Rate of Adriamycin Resistance Associated (ARA) long Noncoding RNA Expression in Sample of Hepatitis B Virus Iraqi Patients
Numerous biological processes, including epigenetics regulation, control of cell cycle, beside transcriptional, translational and regulation of genes expression, have been linked to long non-coding RNAs lncRNAs . the disruption of expression for lncRNAs are important early stages in in hepatitis B...
| Published in: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
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| Main Author: | |
| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2024-10-01
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| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/1087 |
| Summary: | Numerous biological processes, including epigenetics regulation, control of cell cycle, beside transcriptional, translational and regulation of genes expression, have been linked to long non-coding RNAs lncRNAs . the disruption of expression for lncRNAs are important early stages in in hepatitis B virus disease.
Objectives: In order to investigate ARA lncRNA production in Hepatitis B patients, analyze its clinical importance, and examine the possible value as a predictive biomarker, Amplification of Adriamycin Resistance Associated Lnc-RNA and Glyceraldehyde 3-phosphate dehydrogenase (reference gene) was done by two steps reverase- transcriptase polymerase chain reaction ,No significant difference P = 0.566 was observed in the Adriamycin Resistance Associated lncRNA serum levels between chronic hepatitis B virus patient and control ,In the patients group with chronic HBV )infection, the expression of Adriamycin Resistance Associated lncRNAs was elevated to the 2 fold.
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| ISSN: | 1815-0993 2959-183X |