Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand

Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation.

書目詳細資料

發表在:	Nature Communications
Main Authors:	Xianjun Zhang, Fei Zhao, Yiran Wu, Jun Yang, Gye Won Han, Suwen Zhao, Andrii Ishchenko, Lintao Ye, Xi Lin, Kang Ding, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Cornelius Gati, Garrett Nelson, Mark S. Hunter, Michael A. Hanson, Vadim Cherezov, Raymond C. Stevens, Wenfu Tan, Houchao Tao, Fei Xu
格式:	Article
語言:	英语
出版:	Nature Portfolio 2017-05-01
在線閱讀:	https://doi.org/10.1038/ncomms15383