α-Cyclodextrin/Moringin Induces an Antioxidant Transcriptional Response Activating Nrf2 in Differentiated NSC-34 Motor Neurons

Oxidative stress is a common feature of neurodegenerative diseases. Different natural compounds mediate neuroprotective effects by activating the Nrf2 antioxidant response. Some isothiocyanates are Nrf2 activators, including Moringin (MOR). In this study, the transcriptional profile of differentiate...

Full description

Bibliographic Details
Published in:	Antioxidants
Main Authors:	Agnese Gugliandolo, Gabriella Calì, Claudia Muscarà, Osvaldo Artimagnella, Patrick Rollin, Daniele Perenzoni, Renato Iori, Emanuela Mazzon, Luigi Chiricosta
Format:	Article
Language:	English
Published:	MDPI AG 2024-07-01
Subjects:	Moringin motor neurons isothiocyanate Nrf2 transcriptomic analysis
Online Access:	https://www.mdpi.com/2076-3921/13/7/813

Similar Items

The Moringin/α-CD Pretreatment Induces Neuroprotection in an In Vitro Model of Alzheimer’s Disease: A Transcriptomic Study
by: Serena Silvestro, et al.
Published: (2021-05-01)

Cardio- and neuroprotective effects by pretreatment of dietary moringin from Moringa oleifera seeds and α-CD/moringin formulation in a rat model of isoproterenol-induced myocardial infarction
by: Ahmad Faizal Abdull Razis, et al.
Published: (2025-01-01)

Multi-Target Antibacterial Mechanism of Moringin From Moringa oleifera Seeds Against Listeria monocytogenes
by: Yanlong Wen, et al.
Published: (2022-06-01)

Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment
by: Sabrina Giacoppo, et al.
Published: (2017-07-01)

Bioactivated Glucoraphanin Modulates Genes Involved in Necroptosis on Motor-Neuron-like Nsc-34: A Transcriptomic Study
by: Aurelio Minuti, et al.
Published: (2024-09-01)

Histopathological and ultrastructural alterations reveal the hepatotoxicity of lead against Moringin: Sub-chronic-chemotherapeutic trial
by: Mohammed Abdulabbas Hasan
Published: (2025-07-01)

Cannabinerol (CBNR) Influences Synaptic Genes Associated with Cytoskeleton and Ion Channels in NSC-34 Cell Line: A Transcriptomic Study
by: Osvaldo Artimagnella, et al.
Published: (2024-01-01)

Glucosinolate Metabolites and Brain Health: An Updated Review on Their Potential Benefits in Neurodegenerative, Neurodevelopmental, and Psychiatric Disorders
by: Claudia Muscarà, et al.
Published: (2025-07-01)

Anatomical and Chemical Analysis of <i>Moringa oleifera</i> Stem Tissue Grown under Controlled Conditions
by: Holly M. McVea, et al.
Published: (2023-02-01)

Cannabinol (CBN) Influences the Ion Channels and Synaptic-Related Genes in NSC-34 Cell Line: A Transcriptomic Study
by: Alessandra Trainito, et al.
Published: (2024-09-01)

Will Cannabigerol Trigger Neuroregeneration after a Spinal Cord Injury? An In Vitro Answer from NSC-34 Scratch-Injured Cells Transcriptome
by: Andrea Valeri, et al.
Published: (2022-01-01)

Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study
by: Ivan Anchesi, et al.
Published: (2023-01-01)

The Transcriptomic Analysis of NSC-34 Motor Neuron-Like Cells Reveals That Cannabigerol Influences Synaptic Pathways: A Comparative Study with Cannabidiol
by: Agnese Gugliandolo, et al.
Published: (2020-10-01)

Cannabinol Regulates the Expression of Cell Cycle-Associated Genes in Motor Neuron-like NSC-34: A Transcriptomic Analysis
by: Alessandra Trainito, et al.
Published: (2024-06-01)

Transcriptomic Profiling after In Vitro Δ<sup>8</sup>-THC Exposure Shows Cytoskeletal Remodeling in Trauma-Injured NSC-34 Cell Line
by: Luigi Chiricosta, et al.
Published: (2023-09-01)

Cannabichromene Induces Neuronal Differentiation in NSC-34 Cells: Insights from Transcriptomic Analysis
by: Andrea Valeri, et al.
Published: (2023-03-01)

Phytochemical Analyses, Antioxidant and Anticancer Activities of Ethanolic Leaf Extracts of <i>Moringa oleifera</i> Lam. Varieties
by: Bilques Farooq, et al.
Published: (2021-10-01)

Cannabinerol Prevents Endoplasmic Reticulum and Mitochondria Dysfunctions in an In Vitro Model of Alzheimer’s Disease: A Network-Based Transcriptomic Analysis
by: Luigi Chiricosta, et al.
Published: (2024-06-01)

Synthesis of PEITC-loaded gold nanoparticles and evaluation of the hepatoprotective effect on CCl4-induced damage through Nrf2 pathway
by: Uyumlu Ayşe Burçin, et al.
Published: (2023-01-01)

An Evaluation of the Anti-Carcinogenic Response of Major Isothiocyanates in Non-Metastatic and Metastatic Melanoma Cells
by: Melina Mitsiogianni, et al.
Published: (2021-02-01)

The Reaction of Allyl Isothiocyanate with Hydroxyl/Water and β-Cyclodextrin Using Ultraviolet Spectrometry
by: Zi-Tao Jiang, et al.
Published: (2006-01-01)

Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
by: Rosaliana Libro, et al.
Published: (2016-04-01)

Antiallergic Effect of the Alpha-Cyclodextrin Moringin Complex in Rat Basophilic Leukaemia (RBL-2H3) Cell Line
by: Ebtisam Yousef A. Alnakeeb, et al.
Published: (2024-01-01)

Molecular Mechanisms of the Anti-Cancer Effects of Isothiocyanates from Cruciferous Vegetables in Bladder Cancer
by: Tomhiro Mastuo, et al.
Published: (2020-01-01)

Effect of Prooxidative Natural Products: Comparison of the OSI1 (YKL071w) Promoter Luciferase Construct from Yeast with an Nrf2/Keap Reporter System
by: Ivan Schlembach, et al.
Published: (2020-05-01)

Preparation of Eugenol–Thymol–Cuminal Composite Essential Oil Microcapsules with AITC & β-Cyclodextrin Inclusion Complex and Its Effect on Quality of Chilled Pork
by: Wenxiao Li, et al.
Published: (2025-03-01)

Benzyl isothiocyanate ameliorates cognitive function in mice of chronic temporal lobe epilepsy
by: Chang Xiaoyu, et al.
Published: (2024-04-01)

Beneficial Health Effects of Glucosinolates-Derived Isothiocyanates on Cardiovascular and Neurodegenerative Diseases
by: Ramla Muhammad Kamal, et al.
Published: (2022-01-01)

Effects of Four Isothiocyanates in Dissolved and Gaseous States on the Growth and Aflatoxin Production of <i>Aspergillus flavus</i> In Vitro
by: Yohei Hareyama, et al.
Published: (2022-11-01)

Retraction Note: Moringa isothiocyanate complexed with α-cyclodextrin: a new perspective in neuroblastoma treatment
by: Sabrina Giacoppo, et al.
Published: (2023-03-01)

Formulation of Broccoli Sprout Powder in Gastro-Resistant Capsules Protects against the Acidic pH of the Stomach In Vitro but Does Not Increase Isothiocyanate Bioavailability In Vivo
by: Masuma Zawari, et al.
Published: (2019-09-01)

Encapsulation of Benzyl Isothiocyanate with β-Cyclodextrin Using Ultrasonication: Preparation, Characterization, and Antibacterial Assay
by: Hongbo Li, et al.
Published: (2022-11-01)

Systems biology reveals anatabine to be an NRF2 activator
by: Dimitris E. Messinis, et al.
Published: (2022-11-01)

Naturally Derived Phenethyl Isothiocyanate Modulates Induction of Oxidative Stress via Its <i>N</i>-Acetylated Cysteine Conjugated form in Malignant Melanoma
by: Sotiris Kyriakou, et al.
Published: (2024-01-01)

Allyl isothiocyanate affects the cell cycle of Arabidopsis thaliana
by: Signe Elisabeth Åsberg, et al.
Published: (2015-05-01)

Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells
by: Asvinidevi Arumugam, et al.
Published: (2020-03-01)

Release and Disintegration Properties of Poly(lactic Acid) Films with Allyl Isothiocyanate-β-Cyclodextrin Inclusion Complexes for Active Food Packaging
by: Cristina Muñoz-Shugulí, et al.
Published: (2024-12-01)

Characterization of the Inclusion Complexes of Isothiocyanates with γ-Cyclodextrin for Improvement of Antibacterial Activities against <i>Staphylococcus aureus</i>
by: Jianan Liu, et al.
Published: (2021-12-01)

Cooking Methods for Preserving Isothiocyanates and Reducing Goitrin in <i>Brassica</i> Vegetables
by: Thanaporn Panduang, et al.
Published: (2023-10-01)

Potential Anti-Inflammatory Effects of a New Lyophilized Formulation of the Conditioned Medium Derived from Periodontal Ligament Stem Cells
by: Agnese Gugliandolo, et al.
Published: (2022-03-01)