniyappan, et al.
Published: (2020-07-01)
by: Senthilvelrajan Kaniyappan, et al.
Published: (2020-07-01)
P‐tau235: a novel biomarker for staging preclinical Alzheimer’s disease
by: Juan Lantero‐Rodriguez, et al.
Published: (2021-11-01)
by: Juan Lantero‐Rodriguez, et al.
Published: (2021-11-01)
A nonhuman primate model with Alzheimer’s disease-like pathology induced by hippocampal overexpression of human tau
by: Zhouquan Jiang, et al.
Published: (2024-01-01)
by: Zhouquan Jiang, et al.
Published: (2024-01-01)
Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease
by: Kelly Ceyzériat, et al.
Published: (2024-10-01)
by: Kelly Ceyzériat, et al.
Published: (2024-10-01)
CSF metabolites associate with CSF tau and improve prediction of Alzheimer's disease status
by: Ruocheng Dong, et al.
Published: (2021-01-01)
by: Ruocheng Dong, et al.
Published: (2021-01-01)
Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease
by: Zhi-Bo Wang, et al.
Published: (2022-12-01)
by: Zhi-Bo Wang, et al.
Published: (2022-12-01)
Tau Transfer via Extracellular Vesicles Disturbs the Astrocytic Mitochondrial System
by: Romain Perbet, et al.
Published: (2023-03-01)
by: Romain Perbet, et al.
Published: (2023-03-01)
Soluble P‐tau217 reflects amyloid and tau pathology and mediates the association of amyloid with tau
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-05-01)
by: Niklas Mattsson‐Carlgren, et al.
Published: (2021-05-01)
Baicalein inhibits heparin-induced Tau aggregation by initializing non-toxic Tau oligomer formation
by: Shweta Kishor Sonawane, et al.
Published: (2021-02-01)
by: Shweta Kishor Sonawane, et al.
Published: (2021-02-01)
Tau in neurodegenerative diseases: molecular mechanisms, biomarkers, and therapeutic strategies
by: Xingyu Zhang, et al.
Published: (2024-08-01)
by: Xingyu Zhang, et al.
Published: (2024-08-01)
P-tau217 as a Reliable Blood-Based Marker of Alzheimer’s Disease
by: Roy Lai, et al.
Published: (2024-08-01)
by: Roy Lai, et al.
Published: (2024-08-01)
Tau Secretion: Good and Bad for Neurons
by: Camille Pernègre, et al.
Published: (2019-06-01)
by: Camille Pernègre, et al.
Published: (2019-06-01)
Similar Items
-
Extracellular Monomeric Tau Is Internalized by Astrocytes
by: Juan Ramón Perea, et al.
Published: (2019-05-01) -
Astrocytic accumulation of tau fibrils isolated from Alzheimer’s disease brains induces inflammation, cell-to-cell propagation and neuronal impairment
by: Khalid Eltom, et al.
Published: (2024-02-01) -
Implication of tau propagation on neurodegeneration in Alzheimer’s disease
by: Daniel Lamontagne-Kam, et al.
Published: (2023-07-01) -
Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimagingResearch in context
by: Stephanie Doering, et al.
Published: (2024-05-01) -
Cerebrospinal fluid neuronal pentraxin levels are associated with tau pathology via microglia–astrocyte signaling in alzheimer’s disease
by: Zihao Zhang, et al.
Published: (2025-10-01)
