3,4-dihydroxyphenylethyl alcohol glycoside reduces acetaminophen-induced acute liver failure in mice by inhibiting hepatocyte ferroptosis and pyroptosis

APAP is one of the most commonly used antipyretic and pain medications, but excessive use can cause liver toxicity and damage. 3,4-dihydroxyphenylethyl alcohol glycoside (DAG) is a component isolated from Sargentodoxa cuneata known to have anti-apoptotic, anti-oxidation and anti-inflammatory effects...

Full description

Bibliographic Details
Published in:	PeerJ
Main Authors:	Tianyu Liu, Lei Yang, Hejun Gao, Yuzhen Zhuo, Zhengwei Tu, Yongqin Wang, Jing Xun, Qi Zhang, Lanqiu Zhang, Ximo Wang
Format:	Article
Language:	English
Published:	PeerJ Inc. 2022-03-01
Subjects:	Acetaminophen Acute liver failure Ferroptosis Pyroptosis 3,4-dihydroxyphenylethyl alcohol glycoside
Online Access:	https://peerj.com/articles/13082.pdf

Similar Items

Whey protein hydrolysate alleviated acetaminophen-induced hepatocyte pyroptosis by activating mitophagy
by: S. Zhang, et al.
Published: (2025-08-01)

Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity
by: Hartmut Jaeschke, et al.
Published: (2022-12-01)

Glycyrrhizic acid glycosides reduces extensive tripterygium glycosides-induced lipid deposition in hepatocytes
by: Yifei Yang, et al.
Published: (2023-07-01)

Acylcarnitine Profiles in Acetaminophen Toxicity in the Mouse: Comparison to Toxicity, Metabolism and Hepatocyte Regeneration
by: Jack Hinson, et al.
Published: (2013-08-01)

Lipin3 deficiency promotes hepatocyte ferroptosis and pyroptosis via activating JAK1-STAT3 pathway during acetaminophen induced acute liver injury
by: Yu-Xing Liu, et al.
Published: (2025-10-01)

Acetaminophen overdose associated with double serum concentration peaks
by: Cristian Papazoglu, et al.
Published: (2015-12-01)

On the safety of acetaminophen
by: R. N. Alyautdin, et al.
Published: (2022-06-01)

Comparison of Acetaminophen with or without Codeine to Ibuprofen on the Postoperative Pain of Pediatric Tonsillectomy
Published: (2011-04-01)

Ibuprofen and Acetaminophen Antipyretic Efficacy
by: J Gordon Millichap
Published: (1995-06-01)

Syringaresinol alleviates acetaminophen-induced hepatocyte ferroptosis through the Nrf2/HO-1 pathway by targeting Caveolin-1
by: Lei Cao, et al.
Published: (2026-05-01)

Protective Effects of Apamin on Acetaminophen-Induced Hepatotoxicity in Mice
by: Hyo-Jeong Jang, et al.
Published: (2023-05-01)

Modelling Tools to Characterize Acetaminophen Pharmacokinetics in the Pregnant Population
by: Sofie A. M. Brookhuis, et al.
Published: (2021-08-01)

Testing of Candidate Icons to Identify Acetaminophen-Containing Medicines
by: Saul Shiffman, et al.
Published: (2016-01-01)

The clinical value of screening for acetaminophen in all patients with intentional overdose or altered mental status suspected to be secondary to overdose
by: Bader Alyahya, et al.
Published: (2025-07-01)

Veronica anagallis-aquatica L. iridoid glycosides alleviate heart failure via metabolites homoveratrumic acid and 2-hydroxy-3,4-dimethoxybenzoic acid mediated by the gut microbiota
by: Manjiong Wang, et al.
Published: (2025-06-01)

Gene Expression Signatures in AML-12 Hepatocyte Cells upon <i>Dengue virus</i> Infection and Acetaminophen Treatment
by: Jorge G. G. Ferreira, et al.
Published: (2020-11-01)

Impact of malnourishment on the pharmacokinetics of acetaminophen and susceptibility to acetaminophen hepatotoxicity
by: Daan Zillen, et al.
Published: (2021-11-01)

Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder
by: Yuelong Ji, et al.
Published: (2018-07-01)

Effect of Fructose in Acetaminophen Induced Liver Injury in Rats
by: Fareeha Farooq, et al.
Published: (2010-08-01)

Acetaminophen-induced hypotension in sepsis
by: Shunsuke Inage, et al.
Published: (2022-05-01)

Lignan Glycosides and Flavonoid Glycosides from the Aerial Portion of Lespedeza cuneata and Their Biological Evaluations
by: Jiwon Baek, et al.
Published: (2018-08-01)

High-Dose Acetaminophen as a Treatment for Cancer
by: Jeffrey Wu, et al.
Published: (2024-01-01)

Gastric emptying in rats with acetaminophen-induced hepatitis
by: G. Hessel, et al.
Published: (1998-09-01)

Structural mechanism of a dual-functional enzyme DgpA/B/C as both a C-glycoside cleaving enzyme and an O- to C-glycoside isomerase
by: Pengfei He, et al.
Published: (2023-01-01)

Acetaminophen Mimics the Action of Salbutamol in Relaxing Gravid Human Uterus - In - Vitro
by: Mahdi I. Hilmy
Published: (2007-04-01)

Hepatoprotective Potentials of Dates Extract (Phoenix dactylifera) in Acetaminophen-Induced Mice
by: Andriyanto Andriyanto, et al.
Published: (2023-09-01)

Pharmacogenomics of Acetaminophen in Pediatric Populations: a Moving Target
by: Wanqing eLiu
Published: (2014-10-01)

Efficacy of a Single Dose Administration of Ibuprofen and Acetaminophen in Comparison with Acetaminophen for the Relief of Perineal Pain after Childbirth: A randomized controlled trial
by: Preeyaporn Harasai, et al.
Published: (2020-01-01)

The role and mechanisms of macrophage polarization and hepatocyte pyroptosis in acute liver failure
by: Dan Xie, et al.
Published: (2023-10-01)

Macrophage-derived exosomal miR-155 regulating hepatocyte pyroptosis in MAFLD
by: Wei He, et al.
Published: (2024-08-01)

Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy
by: Lisa Zhao, et al.
Published: (2024-03-01)

Preparative Isolation and Purification of Five Flavonoid Glycosides and One Benzophenone Galloyl Glycoside from Psidium guajava by High-Speed Counter-Current Chromatography (HSCCC)
by: Yindi Zhu, et al.
Published: (2013-12-01)

Comparison of Flavonoid O-Glycoside, C-Glycoside and Their Aglycones on Antioxidant Capacity and Metabolism during In Vitro Digestion and In Vivo
by: Liangqin Xie, et al.
Published: (2022-03-01)

A dual role of inflammation in acetaminophen-induced liver injury
by: Long Xu, et al.
Published: (2023-03-01)

Acute pancreatitis after nifedipine and acetaminophen poisoning — case report
by: Sorodoc Laurentiu, et al.
Published: (2009-12-01)

Comparative single intraperitoneal dose pharmacokinetics of aspirin and acetaminophen in chicks
by: F.K. Mohammad, et al.
Published: (2012-03-01)

Protective effect of chitosan treatment against acetaminophen-induced hepatotoxicity
by: Eda Ozcelik, et al.
Published: (2014-06-01)

The role of fomepizole in acetaminophen-related poisoning: a narrative review
by: Frank Chen, et al.
Published: (2026-03-01)

Photoluminescence as a Valuable Tool in the Optical Characterization of Acetaminophen and the Monitoring of Its Photodegradation Reactions
by: Monica Daescu, et al.
Published: (2020-10-01)

Evaluation of clinical findings of acetaminophen poisoning and factors associated with its severity in poisoned patients
by: Hamid Mohammadi Kojidi, et al.
Published: (2022-09-01)