Evaluation of the Function of the ASFV <i>KP177R</i> Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence
African swine fever virus (ASFV) causes a devastating disease of swine that has caused outbreaks in Central Europe since 2007, spreading into Asia in 2018. ASFV is a large, structurally complex virus with a large dsDNA genome encoding for more than 160 genes, most of them still uncharacterized. p22,...
| Published in: | Viruses |
|---|---|
| Main Authors: | Elizabeth A. Vuono, Elizabeth Ramirez-Medina, Sarah Pruitt, Ayushi Rai, Nallely Espinoza, Lauro Velazquez-Salinas, Douglas P. Gladue, Manuel V. Borca |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/6/986 |
Similar Items
African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge
by: Manuel V. Borca, et al.
Published: (2023-10-01)
by: Manuel V. Borca, et al.
Published: (2023-10-01)
ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
by: Manuel V. Borca, et al.
Published: (2021-04-01)
by: Manuel V. Borca, et al.
Published: (2021-04-01)
Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L
by: Xuan Hanh Tran, et al.
Published: (2022-04-01)
by: Xuan Hanh Tran, et al.
Published: (2022-04-01)
Evaluation of an ASFV RNA Helicase Gene A859L for Virus Replication and Swine Virulence
by: Elizabeth Ramirez-Medina, et al.
Published: (2021-12-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2021-12-01)
ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-08-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-08-01)
Identification of a Continuously Stable and Commercially Available Cell Line for the Identification of Infectious African Swine Fever Virus in Clinical Samples
by: Ayushi Rai, et al.
Published: (2020-07-01)
by: Ayushi Rai, et al.
Published: (2020-07-01)
Evaluation of the Function of ASFV Gene E66L in the Process of Virus Replication and Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-02-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-02-01)
X69R Is a Non-Essential Gene That, When Deleted from African Swine Fever, Does Not Affect Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-08-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-08-01)
ASF Vaccine Candidate ASFV-G-∆I177L Does Not Exhibit Residual Virulence in Long-Term Clinical Studies
by: Manuel V. Borca, et al.
Published: (2023-06-01)
by: Manuel V. Borca, et al.
Published: (2023-06-01)
Evaluation in Swine of a Recombinant Georgia 2010 African Swine Fever Virus Lacking the I8L Gene
by: Elizabeth Vuono, et al.
Published: (2020-12-01)
by: Elizabeth Vuono, et al.
Published: (2020-12-01)
Recombinant Vaccine Strain ASFV-G-Δ9GL/ΔUK Produced in the IPKM Cell Line Is Genetically Stable and Efficacious in Inducing Protection in Pigs Challenged with the Virulent African Swine Fever Virus Field Isolate Georgia 2010
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-04-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-04-01)
Evaluation of Cross-Protection of African Swine Fever Vaccine ASFV-G-ΔI177L Between ASFV Biotypes
by: Manuel V. Borca, et al.
Published: (2025-08-01)
by: Manuel V. Borca, et al.
Published: (2025-08-01)
The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine
by: Elizabeth. Ramirez-Medina, et al.
Published: (2020-06-01)
by: Elizabeth. Ramirez-Medina, et al.
Published: (2020-06-01)
Deletion of the ASFV dUTPase Gene <i>E165R</i> from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
by: Elizabeth A. Vuono, et al.
Published: (2022-06-01)
by: Elizabeth A. Vuono, et al.
Published: (2022-06-01)
Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-10-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2020-10-01)
Deletion of the <i>H240R</i> Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-06-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-06-01)
Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-05-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-05-01)
Lyophilization of ASFV vaccine candidate ASFV-G-ΔI177L offers long term stability
by: Nallely Espinoza, et al.
Published: (2024-12-01)
by: Nallely Espinoza, et al.
Published: (2024-12-01)
Evaluation of the Deletion of the African Swine Fever Virus Gene <i>O174L</i> from the Genome of the Georgia Isolate
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-10-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2023-10-01)
Deletion of CD2-Like (CD2v) and C-Type Lectin-Like (EP153R) Genes from African Swine Fever Virus Georgia-∆9GL Abrogates Its Effectiveness as an Experimental Vaccine
by: Douglas P. Gladue, et al.
Published: (2020-10-01)
by: Douglas P. Gladue, et al.
Published: (2020-10-01)
Experimental Infection of Domestic Pigs with an African Swine Fever Virus Field Strain Isolated in 2021 from the Dominican Republic
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-05-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-05-01)
Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
by: Elizabeth A. Vuono, et al.
Published: (2022-07-01)
by: Elizabeth A. Vuono, et al.
Published: (2022-07-01)
Deletion of an African Swine Fever Virus ATP-Dependent RNA Helicase <i>QP509L</i> from the Highly Virulent Georgia 2010 Strain Does Not Affect Replication or Virulence
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-11-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-11-01)
The Presence of Virus Neutralizing Antibodies Is Highly Associated with Protection against Virulent Challenge in Domestic Pigs Immunized with ASFV live Attenuated Vaccine Candidates
by: Ediane B. Silva, et al.
Published: (2022-11-01)
by: Ediane B. Silva, et al.
Published: (2022-11-01)
Deletion of the EP402R Gene from the Genome of African Swine Fever Vaccine Strain ASFV-G-∆I177L Provides the Potential Capability of Differentiating between Infected and Vaccinated Animals
by: Manuel V. Borca, et al.
Published: (2024-02-01)
by: Manuel V. Borca, et al.
Published: (2024-02-01)
Assessment of the Effect of Deleting the African Swine Fever Virus Gene <i>R298L</i> on Virus Replication and Virulence of the Georgia2010 Isolate
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-12-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-12-01)
Evaluation of the Deletion of African Swine Fever Virus E111R Gene from the Georgia Isolate in Virus Replication and Virulence in Domestic Pigs
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-09-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2024-09-01)
Deletion of the African Swine Fever Virus Gen <i>I196L</i> in the Georgia2010 Isolate Genome Does Not Affect Virus Replication or Virulence in Domestic Pigs
by: Elizabeth Ramirez-Medina, et al.
Published: (2025-04-01)
by: Elizabeth Ramirez-Medina, et al.
Published: (2025-04-01)
Antiviral Activity of Plant‐Based Additives Against African Swine Fever Virus (ASFV) in Feed Ingredients
by: Thi Ngoc Ha Lai, et al.
Published: (2024-11-01)
by: Thi Ngoc Ha Lai, et al.
Published: (2024-11-01)
Genotype II Live-Attenuated ASFV Vaccine Strains Unable to Completely Protect Pigs against the Emerging Recombinant ASFV Genotype I/II Strain in Vietnam
by: Nguyen Van Diep, et al.
Published: (2024-09-01)
by: Nguyen Van Diep, et al.
Published: (2024-09-01)
Deletion of the CD2 Gene in the Virulent ASFV Congo Strain Affects Viremia in Domestic Swine, but Not the Virulence
by: Andrey Koltsov, et al.
Published: (2023-06-01)
by: Andrey Koltsov, et al.
Published: (2023-06-01)
Is African Swine Fever Driven by Flying Hematophagous Insects?
by: Marek Walczak, et al.
Published: (2025-06-01)
by: Marek Walczak, et al.
Published: (2025-06-01)
Non-Invasive Sampling in the Aspect of African Swine Fever Detection—A Risk to Accurate Diagnosis
by: Marek Walczak, et al.
Published: (2022-08-01)
by: Marek Walczak, et al.
Published: (2022-08-01)
Recombinant ASF Live Attenuated Virus Strains as Experimental Vaccine Candidates
by: Douglas P. Gladue, et al.
Published: (2022-04-01)
by: Douglas P. Gladue, et al.
Published: (2022-04-01)
African Swine Fever Virus Protein–Protein Interaction Prediction
by: Jacob A. Fenster, et al.
Published: (2024-07-01)
by: Jacob A. Fenster, et al.
Published: (2024-07-01)
KP177R-based visual assay integrating RPA and CRISPR/Cas12a for the detection of African swine fever virus
by: Haorui Luan, et al.
Published: (2024-04-01)
by: Haorui Luan, et al.
Published: (2024-04-01)
African Swine Fever Vaccine Candidate ASFV-G-ΔI177L/ΔLVR Protects Against Homologous Virulent Challenge and Exhibits Long-Term Maintenance of Antibodies
by: Sun A Choi, et al.
Published: (2025-02-01)
by: Sun A Choi, et al.
Published: (2025-02-01)
Experimental Infection of Domestic Pigs with African Swine Fever Virus Isolated in 2019 in Mongolia
by: Chester D. McDowell, et al.
Published: (2022-12-01)
by: Chester D. McDowell, et al.
Published: (2022-12-01)
Growth Kinetics and Protective Efficacy of Attenuated ASFV Strain Congo with Deletion of the EP402 Gene
by: Galina Koltsova, et al.
Published: (2021-06-01)
by: Galina Koltsova, et al.
Published: (2021-06-01)
Porcine Circovirus Type 3 (PCV3) in Poland: Prevalence in Wild Boar Population in Connection with African Swine Fever (ASF)
by: Maciej Piotr Frant, et al.
Published: (2024-05-01)
by: Maciej Piotr Frant, et al.
Published: (2024-05-01)
Similar Items
-
African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge
by: Manuel V. Borca, et al.
Published: (2023-10-01) -
ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
by: Manuel V. Borca, et al.
Published: (2021-04-01) -
Evaluation of the Safety Profile of the ASFV Vaccine Candidate ASFV-G-ΔI177L
by: Xuan Hanh Tran, et al.
Published: (2022-04-01) -
Evaluation of an ASFV RNA Helicase Gene A859L for Virus Replication and Swine Virulence
by: Elizabeth Ramirez-Medina, et al.
Published: (2021-12-01) -
ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine
by: Elizabeth Ramirez-Medina, et al.
Published: (2022-08-01)
