A Case-Study of Implementation of Improved Strategies for Prevention of Laboratory-acquired Brucellosis

• 出版年: Safety and Health at Work
• 主要な著者: Louisa J. Castrodale, Gregory A. Raczniak, Karen M. Rudolph, Lori Chikoyak, Russell S. Cox, Tricia L. Franklin, Rita M. Traxler, Marta Guerra
• フォーマット: 論文
• 言語: 英語
• 出版事項: Elsevier 2015-12-01
• 主題: Alaska; brucellosis; laboratory-acquired infections; laboratory-associated brucellosis; laboratory biosafety
• オンライン･アクセス: http://www.sciencedirect.com/science/article/pii/S2093791115000657
• ISSN: 2093-7911

Background: In 2012, the Alaska Section of Epidemiology investigated personnel potentially exposed to a Brucella suis isolate as it transited through three laboratories. Methods: We summarize the first implementation of the United States Centers for Disease Control and Prevention 2013 revised recommendations for monitoring such exposures: (1) risk classification; (2) antimicrobial postexposure prophylaxis; (3) serologic monitoring; and (4) symptom surveillance. Results: Over 30 people were assessed for exposure and subsequently monitored for development of illness. No cases of laboratory-associated brucellosis occurred. Changes were made to gaps in laboratory biosafety practices that had been identified in the investigation. Conclusion: Achieving full compliance for the precise schedule of serologic monitoring was challenging and resource intensive for the laboratory performing testing. More refined exposure assessments could inform decision making for follow-up to maximize likelihood of detecting persons at risk while not overtaxing resources.